Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Peter Cresswell"'
Autor:
Gunjan Arora, Xiaotian Tang, Yingjun Cui, Jing Yang, Yu-Min Chuang, Jayadev Joshi, Andaleeb Sajid, Yuemei Dong, Peter Cresswell, George Dimopoulos, Erol Fikrig
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Gene-edited mosquitoes lacking a gamma-interferon-inducible lysosomal thiol reductase-like protein, namely (mosGILT null ) have lower Plasmodium infection, which is linked to impaired ovarian development and immune activation. The transcript
Externí odkaz:
https://doaj.org/article/66619ebb9ffb456d89af788ff68b0e1a
Autor:
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide
Externí odkaz:
https://doaj.org/article/c0903e0c423a49729d8d0a758d83bc5c
Autor:
Joanna B Pawlak, Jack Chun-Chieh Hsu, Hongjie Xia, Patrick Han, Hee-Won Suh, Tyler L Grove, Juliet Morrison, Pei-Yong Shi, Peter Cresswell, Maudry Laurent-Rolle
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011286 (2023)
Flaviviruses continue to emerge as global health threats. There are currently no Food and Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore, there is a pressing need to identify host and viral factors that c
Externí odkaz:
https://doaj.org/article/4b0c2f150fa74a3386313ece1cbb0c9c
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101654- (2022)
Summary: Translational regulation is a fundamental step in gene expression with critical roles in biological processes within a cell. Here, we describe a protocol to assess translation activity in mammalian cells by incorporation of O-propargyl-purom
Externí odkaz:
https://doaj.org/article/f19999c1b7c445e0aca9c0f1df622408
Autor:
Young-Jun Jeon, Taewan Kim, Dongju Park, Gerard J. Nuovo, Siyeon Rhee, Pooja Joshi, Bum-Kyu Lee, Johan Jeong, Sung-suk Suh, Jeff E. Grotzke, Sung-Hak Kim, Jieun Song, Hosung Sim, Yonghwan Kim, Yong Peng, Youngtae Jeong, Michela Garofalo, Nicola Zanesi, Jonghwan Kim, Guang Liang, Ichiro Nakano, Peter Cresswell, Patrick Nana-Sinkam, Ri Cui, Carlo M. Croce
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
TUSC3 resides on chromosome 8p which is frequently deleted in advanced stage tumors. Here, the authors show that TUSC3 loss mediated by miR-224/-520c promotes NSCLC metastasis where it enhances ATF-6α-dependent UPR and HRD-1 dependent ERAD, which in
Externí odkaz:
https://doaj.org/article/20aea16a00a84e518d6ba422033dbee0
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The mechanism of protein dislocation into the cytosol during antigen cross-presentation is poorly understood. Here the authors engineer a dislocation reporter fusing a glycosylated luciferase variant to the Fc region of IgG1, and find that dislocatio
Externí odkaz:
https://doaj.org/article/c22ebab140ef4bcd9fed474379da587d
Autor:
Tyler R. Schleicher, Jing Yang, Marianna Freudzon, Alison Rembisz, Samuel Craft, Madeleine Hamilton, Morven Graham, Godfree Mlambo, Abhai K. Tripathi, Yue Li, Peter Cresswell, Photini Sinnis, George Dimopoulos, Erol Fikrig
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell trave
Externí odkaz:
https://doaj.org/article/6f1de94305704e90b23021c6aaa9d413
Autor:
Jia Shee Hee, Peter Cresswell
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172236 (2017)
Viperin is an antiviral protein that is upregulated by interferons and by ligands for a variety of innate immune receptors. It possesses diverse capabilities and functions in an array of viral infections. Studies have shown that it appears to be part
Externí odkaz:
https://doaj.org/article/c386d37fda604a94bede69db0819616d
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51343 (2013)
Gamma-interferon-inducible lysosomal thiol reductase (GILT) is known to reduce disulfide bonds present in proteins internalized by antigen presenting cells, facilitating optimal processing and presentation of peptides on Major Histocompatibility Comp
Externí odkaz:
https://doaj.org/article/3cfdb91a197a4ca4b7c53a12e7d967c2
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76801 (2013)
We have investigated the effect of different maturation stimuli on the ability of mature dendritic cells (DCs) to cross-present newly acquired particulate antigens. Cross-presentation was impaired in DCs matured by treatment with TNF-α, CpG and LPS,
Externí odkaz:
https://doaj.org/article/225a398c28904abebf7e34cc4a981ea9