Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Peter C. Ruben"'
Autor:
David Hollingworth, Frances Thomas, Dana A. Page, Mohamed A. Fouda, Raquel Lopez-Rios De Castro, Altin Sula, Vitaliy B. Mykhaylyk, Geoff Kelly, Martin B. Ulmschneider, Peter C. Ruben, B. A. Wallace
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (INaL). INaL results from in
Externí odkaz:
https://doaj.org/article/eeabfb2a411349818eb73589abebceae
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ab20e6e326e243daa6d72ef6614f601c
Autor:
Mohammad-Reza Ghovanloo, Sulayman D. Dib-Hajj, Samuel J. Goodchild, Peter C. Ruben, Stephen G. Waxman
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Phytocannabinoids, found in the plant, Cannabis sativa, are an important class of natural compounds with physiological effects. These compounds can be generally divided into two classes: psychoactive and non-psychoactive. Those which do not impart ps
Externí odkaz:
https://doaj.org/article/baedbfaa8dce47ffb3e44ca8a92a4318
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Most therapeutics targeting cardiac voltage-gated sodium channels (Nav1.5) attenuate the sodium current (INa) conducted through the pore of the protein. Whereas these drugs may be beneficial for disease states associated with gain-of-func
Externí odkaz:
https://doaj.org/article/e9e74ccd0a01473e89e7ac575120ecc8
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
Gramicidin is a monomeric protein that is thought to non-selectively conduct cationic currents and water. Linear gramicidin is considered an antibiotic. This function is considered to be mediated by the formation of pores within the lipid membrane, t
Externí odkaz:
https://doaj.org/article/9e58c7e03aee47e588e2f34ea64d4428
Autor:
Laura B. Jones, Colin H. Peters, Richard E. Rosch, Maxine Owers, Elaine Hughes, Deb K. Pal, Peter C. Ruben
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Variants of the SCN1A gene encoding the neuronal voltage-gated sodium channel NaV1.1 cause over 85% of all cases of Dravet syndrome, a severe and often pharmacoresistent epileptic encephalopathy with mostly infantile onset. But with the increased ava
Externí odkaz:
https://doaj.org/article/ec6ce9af36bc4a238ada273bf434f84e
Autor:
Mohamed A. Fouda, Peter C. Ruben
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Cardiovascular anomalies are predisposing factors for diabetes-induced morbidity and mortality. Recently, we showed that high glucose induces changes in the biophysical properties of the cardiac voltage-gated sodium channel (Nav1.5) that
Externí odkaz:
https://doaj.org/article/2313187d27ef46d8b5db39ef4dbbf94a
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundSudden cardiac death (SCD) is an unexpected death that occurs within an hour of the onset of symptoms. Hereditary primary electrical disorders account for up to 1/3 of all SCD cases in younger individuals and include conditions such as cate
Externí odkaz:
https://doaj.org/article/7000404825074161915bb27dbf4c1128
Autor:
Lily Goodyer Sait, Altin Sula, Mohammad-Reza Ghovanloo, David Hollingworth, Peter C Ruben, BA Wallace
Publikováno v:
eLife, Vol 9 (2020)
Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of
Externí odkaz:
https://doaj.org/article/f7ec069f3ef44283b246e6a8cbe1f16d
Publikováno v:
British Journal of Pharmacology. 179:5259-5272
Sepsis, caused by a dysregulated response to infections, can lead to cardiac arrhythmias. However, the mechanisms underlying sepsis-induced inflammation, and how inflammation provokes cardiac arrhythmias, are not well understood. We hypothesized that