Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Peter C. F. Cheung"'
Autor:
David Ruiz-Carrillo, Jianqing Lin, Abbas El Sahili, Meng Wei, Siu Kwan Sze, Peter C. F. Cheung, Christian Doerig, Julien Lescar
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Malaria causes every year over half-a-million deaths. The emergence of parasites resistant to available treatments makes the identification of new targets and their inhibitors an urgent task for the development of novel anti-malaria drugs. P
Externí odkaz:
https://doaj.org/article/58ab85b505ca437a9526f9ae8fbfbcc3
Autor:
Siu Kwan Sze, Peter C. F. Cheung, Yin Hoe Yau, Aminahtusaidah Said, David Ruiz-Carrillo, Jianqing Lin, Ramya Chandrasekaran, Susana Geifman Shochat, Julien Lescar, Kang Sun, Liang Dai
Publikováno v:
Biochemical and Biophysical Research Communications. 513:714-720
Pellino1 is an E3 ubiquitin ligase that plays a key role in positive regulation of innate immunity signaling, specifically required for the production of interferon when induced by viral double-stranded RNA. We report the identification of the tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d25d9d61372257ebce3758a04d9dbf
https://doi.org/10.1016/j.bbrc.2019.03.095
https://doi.org/10.1016/j.bbrc.2019.03.095
Autor:
Richard Sutejo, Dawn S Yeo, Myint Zu Myaing, Chen Hui, Jiajia Xia, Debbie Ko, Peter C F Cheung, Boon-Huan Tan, Richard J Sugrue
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33732 (2012)
The host response to the low pathogenic avian influenza (LPAI) H5N2, H5N3 and H9N2 viruses were examined in A549, MDCK, and CEF cells using a systems-based approach. The H5N2 and H5N3 viruses replicated efficiently in A549 and MDCK cells, while the H
Externí odkaz:
https://doaj.org/article/4c14bad3343c4ca0b88f2bec57731365
Autor:
Julien Lescar, David Ruiz-Carrillo, Abbas El Sahili, Siu Kwan Sze, Jianqing Lin, Christian Doerig, Meng Wei, Peter C. F. Cheung
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Malaria causes every year over half-a-million deaths. The emergence of parasites resistant to available treatments makes the identification of new targets and their inhibitors an urgent task for the development of novel anti-malaria drugs. Protein ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ec65dcc09caa9b657445e8c5413ba8
https://doi.org/10.1038/s41598-018-25738-5
https://doi.org/10.1038/s41598-018-25738-5
Autor:
Edward G. McIver, Peter C. F. Cheung, Christiane Ruedl, Liang Dai, Cheah-Chen Seh, Robert Gourlay, Philip Cohen, Julien Lescar, Simon Morton, Aye-Thu Chan, Insaf A. Qureshi, Eddy T. H. Goh, Joanne Hough, Xin-Yu Liu, Hilary Smith, Jiajia Xi
Publikováno v:
Biochemical Journal. 434:537-548
Mammalian Pellino isoforms are phosphorylated by IRAK (interleukin receptor associated kinase) 1/IRAK4 in vitro, converting them into active E3 ubiquitin ligases. In the present paper we report a striking enhancement in both transcription of the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41060ccc84c99bb056e49d39347f944
https://doi.org/10.1042/bj20101421
https://doi.org/10.1042/bj20101421
Autor:
Mark B Y Tang, Chee Ren Ivan Lam, Nguan Soon Tan, Siew Hwey Tan, Ming Jie Tan, Peter C. F. Cheung
Publikováno v:
Cell Death & Differentiation. 18:1120-1129
Dysregulated reactive oxygen species (ROS) generation contributes to many human pathologies, including cancer and diabetes. During normal wound repair, inflammation-induced ROS production must be tightly controlled, but the mechanisms reining their g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cbdf887b60de29c90f888315bad87e
https://doi.org/10.1038/cdd.2010.182
https://doi.org/10.1038/cdd.2010.182
Autor:
Yan Yih Goh, Fong U. Tam, Jamie Wei Ting Teo, Nguan Soon Tan, Marc Hai Liang Wong, Siew Hwey Tan, Han Chung Chong, Mintu Pal, Mark B Y Tang, Peter C. F. Cheung, Ming Jie Tan, Chek Kun Tan
Publikováno v:
Journal of Biological Chemistry. 284:18047-18058
Skin maintenance and healing after wounding requires complex epithelial-mesenchymal interactions purportedly mediated by growth factors and cytokines. We show here that, for wound healing, transforming growth factor-beta-activated kinase 1 (TAK1) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e756c0f50cc6cc87369e1d009bfdb725
https://doi.org/10.1074/jbc.m109.002691
https://doi.org/10.1074/jbc.m109.002691
Autor:
Susana Llanos, Ana Cuadrado, Vanesa Lafarga, Peter C. F. Cheung, Angel R. Nebreda, Philip Cohen, Ignacio Dolado
Publikováno v:
The EMBO Journal. 26:2115-2126
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in stress-induced cell-fate decisions by orchestrating responses that go from cell-cycle arrest to apoptosis. We have identified a new p38 MAPK-regulated protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1011a6717bae37842e27448113fd9d92
https://doi.org/10.1038/sj.emboj.7601657
https://doi.org/10.1038/sj.emboj.7601657
Publikováno v:
Biochemical Journal. 378:27-34
We have identified a new binding partner of the TGFbeta (transforming growth factor-beta)-activated protein kinase (TAK1), termed TAB3 (TAK1-binding protein-3), which shares 48% amino acid sequence identity with TAB2. Our results indicate that two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f282c8cff4967ea86cf13a84e07b3
https://doi.org/10.1042/bj20031794
https://doi.org/10.1042/bj20031794
Autor:
Saurabh Saha, Kathryn R. Meshaw, Peter C. F. Cheung, Avery S. McMurry, Jeffrey James Roix, S. D. Harrison, Elizabeth Rainbolt
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e101708 (2014)
PLoS ONE
PLoS ONE
Approved drugs target approximately 400 different mechanisms of action, of which as few as 60 are currently used as anti-cancer therapies. Given that on average it takes 10–15 years for a new cancer therapeutic to be approved, and the recent succes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab5afbb4a525e738e3d391352fb07e3
http://europepmc.org/articles/PMC4122340?pdf=render
http://europepmc.org/articles/PMC4122340?pdf=render