Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Peter D, Katsikis"'
Autor:
Elham Aida Farshadi, Wenya Wang, Farzana Mohammad, Elise van der Oost, Michail Doukas, Casper H. J. van Eijck, Harmen J. G. van de Werken, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) presents challenges in detecting somatic mutations due to its complex cellular composition. This study investigated the utility of patient-derived organoids (PDOs) to overcome these obstacles and enhan
Externí odkaz:
https://doaj.org/article/77ac9a8ef4ef4a1b84739b3ddce172bb
Autor:
Manzhi Zhao, Ling Li, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Floris Dammeijer, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Joachim G. Aerts, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cytotoxic CD8 + T cell (CTL) exhaustion is driven by chronic antigen stimulation. Reversing CTL exhaustion with immune checkpoint blockade (ICB) has provided clinical benefits in different types of cancer. We, therefore, investigated whether
Externí odkaz:
https://doaj.org/article/894d1a0cf952487080d6943e463aba2e
Autor:
Marie de Bakker, Teun B. Petersen, K. Martijn Akkerhuis, Magdalena Harakalova, Victor A. Umans, Tjeerd Germans, Kadir Caliskan, Peter D. Katsikis, Peter J. van der Spek, Navin Suthahar, Rudolf A. de Boer, Dimitris Rizopoulos, Folkert W. Asselbergs, Eric Boersma, Isabella Kardys
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Studies focusing on sex differences in circulating proteins in patients with heart failure with reduced ejection fraction (HFrEF) are scarce. Insight into sex-specific cardiovascular protein profiles and their associations with th
Externí odkaz:
https://doaj.org/article/7452d03e3e184ddc9f2d6d439dc0745f
Autor:
Eveline E. Vietsch, Diba Latifi, Maaike Verheij, Elise W.A. van der Oost, Roeland F. de Wilde, Roel Haen, Anne Loes van den Boom, Bas Groot Koerkamp, Pascal G. Doornebosch, Victorien M.T. van Verschuer, Ariadne H.A.G. Ooms, Farzana Mohammad, Marcella Willemsen, Joachim G.J.V. Aerts, Ricki T. Krog, Noel F.C.C. de Miranda, Thierry P.P. van den Bosch, Yvonne M. Mueller, Peter D. Katsikis, Casper H.J. van Eijck
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid tumors and is resistant to immunotherapy. B cells play an essential role in PDAC progression and immune responses, both locally and systemically. Moreover, increasing evidence
Externí odkaz:
https://doaj.org/article/76e52e62c5914a719b469a7a5bbebb64
Autor:
Ling Li, Manzhi Zhao, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Rudi W. Hendriks, Yvonne M. Mueller, Peter D. Katsikis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptiona
Externí odkaz:
https://doaj.org/article/3847fcbb75c24886b8cbbde00a41f92f
Autor:
Teun B. Petersen, Marie de Bakker, Folkert W. Asselbergs, Magdalena Harakalova, K. Martijn Akkerhuis, Jasper J. Brugts, Jan van Ramshorst, R. Thomas Lumbers, Rachel M. Ostroff, Peter D. Katsikis, Peter J. van der Spek, Victor A. Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104655- (2023)
Summary: Background: HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic biological mechanis
Externí odkaz:
https://doaj.org/article/f7d15c4f779b430a93c911178ae4dfdd
Autor:
Georg Petkau, Twm J. Mitchell, Krishnendu Chakraborty, Sarah E. Bell, Vanessa D´Angeli, Louise Matheson, David J. Turner, Alexander Saveliev, Ozge Gizlenci, Fiamma Salerno, Peter D. Katsikis, Martin Turner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA binding proteins (RBP) have a function in T cell activation and differentiation. Here the authors show that in the absence of two RBPs, ZFP36 and ZFP36L1, T cells acquire more rapidly superior effector capabilities, showing a limiting function fo
Externí odkaz:
https://doaj.org/article/c032f41db1e44009b03c5865b008dfa8
Autor:
Yvonne M. Mueller, Thijs J. Schrama, Rik Ruijten, Marco W. J. Schreurs, Dwin G. B. Grashof, Harmen J. G. van de Werken, Giovanna Jona Lasinio, Daniel Álvarez-Sierra, Caoimhe H. Kiernan, Melisa D. Castro Eiro, Marjan van Meurs, Inge Brouwers-Haspels, Manzhi Zhao, Ling Li, Harm de Wit, Christos A. Ouzounis, Merel E. P. Wilmsen, Tessa M. Alofs, Danique A. Laport, Tamara van Wees, Geoffrey Kraker, Maria C. Jaimes, Sebastiaan Van Bockstael, Manuel Hernández-González, Casper Rokx, Bart J. A. Rijnders, Ricardo Pujol-Borrell, Peter D. Katsikis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Developing predictive methods to identify patients with high risk of severe COVID-19 disease is of crucial importance. Authors show here that by measuring anti-SARS-CoV-2 antibody and cytokine levels at the time of hospital admission and integrating
Externí odkaz:
https://doaj.org/article/8868b5c6ee1046f79b63a7f738da79df
Autor:
Sylvia Kamphuis, Cornelia G van Helden-Meeuwsen, Marjan A Versnel, Anton W Langerak, Mohamed Javad Wahadat, Marleen Verkaaik, Sander J van Tilburg, Yvonne M Mueller, Harm de Wit, Marike J Gruijters, Amani Mubarak, Peter D Katsikis
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss 1 (2023)
Objective To combine targeted transcriptomic and proteomic data in an unsupervised hierarchical clustering method to stratify patients with childhood-onset SLE (cSLE) into similar biological phenotypes, and study the immunological cellular landscape
Externí odkaz:
https://doaj.org/article/2d3bcbf14b7045219b7b1e461c9d0968
Autor:
Kathryn S Hensley, Marlou J Jongkees, Daryl Geers, Corine H GeurtsvanKessel, Yvonne M Mueller, Virgil A S H Dalm, Grigorios Papageorgiou, Hanka Steggink, Alicja Gorska, Susanne Bogers, Jan G den Hollander, Wouter F W Bierman, Luc B S Gelinck, Emile F Schippers, Heidi S M Ammerlaan, Marc van der Valk, Marit G A van Vonderen, Corine E Delsing, Elisabeth H Gisolf, Anke H W Bruns, Fanny N Lauw, Marvin A H Berrevoets, Kim C E Sigaloff, Robert Soetekouw, Judith Branger, Quirijn de Mast, Adriana J J Lammers, Selwyn H Lowe, Rory D de Vries, Peter D Katsikis, Bart J A Rijnders, Kees Brinkman, Anna H E Roukens, Casper Rokx
Publikováno v:
PLoS Medicine, Vol 19, Iss 10, p e1003979 (2022)
BackgroundVaccines can be less immunogenic in people living with HIV (PLWH), but for SARS-CoV-2 vaccinations this is unknown. In this study we set out to investigate, for the vaccines currently approved in the Netherlands, the immunogenicity and reac
Externí odkaz:
https://doaj.org/article/9ad594b98b274203b73f9a4dbe6a6859