Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Peter C. Fineran"'
Autor:
XinYue Wang, William J. Jowsey, Chen-Yi Cheung, Caitlan J. Smart, Hannah R. Klaus, Noon EJ Seeto, Natalie JE Waller, Michael T. Chrisp, Amanda L. Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P. West, Jason H. Yang, Peter C. Fineran, Gregory M. Cook, Simon A. Jackson, Matthew B. McNeil
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase. We hypothesise
Externí odkaz:
https://doaj.org/article/138d2c76fe9b40538e5e763113a839ee
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 10, Pp n/a-n/a (2024)
Abstract The efficiency of global crop production is under threat from microbial pathogens which is likely to be worsened by climate change. Major contributors to plant disease are Pseudomonas syringae (P. syringae) pathovars which affect a variety o
Externí odkaz:
https://doaj.org/article/fcd478bd2e4542d2aa68f685a27ed071
Autor:
Evan A. Schwartz, Jack P. K. Bravo, Mohd Ahsan, Luis A. Macias, Caitlyn L. McCafferty, Tyler L. Dangerfield, Jada N. Walker, Jennifer S. Brodbelt, Giulia Palermo, Peter C. Fineran, Robert D. Fagerlund, David W. Taylor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction1–5. Target RNA cleavage at regular intervals is characteristic of type
Externí odkaz:
https://doaj.org/article/df1f8e1485e54ad7bc5ecc11d0bc3d0e
Autor:
Lesley Sitter, Marion Schoof, Travis R. Glare, Murray P. Cox, Peter C. Fineran, Paul P. Gardner, Mark R. H. Hurst
Publikováno v:
MicrobiologyOpen, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract A soil bacterium in the Serratia genus, carrying a 153 kb conjugative amber disease‐associated plasmid (pADAP), is commercially exploited for population control of the New Zealand endemic pest beetle Costelytra giveni (Coleoptera: Scarabae
Externí odkaz:
https://doaj.org/article/5a610a7efe55480faa75a0c810a6675f
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112672- (2023)
Summary: Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids. However, MGEs can also impose a fitness cost due to their often
Externí odkaz:
https://doaj.org/article/068a955717ad4c4880ccdcdaa1a0bab8
Autor:
Evan A. Schwartz, Tess M. McBride, Jack P. K. Bravo, Daniel Wrapp, Peter C. Fineran, Robert D. Fagerlund, David W. Taylor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
I-D CRISPR-Cascade can target both single-stranded and double-stranded nucleic acids. Here, Schwartz et. al determine these structures and reveal large-scale rearrangements that allow for target discrimination and destruction.
Externí odkaz:
https://doaj.org/article/c6f9cd3cd7a84706b774e67908f2b1ed
Autor:
Rafael Pinilla-Redondo, Saadlee Shehreen, Nicole D. Marino, Robert D. Fagerlund, Chris M. Brown, Søren J. Sørensen, Peter C. Fineran, Joseph Bondy-Denomy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Mobile genetic elements have evolved anti-CRISPR (Acr) proteins to bypass the immunity provided by prokaryotic CRISPR–Cas systems. Here, the authors identify 11 type I Acrs encoded on mobile genetic elements, and show that acr loci neighborhoods ca
Externí odkaz:
https://doaj.org/article/d9475332a4d84a3d8ba6e1f2654da4ac
Autor:
Bridget N. J. Watson, Reuben B. Vercoe, George P. C. Salmond, Edze R. Westra, Raymond H. J Staals, Peter C. Fineran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Bacteria use CRISPR-Cas systems to protect themselves against viral infections. Here, Watson et al. show that a type I CRISPR-Cas system can induce abortive viral infection, where infected cells do not survive but viral propagation is decreased, thus
Externí odkaz:
https://doaj.org/article/b996789f39844bb4b36543b9bbb48b95
Autor:
Raymond H. J. Staals, Simon A. Jackson, Ambarish Biswas, Stan J. J. Brouns, Chris M. Brown, Peter C. Fineran
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Prokaryotic CRISPR-Cas systems provide adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, Staals et al. analyse millions of such events in a native CRISPR-Cas system, showing that newly
Externí odkaz:
https://doaj.org/article/2b405c24d7584a81b02d85c2c41648d7
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT A powerful contributor to prokaryotic evolution is horizontal gene transfer (HGT) through transformation, conjugation, and transduction, which can be advantageous, neutral, or detrimental to fitness. Bacteria and archaea control HGT and phag
Externí odkaz:
https://doaj.org/article/b1081660118546c791dce1a0a6a6135e