Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Peter Chovanec"'
Autor:
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood. Here the authors generate a high-resolution atlas of gene regulatory interactions, chromat
Externí odkaz:
https://doaj.org/article/7b14988f9bbd452bb5b113c07a446d36
Autor:
Hashem Koohy, Daniel J. Bolland, Louise S. Matheson, Stefan Schoenfelder, Claudia Stellato, Andrew Dimond, Csilla Várnai, Peter Chovanec, Tamara Chessa, Jeremy Denizot, Raquel Manzano Garcia, Steven W. Wingett, Paula Freire-Pritchett, Takashi Nagano, Phillip Hawkins, Len Stephens, Sarah Elderkin, Mikhail Spivakov, Peter Fraser, Anne E. Corcoran, Patrick D. Varga-Weisz
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-24 (2018)
Abstract Background Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell development, we profiled gene expression and chromatin f
Externí odkaz:
https://doaj.org/article/6176506a0b014dd1a2e2a5beb2a2e029
Autor:
Daniel J. Bolland, Hashem Koohy, Andrew L. Wood, Louise S. Matheson, Felix Krueger, Michael J.T. Stubbington, Amanda Baizan-Edge, Peter Chovanec, Bryony A. Stubbs, Kristina Tabbada, Simon R. Andrews, Mikhail Spivakov, Anne E. Corcoran
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2475-2487 (2016)
Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene usage. We have developed VDJ
Externí odkaz:
https://doaj.org/article/2754b12283b14484b5441338b9c3ac7a
Autor:
Louise S. Matheson, Daniel J. Bolland, Peter Chovanec, Felix Krueger, Simon Andrews, Hashem Koohy, Anne E. Corcoran
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We recently developed the DNA
Externí odkaz:
https://doaj.org/article/308388b4b3d8483f8570a4664004ecad
Autor:
Carlo V. Bruschi, Lluis Montoliu, Brian Mcguinness, Dmitri Nikitin, Mike Romanos, Philip Hayes, Lorraine Thompson, Anne E. Corcoran, Colette Johnston, Michele Writer, Krešimir Gjuračić, Peter Chovanec, Yun Sanders, Yumin Teng, Joyce Young, Yanjing Zhang, Louise S. Matheson, Bryan Edwards, Valentina Tosato, Beatrice Rossi, Thomas Sandal, Carolyn Edwards, Debora Pinto, Mila Roode, Almudena Fernández
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
© 2019 The Authors.
We describe the ‘Crescendo Mouse’, a human VH transgenic platform combining an engineered heavy chain locus with diverse human heavy chain V, D and J genes, a modified mouse Cγ1 gene and complete 3’ regulatory region,
We describe the ‘Crescendo Mouse’, a human VH transgenic platform combining an engineered heavy chain locus with diverse human heavy chain V, D and J genes, a modified mouse Cγ1 gene and complete 3’ regulatory region,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad59b3384db0f058b272b55144c42a8d
https://doi.org/10.1016/j.nbt.2019.10.003
https://doi.org/10.1016/j.nbt.2019.10.003
Autor:
Stefan Schoenfelder, Csilla Várnai, Peter J. Rugg-Gunn, Anne E. Corcoran, Amanda J. Collier, Christel Krueger, Peter Chovanec, Claudia I. Semprich
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The transition from naive to primed pluripotency is accompanied by an extensive reorganisation of transcriptional and epigenetic programmes. However, the role of transcriptional enhancers and three-dimensional chromatin organisation in coordinating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed9a3a7fcbed0822295ba9e21a818ef
https://doi.org/10.1038/s41467-021-22201-4
https://doi.org/10.1038/s41467-021-22201-4
Autor:
Peter Chovanec, Yi Yin
Publikováno v:
Methods in Enzymology ISBN: 9780323907330
Methods Enzymol
Methods Enzymol
Mitotic crossovers have the potential to cause large-scale genome rearrangements. Here, we describe high-throughput, single-cell, whole-genome sequencing methods for mapping crossovers genome-wide at scale. The methods are generalizable to various eu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cde7c497816989073743028dca1df20
https://doi.org/10.1016/bs.mie.2021.08.017
https://doi.org/10.1016/bs.mie.2021.08.017
Autor:
Stefan Schoenfelder, Csilla Várnai, Amanda J. Collier, Peter Chovanec, Christel Krueger, Anne E. Corcoran, Peter J. Rugg-Gunn
SUMMARYA complex and poorly understood interplay between 3D genome organisation, transcription factors and chromatin state underpins cell identity. To gain a systems-level understanding of this interplay, we generated a high-resolution atlas of annot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a4564dcfaafb7e96fc8295d6f2924e
Autor:
Sofia A. Quinodoz, Prashant Bhat, Peter Chovanec, Joanna W. Jachowicz, Noah Ollikainen, Elizabeth Detmar, Elizabeth Soehalim, Mitchell Guttman
Publikováno v:
Nature protocols. 17(1)
A fundamental question in gene regulation is how cell-type-specific gene expression is influenced by the packaging of DNA within the nucleus of each cell. We recently developed Split-Pool Recognition of Interactions by Tag Extension (SPRITE), which e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4234e671508bc168b432d4c8fc1ddd29
https://pubmed.ncbi.nlm.nih.gov/35013617
https://pubmed.ncbi.nlm.nih.gov/35013617
Publikováno v:
IEEE Transactions on Industrial Electronics. 65:543-552
Although there are many reasons why medium voltage (MV) overhead lines with covered conductors (CCs) are used instead of aluminum-conductor steel-reinforced cables, the operation of CCs takes into account a difficult detection of faults, e.g., the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac0ca9ceba70690dac4ab6607908f81
https://doi.org/10.1109/tie.2017.2716861
https://doi.org/10.1109/tie.2017.2716861