Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Peter C. Stapor"'
Publikováno v:
Current Opinion in Biotechnology. 34:73-81
For eukaryotic cells to function properly, they divide their intracellular space in subcellular compartments, each harboring specific metabolic activities. In recent years, it has become increasingly clear that compartmentalization of metabolic pathw
Publikováno v:
EMBO Molecular Medicine
The endothelium is the orchestral conductor of blood vessel function. Pathological blood vessel formation (a process termed pathological angiogenesis) or the inability of endothelial cells (ECs) to perform their physiological function (a condition kn
Publikováno v:
Microcirculation. 21:345-357
In pathological scenarios, such as tumor growth and diabetic retinopathy, blocking angiogenesis would be beneficial. In others, such as myocardial infarction and hypertension, promoting angiogenesis might be desirable. Due to their putative influence
Autor:
Jermaine Goveia, Ton J. Rabelink, Lena Christin Conradi, Bram Boeckx, Bart Ghesquière, Pallavi Chaturvedi, Joanna Kalucka, Kim R. Kampen, Lucas Treps, Diether Lambrechts, Francesco Bifari, Koen Veys, Guy Eelen, Asrar B. Malik, Johanna Hol, Bert Cruys, Jalees Rehman, Joris Vriens, Tor Espen Stav-Noraas, Sandra Schoors, Luc Schoonjans, Katrien De Bock, Guttorm Haraldsen, Laure Anne Teuwen, Andreas Pircher, Anna Kuchnio, Aleksandra Brajic, Peter Carmeliet, Anna Rita Cantelmo, Peter C. Stapor, Lise Finotto, Mieke Dewerchin, Bernard Thienpont, Ilaria Decimo
Publikováno v:
Cancer Cell, 30(6), 968-985
Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as an anti-cancer treatment. Here, we show that tumor endothelial cells (ECs) have a hyperglycolytic metabolism, shunting intermedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c09a7524dbfa29f31a1da1ac32cffa
https://doi.org/10.1016/j.ccell.2016.10.006
https://doi.org/10.1016/j.ccell.2016.10.006
Publikováno v:
Cardiovascular Engineering and Technology. 2:124-136
Fluid shear stress has been implicated as a regulator of sprouting angiogenesis. However, whether endothelial cells within capillary sprouts in vivo experience physiologically relevant shear stresses remains unclear. The objective of our study is to
Publikováno v:
Cancer & Metabolism
The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to the widel
Publikováno v:
Journal of cell science. 127(Pt 20)
Clinically approved therapies that target angiogenesis in tumors and ocular diseases focus on controlling pro-angiogenic growth factors in order to reduce aberrant microvascular growth. Although research on angiogenesis has revealed key mechanisms th
Autor:
Annalisa Zecchin, Peter C. Stapor, Jermaine Goveia, Francisco Morales Rodriguez, Peter Carmeliet, Stijn Moens
Publikováno v:
Circulation Research
Vessel sprouting relies on the differentiation of endothelial cells (ECs) into a migratory tip cell leading at the forefront, proliferating stalk cells elongating the vessel stalk, and quiescent phalanx cells lining the perfused vessel.1 The tip vers
Publikováno v:
Cytokinegrowth factor reviews. 25(4)
Vascular endothelial growth factor (VEGF) is a key growth factor driving angiogenesis (i.e. the formation of new blood vessels) in health and disease. Pharmacological blockade of VEGF signaling to inhibit tumor angiogenesis is clinically approved but
Publikováno v:
PanVascular Medicine ISBN: 9783642373930
PanVascular Medicine ISBN: 9783642370779
PanVascular Medicine ISBN: 9783642370779
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6181c8099de3ab42a7c404f41a6f3c
https://doi.org/10.1007/978-3-642-37393-0_10-1
https://doi.org/10.1007/978-3-642-37393-0_10-1