Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peter Cage"'
Autor:
Phillip A. Abbott, Roger Bonnert, Peter Cage, Steve Hill, Mark Furber, Moya Caffrey, David Donald, Andrew Cooke, Jane Withnall
Publikováno v:
Tetrahedron. 58:3185-3198
General methods are descibed for the synthesis of mesoionic derivatives of [1,2,3]triazolo[1,5-a]quinoline, [1,2,3]triazolo[1,5-a]quinazoline, [1,2,3]triazolo[1,5-a]quinoxaline and [1,2,3]triazolo[5,1-c]benzotriazine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::676797cff63a60530329ac62f53e1a79
https://doi.org/10.1016/s0040-4020(02)00269-7
https://doi.org/10.1016/s0040-4020(02)00269-7
Autor:
Rupert P. Austin, Karl Edman, Hitesh J. Sanganee, Raj Beri, Peter Cage, Christopher A. Luckhurst, Jason Breed, Ian Millichip, Victor I. C. Oreffo, Bob Thong, Antonio Mete, Kamaldeep K. Chohan, Steve T. Harper, Alan V. Wallace, Elizabeth Kinchin, Lisa Wissler, Judit E. Debreczeni, Andrew Mather, Anna-Karin Tidén, Mark Furber, Rhonan Ford, Ray Hutchinson, Simon Barber, Philip Gardiner, Linda Stein
Publikováno v:
Journal of medicinal chemistry. 57(6)
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda9c1a5aff14abe1c0e7c7ba7f3ddb3
https://pubmed.ncbi.nlm.nih.gov/24592859
https://pubmed.ncbi.nlm.nih.gov/24592859
Autor:
Steve Hill, David Donald, Moya Caffrey, Mark Furber, Phillip A. Abbott, Roger Bonnert, Jane Withnall, Andrew Cooke, Peter Cage
Publikováno v:
ChemInform. 33
General methods are descibed for the synthesis of mesoionic derivatives of [1,2,3]triazolo[1,5-a]quinoline, [1,2,3]triazolo[1,5-a]quinazoline, [1,2,3]triazolo[1,5-a]quinoxaline and [1,2,3]triazolo[5,1-c]benzotriazine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92d6766518f5c54d0bb07f1db8c4c842
https://doi.org/10.1002/chin.200237134
https://doi.org/10.1002/chin.200237134
Autor:
Mark I Christie, Roger Bonnert, Mark Ebden, Peter Cage, Iain Walters, Fraser Hunt, Shirley Lewis, Caroline Austin, Caroline Grahames, David J. Nicholls, Rupert P. Austin, Robert Jewell, Steven Hill, Iain J. Martin, David J. Robinson, Stuart Gardiner
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
The CXCR2 SAR of a series of bicyclic antagonists such as the 2-aminothiazolo[4,5-d]pyrimidine 3b was investigated by systematic variation of the fused pyrimidine-based heterocyclic cores. Replacement of the aminothiazole ring with a 2-thiazolone alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac2ff5b3bea99bb7e120f06b772d80c
https://pubmed.ncbi.nlm.nih.gov/18240390
https://pubmed.ncbi.nlm.nih.gov/18240390
Autor:
Clare Dixon, David J. Robinson, Mark I Christie, Steven Hill, Jadeen Christie, Ian Martin, Rupert P. Austin, Robert Jewell, Paul Willis, Peter Cage, Caroline Austin, Fraser Hunt, Roger Bonnert
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(10)
As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22c6b4e0fd918761df7048c4a39a493
https://pubmed.ncbi.nlm.nih.gov/17382543
https://pubmed.ncbi.nlm.nih.gov/17382543
Autor:
Rupert P. Austin, Iain G. Dougall, Roger Bonnert, Garry Pairaudeau, Patrick Barton, Andrew M. Davis, Brown Roger Charles, David Cheshire, Peter Cage, Alan Young, Francis Ince
Publikováno v:
Journal of medicinal chemistry. 46(15)
This paper describes the development of a QSAR model for the rational control of functional duration of topical long-acting dual D(2)-receptor/beta(2)-adrenoceptor agonists for the treatment of chronic obstructive pulmonary disease. A QSAR model high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45284fdc49d973a621a41f6b78f732c5
https://pubmed.ncbi.nlm.nih.gov/12852752
https://pubmed.ncbi.nlm.nih.gov/12852752
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 31(6)
The metabolism of 3-([3-(2-Chlorophenyl)-4,5-dihydro-5-thioxo-1H-1,2,4-triazol-1-yl]methyl)benzonitrile (AR-C133611XX) was studied in isolated dog hepatocytes. The major metabolite of AR-C133611XX was characterized by high performance liquid chromato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea04c8b2d7fe1bb09ce4b7b28794a0f
https://pubmed.ncbi.nlm.nih.gov/12756198
https://pubmed.ncbi.nlm.nih.gov/12756198
Publikováno v:
Drug Metabolism and Disposition; June 2003, Vol. 31 Issue: 6 p694-6, 3p