Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Peter C. Mcminn"'
Autor:
Peter C. McMinn
Publikováno v:
Journal of Pediatric Infectious Diseases. :017-023
Since its discovery in 1970, enterovirus 71 (EV71) has increasingly been recognized as a cause of epidemics of hand-foot-and-mouth disease (HFMD) associated with severe neurological complications in a proportion of cases. There has been a large incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50bb94f7b0508c71335bf0942fb59178
https://doi.org/10.1055/s-0035-1557069
https://doi.org/10.1055/s-0035-1557069
Autor:
Peter C. McMinn, Sara Sadeghipour
Publikováno v:
Virus Research
Highlights • Here we describe the mouse virulence properties of high replication fidelity 3D polymerase variants of HEV71. • Mouse-adapted HEV71 strains were constructed to compare the virulence of the 3D polymerase variants with that of mouse-ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d71788cef7fd8c8104b7f4360a5260
https://doi.org/10.1016/j.virusres.2013.06.019
https://doi.org/10.1016/j.virusres.2013.06.019
Publikováno v:
Journal of Virology. 87:1759-1769
It has been shown in animal models that ribavirin-resistant poliovirus with a G64S mutation in its 3D polymerase has high replication fidelity coupled with attenuated virulence. Here, we describe the effects of mutagenesis in the human enterovirus 71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7add44d1938eccfb79a54eb436cb4a19
https://doi.org/10.1128/jvi.02139-12
https://doi.org/10.1128/jvi.02139-12
Publikováno v:
Virus Research. 169:72-79
The replication of human enterovirus 71 (HEV71) in cell culture is inhibited by concentrations of guanidine that do not have an observable adverse effect on host cell metabolism. Although the HEV71 non-structural protein 2C is known to play an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1a2db37f149dba744e991a6feec76f
https://doi.org/10.1016/j.virusres.2012.07.005
https://doi.org/10.1016/j.virusres.2012.07.005
Publikováno v:
Virus Research. 167:86-96
Most human enterovirus 71 (HEV71) strains infect only primates and are unable to cause clinically apparent infection in mice. Here we describe a mouse-adapted HEV71 strain that belongs to sub-genogroup B5 with increased virulence in newborn BALB/c mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fd61d1f5c12e8de918d3d572cbcebf
https://doi.org/10.1016/j.virusres.2012.04.009
https://doi.org/10.1016/j.virusres.2012.04.009
Autor:
Peter C. McMinn, Emily J. Bek
Publikováno v:
Current Infectious Disease Reports. 14:397-407
Human enterovirus 71 (HEV71) has emerged as a major cause of viral encephalitis in Southeast Asia, with increased epidemic activity observed since 1997. This is reflected in a large increase in scientific publications relating directly to HEV71. New
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c307d7c24e2f23d942a2a457a1cbd71
https://doi.org/10.1007/s11908-012-0267-3
https://doi.org/10.1007/s11908-012-0267-3
Publikováno v:
Virus Research. 165:151-156
We selected Chinese hamster ovary (CHO) cell-adapted strains of human enterovirus 71 (HEV71) belonging to sub-genogroups B5 (HEV71-B5) and C2 (HEV71-C2) by serial passage in CHO cells at a high multiplicity of infection. During the course of CHO cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22374715eea17ea64c8506dd6642c143
https://doi.org/10.1016/j.virusres.2012.02.009
https://doi.org/10.1016/j.virusres.2012.02.009
Publikováno v:
Journal of Virology. 86:542-552
Human enterovirus 71 (HEV71) is the causative agent of hand, foot, and mouth disease and associated acute neurological disease. At present, little is known about the genetic determinants of HEV71 neurovirulence. Studies of related enteroviruses have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef24be672e159ccfb088540650bf2002
https://doi.org/10.1128/jvi.00069-11
https://doi.org/10.1128/jvi.00069-11
Autor:
J. Leung, Roy A. Hall, Mario Lobigs, Natalie A. Prow, Robert J. Hurrelbrink, David C. Clark, John S. Mackenzie, Peter C. McMinn, Fiona J. May, Alexander A. Khromykh, Daniel J. Westlake, Rebecca M. Biron
Publikováno v:
Journal of General Virology. 92:2286-2296
Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus endemic to Australia and Papua New Guinea. Most strains of MVEV cause potentially fatal cases of encephalitis in humans and horses, and have been shown to be highly neuroinvasive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef94f336d99d9d9c8ef8c703cb0cd1b
https://doi.org/10.1099/vir.0.034793-0
https://doi.org/10.1099/vir.0.034793-0
Autor:
Patchara Phuektes, Fang Cai, Peter C. McMinn, Khairunnisa Mohamed Hussain, Chee Choy Kok, Emily J. Bek, Zhenglun Gao, Qiang Gao
Publikováno v:
Vaccine. 29:4829-4838
Human enterovirus 71 (HEV71) has emerged as a major cause of epidemics of hand, foot and mouth disease associated with severe neurological sequelae in the Asia-Pacific region. In this study, a passive protection mouse model was used to evaluate the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0221381e2bd00b6777f4297cd5eb520
https://doi.org/10.1016/j.vaccine.2011.04.070
https://doi.org/10.1016/j.vaccine.2011.04.070