Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter C. Bonnette"'
Autor:
Brosius Arthur Douglas, Peter C. Bonnette, Leonard Buckbinder, Amy P. Baumann, Brett S. Robinson, Matthew P. Stokes, Jeffrey C. Silva
Publikováno v:
Journal of Proteomics. 73:1306-1320
The PYK2 tyrosine kinase is a negative regulator of bone formation, but aside from the requirement for PYK2 kinase activity there has been little progress toward understanding of the molecular mechanism involved in this function. To gain insight into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6882a812d29848fc5404d52f1ade2a6f
https://doi.org/10.1016/j.jprot.2010.01.011
https://doi.org/10.1016/j.jprot.2010.01.011
Autor:
Daniel P. Walker, Daniel W. Kung, Anil Mistry, Michael P. Zawistoski, Seungil Han, Jian-Cheng Li, Janet A. Houser, Jason Boer, Amy P. Baumann, Leonard Buckbinder, Molly A. McGlynn, Peter C. Bonnette, Angel Guzman-Perez, Li Xing
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3253-3258
The synthesis, in vitro properties, and in vivo pharmacokinetics for a series of sulfoximine-substituted trifluoromethylpyrimidines as inhibitors of proline-rich tyrosine kinase, a target for the possible treatment of osteoporosis, are described. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f40c7f299d748ce7e78354bf6d599f
https://doi.org/10.1016/j.bmcl.2009.04.093
https://doi.org/10.1016/j.bmcl.2009.04.093
Autor:
Linda S. Wood, Maruja E. Lira, Thomas B. Freeman, David B. Lloyd, Gregory M. Preston, L. Kathryn Durham, Patrice M. Milos, Anthony J. Lanzetti, Peter C. Bonnette, Xiayang Qiu, John F. Thompson, Eliot Sugarman
Publikováno v:
Journal of Biological Chemistry. 280:14918-14922
Cholesteryl ester transfer protein (CETP) is an important modulator of high density lipoprotein cholesterol in humans and thus considered to be a therapeutic target for preventing cardiovascular disease. The gene encoding CETP has been shown to be hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaf58c993324f1feb8b32720e84e401
https://doi.org/10.1074/jbc.m500523200
https://doi.org/10.1074/jbc.m500523200
Publikováno v:
Development. 131:2715-2725
Steroid signaling underlies developmental processes in animals. Mutations that impair steroidogenesis in the fruit fly Drosophila melanogaster provide tools to dissect steroid hormone action genetically. The widely used temperature-sensitive mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f10396a330ddebe0451d376f2e1662
https://doi.org/10.1242/dev.01143
https://doi.org/10.1242/dev.01143
Publikováno v:
Development. 127:3249-3261
The E2F family of transcription factors contributes to cell cycle control by regulating the transcription of DNA replication factors. Functional ‘E2F’ is a DNA-binding heterodimer composed of E2F and DP proteins. Drosophila contains two E2F genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0dd4e1393d137d2ea2551c4bddc18d0
https://doi.org/10.1242/dev.127.15.3249
https://doi.org/10.1242/dev.127.15.3249
Autor:
David Christopher Ebner, Paula M. Loria, David Hepworth, Edward L. Conn, Janice E. Chin, Lucy Rogers, Kevin J. Filipski, Philip A. Carpino, Shawn Cabral, Maria A. Vanvolkenburg, Lisa D. Norquay, John R. Hadcock, Aaron C. Smith, Kimberly O. Cameron, Markus Boehm, Esther C.Y. Lee, Denise Gautreau, Martin B. Brenner, Michelle Morin, Peter C. Bonnette, Alan M. Mathiowetz
Publikováno v:
ACS medicinal chemistry letters. 4(11)
Orphan G protein-coupled receptors (oGPCRs) are a class of integral membrane proteins for which endogenous ligands or transmitters have not yet been discovered. Transgenic animal technologies have uncovered potential roles for many of these oGPCRs, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a5c70827eaf9ee6457e2a5c2df0f81
https://pubmed.ncbi.nlm.nih.gov/24900608
https://pubmed.ncbi.nlm.nih.gov/24900608
Autor:
Matthew F. Dunn, John Charles Kath, Anil Mistry, F. Christopher Bi, Daniel Tyler Richter, Sabrina X. Zhao, Leonard Buckbinder, Jacquelyn Klug-McLeod, Daniel W. Kung, Gary Erik Aspnes, Michael P. Zawistoski, Robert M. Oliver, Seungil Han, Peter C. Bonnette, Ethan Ung, Molly A. McGlynn, Angel Guzman-Perez, Catherine Angela Hulford, Matthew C. Griffor, John R. Soglia, Jonathan N. Bauman, Michael Joseph Luzzio, Daniel P. Walker, Christopher Autry, Amit S. Kalgutkar, W. Gregory Roberts, Jian-Cheng Li, Beth Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
The synthesis and SAR for a series of diaminopyrimidines as PYK2 inhibitors are described. Using a combination of library and traditional medicinal chemistry techniques, a FAK-selective chemical series was transformed into compounds possessing good P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d4e40768ab5124987956906e550066
https://pubmed.ncbi.nlm.nih.gov/18951788
https://pubmed.ncbi.nlm.nih.gov/18951788
Autor:
Lydia C. Pan, Vishwas M. Paralkar, D.T. Crawford, Thomas A. Owen, Thomas A. Brown, Kelly R. Long, Steven L. Smock, John E. Hambor, Mei Li, Peter C. Bonnette, Leonard Buckbinder, John Charles Kath, W. Gregory Roberts, David F. Gebhard, Hollis A. Simmons, Angel Guzman-Perez, Michael Joseph Luzzio, Catherine Angela Hulford, Hua Zhu Ke, Amy P. Baumann, Lisa M. Olson, Hong Qi, William A. Grasser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(25)
Bone is accrued and maintained primarily through the coupled actions of bone-forming osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-rich tyrosine kinase 2 (PYK2) is a positive mediator of osteoclast fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bced4831fc4cac3ea1ee6f697503c8c4
https://pubmed.ncbi.nlm.nih.gov/17581868
https://pubmed.ncbi.nlm.nih.gov/17581868
Publikováno v:
Biochemistry. 45(43)
Cholesteryl ester transfer protein (CETP), bactericidal/permeability inducing protein (BPI), and lipopolysaccharide binding protein (LBP) are members of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) family of proteins that share a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd45d4f625cee53bea5365645907fdbb
https://pubmed.ncbi.nlm.nih.gov/17059212
https://pubmed.ncbi.nlm.nih.gov/17059212
Publikováno v:
Development (Cambridge, England). 128(24)
Drosophila contains two members of the E2F transcription factor family (E2f and E2f2), which controls the expression of genes that regulate the G1-S transition of the cell cycle. Previous genetic analyses have indicated that E2f is an essential gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27b2930e35c2e4f5fc939ee817d2965
https://pubmed.ncbi.nlm.nih.gov/11748144
https://pubmed.ncbi.nlm.nih.gov/11748144