Zobrazeno 1 - 10
of 397
pro vyhledávání: '"Peter C. Harris"'
Autor:
Atlas Khan, Ning Shang, Jordan G. Nestor, Chunhua Weng, George Hripcsak, Peter C. Harris, Ali G. Gharavi, Krzysztof Kiryluk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A-associated nephropathy (COL4A-AN) represent the most common forms of
Externí odkaz:
https://doaj.org/article/675519d846a343a897e38aab1289ae9c
Autor:
Ewud Agborbesong, Julie Xia Zhou, Hongbing Zhang, Linda Xiaoyan Li, Peter C. Harris, James P. Calvet, Xiaogang Li
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6040 (2024)
The primary cilium is a microtubule-based sensory organelle that plays a critical role in signaling pathways and cell cycle progression. Defects in the structure and/or function of the primary cilium result in developmental diseases collectively know
Externí odkaz:
https://doaj.org/article/766b0b7680c0441f9cf9f8daa47e5930
Autor:
Ewud Agborbesong, Julie Xia Zhou, Hongbing Zhang, Linda Xiaoyan Li, Peter C. Harris, James P. Calvet, Xiaogang Li
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 603 (2024)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder worldwide and progresses to end-stage renal disease (ESRD). However, its precise mechanism is not fully understood. In recent years, epigenetic reprogra
Externí odkaz:
https://doaj.org/article/5c55ec817551433eaf550eaa1e543d53
Autor:
Julie Xia Zhou, Alice Shasha Cheng, Li Chen, Linda Xiaoyan Li, Ewud Agborbesong, Vicente E. Torres, Peter C. Harris, Xiaogang Li
Publikováno v:
Cells, Vol 13, Iss 6, p 489 (2024)
The progression of autosomal dominant polycystic kidney disease (ADPKD), an inherited kidney disease, is associated with renal interstitial inflammation and fibrosis. CD74 has been known not only as a receptor of macrophage migration inhibitory facto
Externí odkaz:
https://doaj.org/article/07564befe01d476eb3e7cebc11e020e1
Autor:
Dalia Zubidat, Christian Hanna, Amarjyot K. Randhawa, Byron H. Smith, Maroun Chedid, Daniel-Hasan N. Kaidbay, Luca Nardelli, Yaman G. Mkhaimer, Reem M. Neal, Charles D. Madsen, Sarah R. Senum, Adriana V. Gregory, Timothy L. Kline, Ziad M. Zoghby, Stephen M. Broski, Naim S. Issa, Peter C. Harris, Vicente E. Torres, Jad G. Sfeir, Fouad T. Chebib
Publikováno v:
Bone Reports, Vol 18, Iss , Pp 101655- (2023)
ADPKD is caused by pathogenic variants in PKD1 or PKD2, encoding polycystin-1 and -2 proteins. Polycystins are expressed in osteoblasts and chondrocytes in animal models, and loss of function is associated with low bone mineral density (BMD) and volu
Externí odkaz:
https://doaj.org/article/f14b4e1338eb4ca6b2a406927c9c0dc0
Autor:
Neveen A. Soliman, Mohamed A. Elmonem, Safaa M. Abdelrahman, Marwa M. Nabhan, Yosra A. Fahmy, Andrea Cogal, Peter C. Harris, Dawn S. Milliner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Primary hyperoxaluria (PH) is an autosomal recessive disorder of oxalate metabolism caused by pathogenic variants in either of three genes (AGXT, GRHPR or HOGA1). The study aimed at characterizing the clinical phenotypes as well as the genot
Externí odkaz:
https://doaj.org/article/dcb32cde93ad4e1ab60666323adc7bfa
Autor:
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov
Publikováno v:
Physiological Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Abstract Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐
Externí odkaz:
https://doaj.org/article/d19ebce73c984201a095278b38357db7
Autor:
Filippo Pinto e Vairo, Carri Prochnow, Jennifer L. Kemppainen, Emily C. Lisi, Joan M. Steyermark, Teresa M. Kruisselbrink, Pavel N. Pichurin, Rhadika Dhamija, Megan M. Hager, Sam Albadri, Lynn D. Cornell, Konstantinos N. Lazaridis, Eric W. Klee, Sarah R. Senum, Mireille El Ters, Hatem Amer, Linnea M. Baudhuin, Ann M. Moyer, Mira T. Keddis, Ladan Zand, David J. Sas, Stephen B. Erickson, Fernando C. Fervenza, John C. Lieske, Peter C. Harris, Marie C. Hogan
Publikováno v:
Kidney Medicine, Vol 3, Iss 5, Pp 785-798 (2021)
Rationale & Objective: The etiology of kidney disease remains unknown in many individuals with chronic kidney disease (CKD). We created the Mayo Clinic Nephrology Genomics Clinic to improve our ability to integrate genomic and clinical data to identi
Externí odkaz:
https://doaj.org/article/04c369ed9d8440b18c17f55de117a3b3
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Autosomal dominant polycystic kidney disease is characterized by the formation of cysts in the kidney. Here the authors show that cystic extracellular vesicles/exosomes play a critical role in regulating the biology and function of adjacent cells, in
Externí odkaz:
https://doaj.org/article/978a2efe63ee4aecbb0e7b5a78ffde38
Autor:
Mireille El Ters, Pengcheng Lu, Jonathan D. Mahnken, Jason R. Stubbs, Shiqin Zhang, Darren P. Wallace, Jared J. Grantham, Arlene B. Chapman, Vicente E. Torres, Peter C. Harris, Kyongtae Ty Bae, Douglas P. Landsittel, Frederic F. Rahbari-Oskoui, Michal Mrug, William M. Bennett, Alan S.L. Yu
Publikováno v:
Kidney International Reports, Vol 6, Iss 4, Pp 953-961 (2021)
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst growth and a loss of functioning renal mass, but a decline in glomerular filtration rate (GFR) and onset of end-stage renal disease (ESRD) occur l
Externí odkaz:
https://doaj.org/article/8beb5b69c3a14ce4bc60ffbad23c4ea5