Výsledky vyhledávání - "Peter C. McDonnell"

Cloning, Expression, and Initial Characterization of a Novel Cytokine-like Gene Family

Publikováno v: Genomics. 80:144-150

We report the identification and characterization of a novel cytokine-like gene family using structure-based methods to search for novel four-helix-bundle cytokines in genomics databases. There are four genes in this family, FAM3A, FAM3B, FAM3C, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8feb22e567278cfc84978801b6a61a
https://doi.org/10.1006/geno.2002.6816

Zobrazit plný text záznamu

Herpesvirus Entry Mediator Ligand (HVEM-L), a Novel Ligand for HVEM/TR2, Stimulates Proliferation of T Cells and Inhibits HT29 Cell Growth

Autor: Peter R. Young, Jeremy A. Harrop, Christopher Eichman, Keith C. Deen, Alemseged Truneh, Carol Silverman, Peter C. McDonnell, Jay Spampanato, Sally D. Lyn, Michael Brigham-Burke, Rocco DiPrinzio, K.B. Tan, Kim Dede, John Emery, Marie Chabot-Fletcher, Preston Hensley, Jayne Minton

Publikováno v: Journal of Biological Chemistry. 273:27548-27556

Herpesvirus entry mediator (HVEM), a member of the tumor necrosis factor (TNF) receptor family, mediates herpesvirus entry into cells during infection. Upon overexpression, HVEM activates NF-kappaB and AP-1 through a TNF receptor-associated factor (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de12b20ee38b627b27c15caf4e258482
https://doi.org/10.1074/jbc.273.42.27548

Zobrazit plný text záznamu

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

Autor: John C. Lee, Peter R. Young, Annalisa T. Hand, Peter C. McDonnell, Rebecca J. Gum, Sanjay Kumar

Publikováno v: Biochemical and Biophysical Research Communications. 235:533-538

A novel homologue of p38 MAP kinase, called SAPK4, has been cloned which shares 61% amino acid identity with p38 and is expressed predominantly in testes, pancreas and small intestine. We also cloned an alternative form of p38beta, termed p38beta2, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3f7de5f54c11a3f9978bf8ee978762
https://doi.org/10.1006/bbrc.1997.6849

Zobrazit plný text záznamu

Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site

Autor: Timothy Francis Gallagher, Seth M. Fisher, Peter C. McDonnell, George P. Livi, George Leslie Seibel, Megan M. McLaughlin, Steven A. Carr, John C. Lee, Shouki Kassis, Sanjay Kumar, Jerry L. Adams, Terence G. Porter, Dean E. McNulty, Peter R. Young, Michael L. Doyle, Michael J. Huddleston

Publikováno v: Journal of Biological Chemistry. 272:12116-12121

The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production in vivo has been determined. Using Edman sequencing, 125I-SB2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d640422c25ef6c1dfe2422f9bfa5bf6
https://doi.org/10.1074/jbc.272.18.12116

Zobrazit plný text záznamu

Activation of the HIV-1 Long Terminal Repeat by Cytokines and Environmental Stress Requires an Active CSBP/p38 MAP Kinase

Autor: Christine Debouck, Peter C. McDonnell, Sanjay Kumar, John C. Lee, Peter Young, Michael J. Orsini

Publikováno v: Journal of Biological Chemistry. 271:30864-30869

The human immunodeficiency virus, type 1 (HIV-1) promoter is known to be activated by proinflammatory cytokines and UV light. These stimuli also activate various members of the mitogen-activated protein kinase family, including JNK/SAPK and CSBP/p38.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe91edec32728f1962474497b97fb72e
https://doi.org/10.1074/jbc.271.48.30864

Zobrazit plný text záznamu

Human Mitogen-activated Protein Kinase CSBP1, but Not CSBP2, Complements a hog1 Deletion in Yeast

Autor: Peter Young, Sanjay Kumar, George P. Livi, Peter C. McDonnell, John C. Lee, Megan M. McLaughlin

Publikováno v: Journal of Biological Chemistry. 270:29043-29046

CSBP1 and CSBP2 are human homologues of the Saccharomyces cerevisiae Hog1 mitogen-activated protein kinase which is required for growth in high osmolarity media. Expression of CSBP1, but not CSBP2, complemented a hog1 delta phenotype. A CSBP2 mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815b9eff7a12410e3a610a7a75d59a5c
https://doi.org/10.1074/jbc.270.49.29043

Zobrazit plný text záznamu

Binding Interactions of Human Interleukin 5 with Its Receptor α Subunit

Publikováno v: Journal of Biological Chemistry. 270:9459-9471

Human interleukin 5 (hIL5) and soluble forms of its receptor α subunit were expressed in Drosophila cells and purified to homogeneity, allowing a detailed structural and functional analysis. B cell proliferation confirmed that the hIL5 was biologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0afdc73275b33eae60c412e03f39b3
https://doi.org/10.1074/jbc.270.16.9459

Zobrazit plný text záznamu

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Autor: J. R. Heys, S. W. Landvatter, Joseph C. Lee, James E. Strickler, George P. Livi, Jerry L. Adams, Dean E. McNulty, Jeffrey T. Laydon, Sanjay Kumar, John R. White, I. R. Siemens, Timothy Gallagher, M. J. Blumenthal, David W. Green, Peter Young, Peter C. McDonnell, Megan M. McLaughlin, Seth M. Fisher

Publikováno v: Nature. 372:739-746

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24d7b582bf7042b4595ca6a9251e1cd
https://doi.org/10.1038/372739a0

Zobrazit plný text záznamu

Identification and initial characterization of four novel members of the interleukin-1 family

Autor: Grace I. Wells, M. N. Tzimas, Peter R. Young, Elizabeth A. Capper, Michael L. Doyle, Ruth Tal-Singer, Peter C. McDonnell, Sanjay Kumar, Lauren A. Tierney, Ruth Lehr, Don E. Griswold

Publikováno v: The Journal of biological chemistry. 275(14)

Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted factors that share a common beta-barrel structure and act on target cells by binding to cell surface receptors with immunoglobulin-like folds in their extracell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae0219e8858c53e16ace7197aaf3d3c
https://pubmed.ncbi.nlm.nih.gov/10744718

Zobrazit plný text záznamu

Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL

Autor: Rocco DiPrinzio, Ian E. James, R.A. Dodds, Carol Silverman, Appelbaum Edward Robert, Martin Rosenberg, Michael Brigham Burke, Chris Eichman, John Emery, Edward Dul, Peter C. McDonnell, Peter Young, John C. Lee, Sally D. Lyn, Keith Charles Deen

Publikováno v: The Journal of biological chemistry. 273(23)

TRAIL is a tumor necrosis factor-related ligand that induces apoptosis upon binding to its death domain-containing receptors, DR4 and DR5. Two additional TRAIL receptors, TRID/DcR1 and DcR2, lack functional death domains and function as decoy recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2e43d940710ac9601211283cb787ca
https://pubmed.ncbi.nlm.nih.gov/9603945

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání