Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Peter C. Bragt"'
Publikováno v:
American Journal of Industrial Medicine. 20:175-194
Methyl n-butyl ketone (MBK) was considered rather harmless until an outbreak of peripheral neuropathy occurred in 1973 among workers exposed to MBK. MBK easily penetrates the skin; pulmonary retention is approximately 80-85% in man. Distribution is w
Autor:
Peter C. Bragt
Publikováno v:
The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals ISBN: 9789048161478
In 1997, the Netherlands Society of Toxicology organized a symposium chaired by Dr. Henk Derks of the National Institute of Public Health and the Environment (RIVM1) under the provocative title: “PBPK models: where’s the beef?”. The themes of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::227eb9c8f0eb36caffeea59acf9b1fc4
https://doi.org/10.1007/978-94-017-3437-0_7
https://doi.org/10.1007/978-94-017-3437-0_7
Autor:
Peter C. Bragt
Publikováno v:
Agents and Actions. 15:53-56
The discovery that an anti-inflammatory copper-zinc protein from bovine liver was a scavenger of superoxide-free radicals led to the concept of free radical-mediated damage as a mechanism underlying inflammation. The present paper discusses some rece
Autor:
Peter C. Bragt, Ivan L. Bonta
Publikováno v:
Agents and Actions. 10:536-539
Local oxidative changes have been investigated during granulomatous inflammation in the rat. Lipid peroxidation occurred independently of the prostaglandin biosynthetic pathways in the kaolin granuloma pouch model. Elevated levels of malonaldehyde, T
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 677:165-173
Metyrapone and SKF-525A, together with amphenone B, a structural analogue of metyrapone, which are all inhibitors of cytochrome P-450-mediated reactiors, were shown to inhibit the arachidonic acid-induced aggregation of human platelets. Amphenone B,
Publikováno v:
Agents and Actions. 7:539-544
Granuloma formation was studied in rats following s.c. implantation of polyether sponges soaked in carrageenin. Sponges, which had been boiled in ethanol, produced larger granulomata and more exudate than unboiled sponges, but prostaglandin (PG) conc
Publikováno v:
The Annals of Occupational Hygiene.
Publikováno v:
Progress in Medicinal Chemistry ISBN: 9780720406696
Publisher Summary This chapter discusses anti-rheumatic drugs. The broadly accepted views on anti-rheumatic drugs in present clinical use have been discussed mainly as background information. The side effects of clinically used anti-rheumatic drugs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2429a383d73321b4e41be15f8ecee61f
https://doi.org/10.1016/s0079-6468(08)70160-7
https://doi.org/10.1016/s0079-6468(08)70160-7
Publikováno v:
Inflammatory Diseases and Copper ISBN: 9781461258315
One of the features at the molecular level of inflammatory disorders is the enhanced peroxidative conversion of polyunsaturated fatty acids, both enzymatically, to prostaglandins, thromboxane and (poly)hydroxy-fatty acids, and also nonenzymatically.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1be409d0bb06c89b569ed1408ee75609
https://doi.org/10.1007/978-1-4612-5829-2_24
https://doi.org/10.1007/978-1-4612-5829-2_24
Autor:
Ivan L. Bonta, Peter C. Bragt
Publikováno v:
Biochemical pharmacology. 28(10)
The metabolism of [1-14C]arachidonic acid was studied in vivo during the development of carrageenin-induced granuloma in the rat. For this purpose a double-cannulated teflon cylinder was implanted into the dorsal subdermal tissue of rats, and the can