Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Peter C. J. Schmeits"'
Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models
Autor:
Mirjam M. Schaap, E. van Someren, Peter C. J. Schmeits, Peter J.M. Hendriksen, M. Luijten, Ad A. C. M. Peijnenburg, H. van Loveren, André Boorsma
Publikováno v:
Archives of Toxicology, 12, 89, 2325-2337
Archives of Toxicology, 89(12), 2325-2337
Archives of Toxicology 89 (2015) 12
Archives of Toxicology, 89(12), 2325-2337. Springer
Archives of Toxicology, 89(12), 2325-2337
Archives of Toxicology 89 (2015) 12
Archives of Toxicology, 89(12), 2325-2337. Springer
Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be7ec6d1a47efd3d841c0af6f5ca0a4
https://doi.org/10.1007/s00204-014-1365-9
https://doi.org/10.1007/s00204-014-1365-9
Autor:
Sandra W. M. van Kol, Ad A. C. M. Peijnenburg, Peter C. J. Schmeits, Peter J.M. Hendriksen, Henk Van Loveren
Publikováno v:
Toxicology Research 3 (2014) 4
Toxicology Research, 3(4), 254-265
Toxicology Research, 3(4), 254-265. Royal Society of Chemistry
Toxicology Research, 3(4), 254-265
Toxicology Research, 3(4), 254-265. Royal Society of Chemistry
The main goal of this study was to assess the potential of the mouse thymoma EL-4 cell line in screening for chemical induced immunotoxicity. Therefore, EL-4 cells were exposed to two well-known immunotoxicants, organotin compound tributyltin oxide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b935fd64dbded846906c86bb6ba07bb1
https://doi.org/10.1039/c3tx50100k
https://doi.org/10.1039/c3tx50100k
Autor:
Peter J.M. Hendriksen, Peter C. J. Schmeits, H. van Loveren, Ad A. C. M. Peijnenburg, Jia Shao
Publikováno v:
Molecular Immunotoxicology
Molecular Immunotoxicology. West Sussex: Wiley-VCH Verlag
Molecular Immunotoxicology. West Sussex: Wiley-VCH Verlag
This chapter focuses mainly on the effects of organotin compounds in various human and animal models and describes the research performed to elucidate the immunotoxic mechanism of action of organotin compounds. Both dibutyltin (DBT) and tributyltins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5172d76d0a385f5ac722f1b458e446b0
https://research.wur.nl/en/publications/mode-of-action-of-organotins-in-immune-cells
https://research.wur.nl/en/publications/mode-of-action-of-organotins-in-immune-cells
Autor:
Peter C J, Schmeits, Jia, Shao, Danique A, van der Krieken, Oscar L, Volger, Henk, van Loveren, Ad A C M, Peijnenburg, Peter J M, Hendriksen
Publikováno v:
Journal of applied toxicology : JAT. 35(7)
Previously, we identified 25 classifier genes that were able to assess immunotoxicity using human Jurkat T cells. The present study aimed to validate these classifiers. For that purpose, Jurkat cells were exposed for 6 h to subcytotoxic doses of nine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::926d28610fdc319aeb14b485cd916ef2
https://pubmed.ncbi.nlm.nih.gov/25424538
https://pubmed.ncbi.nlm.nih.gov/25424538
Autor:
Madhumohan R. Katika, Peter C. J. Schmeits, Peter J.M. Hendriksen, Henk Van Loveren, Ad A. C. M. Peijnenburg
Publikováno v:
Toxicology Letters, 224(3), 395-406. Elsevier Ireland Ltd
Toxicology Letters 224 (2014) 3
Toxicology Letters, 224(3), 395-406
Toxicology Letters 224 (2014) 3
Toxicology Letters, 224(3), 395-406
Previously, we studied the effects of deoxynivalenol (DON) and tributyltin oxide (TBTO) on whole genome mRNA expression profiles of human T lymphocyte Jurkat cells. These studies indicated that DON induces ribotoxic stress and both DON and TBTO induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4360ac24ae9bc8de6c70fa612a5e537c
https://cris.maastrichtuniversity.nl/en/publications/dfec1374-73eb-4de9-b517-7b5304e4ea2c
https://cris.maastrichtuniversity.nl/en/publications/dfec1374-73eb-4de9-b517-7b5304e4ea2c
Autor:
Jeroen L. A. Pennings, Tessa E. Pronk, E. van Someren, Rob Stierum, Dinant Kroese, J. Fostel, Peter C. J. Schmeits, J. Shao
Systems toxicology relies on data integration from a variety of disciplines. These include the toxicological phenotype and in vitro assay data, together with a system-wide response such as transcriptomics data. To facilitate this, databases to captur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6acad4d55bab329b91d6c39090363e05
https://doi.org/10.1016/b978-0-12-397862-2.00023-1
https://doi.org/10.1016/b978-0-12-397862-2.00023-1
Autor:
Ella T. Zandvliet, Oscar L. Volger, Ad A. C. M. Peijnenburg, Peter C. J. Schmeits, Peter J.M. Hendriksen, Henk Van Loveren
Publikováno v:
Toxicology Letters, 217(1), 1-13
Toxicology Letters, 217(1), 1-13. Elsevier Ireland Ltd
Toxicology Letters 217 (2013) 1
Toxicology Letters, 217(1), 1-13. Elsevier Ireland Ltd
Toxicology Letters 217 (2013) 1
A toxicogenomics approach was applied to assess the usefulness of the mouse cytotoxic T cell line CTLL-2 for in vitro immunotoxicity testing. CTLL-2 cells were exposed for 6 h to two model immunotoxic compounds: (1) the mycotoxin deoxynivalenol (DON,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09d5234256beec502d706d2dc32a4ce
https://research.wur.nl/en/publications/assessment-of-the-usefulness-of-the-murine-cytotoxic-t-cell-line-
https://research.wur.nl/en/publications/assessment-of-the-usefulness-of-the-murine-cytotoxic-t-cell-line-
Autor:
Henk Van Loveren, Oscar L. Volger, Peter C. J. Schmeits, Ad A. C. M. Peijnenburg, Peter J. M. Hendriksen, Madhumohan R. Katika, Jia Shao
Publikováno v:
Toxicological sciences 135 (2013) 2
Toxicological Sciences, 135(2), 328-346. Oxford University Press
Toxicological sciences, 135(2), 328-346
Toxicological Sciences, 135(2), 328-346. Oxford University Press
Toxicological sciences, 135(2), 328-346
Compounds with direct immunotoxic properties, including metals, mycotoxins, agricultural pesticides, and industrial chemicals, form potential human health risks due to exposure through food, drinking water, and the environment. Insights into the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7201a0fde5d2f2df703caea4253b3c
https://research.wur.nl/en/publications/toxicogenomics-based-identification-of-mechanisms-for-direct-immu
https://research.wur.nl/en/publications/toxicogenomics-based-identification-of-mechanisms-for-direct-immu
Autor:
Oscar L. Volger, Peter J.M. Hendriksen, Henk Van Loveren, Peter C. J. Schmeits, Jia Shao, Ad A. C. M. Peijnenburg
Publikováno v:
Toxicology Letters. 221:S31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e6aa300ab88fadb5bc41454493dec6
https://doi.org/10.1016/j.toxlet.2013.06.108
https://doi.org/10.1016/j.toxlet.2013.06.108