Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Peter C. Dedon"'
Autor:
Nick K. Davis, Yok Hian Chionh, Megan E. McBee, Fabian Hia, Duanduan Ma, Liang Cui, Mariam Lucila Sharaf, Weiling Maggie Cai, Watthanachai Jumpathong, Stuart S. Levine, Sylvie Alonso, Peter C. Dedon
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mycobacteria adapt to infection stresses by entering a reversible non-replicating persistence (NRP) with slow or no cell growth and broad antimicrobial tolerance. Hypoxia and nutrient deprivation are two well-studied stresses commonly used t
Externí odkaz:
https://doaj.org/article/f8fddf70d57c4a719df9e9dd98168d53
Autor:
Lulu Jiang, Rebecca Roberts, Melissa Wong, Lushuang Zhang, Chelsea Joy Webber, Jenna Libera, Zihan Wang, Alper Kilci, Matthew Jenkins, Alejandro Rondón Ortiz, Luke Dorrian, Jingjing Sun, Guangxin Sun, Sherif Rashad, Caroline Kornbrek, Sarah Anne Daley, Peter C. Dedon, Brian Nguyen, Weiming Xia, Takashi Saito, Takaomi C. Saido, Benjamin Wolozin
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionThe study of the pathophysiology study of Alzheimer’s disease (AD) has been hampered by lack animal models that recapitulate the major AD pathologies, including extracellular -amyloid (A) deposition, intracellular aggregation of microtu
Externí odkaz:
https://doaj.org/article/b7557e4ad4e346968ea1ea10bd07ae48
Autor:
Samia Quaiyum, Jingjing Sun, Virginie Marchand, Guangxin Sun, Colbie J. Reed, Yuri Motorin, Peter C. Dedon, Michael F. Minnick, Valérie de Crécy-Lagard
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Transfer RNA (tRNA) modifications play a crucial role in maintaining translational fidelity and efficiency, and they may function as regulatory elements in stress response and virulence. Despite their pivotal roles, a comprehensive mapping of tRNA mo
Externí odkaz:
https://doaj.org/article/2b175cc03c7547cbb00c234e3ce585c6
Autor:
Satoshi Kimura, Veerasak Srisuknimit, Kacie L. McCarty, Peter C. Dedon, Philip J. Kranzusch, Matthew K. Waldor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
C-to-Ψ conversion is a previously uncharacterized form of base editing. Here, the authors describe how the TrcP enzyme catalyzes this process in a stepwise fashion and how this editing process is controlled by a network of modifications and nutrient
Externí odkaz:
https://doaj.org/article/fb3674c997cd46d2bf5e9c008d0b569d
Autor:
Taylor Wadley, Sun Hee Moon, Michael S. DeMott, Visanu Wanchai, En Huang, Peter C. Dedon, Gunnar Boysen, Intawat Nookaew
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Bacterial DNA is subject to various modifications involved in gene regulation and defense against bacteriophage attacks. Phosphorothioate (PT) modifications are protective modifications in which the non-bridging oxygen in the DNA phosphate backbone i
Externí odkaz:
https://doaj.org/article/0de20ba09afe4a868070b14e4b343c4a
Autor:
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Publikováno v:
Epigenetics, Vol 15, Iss 10, Pp 1121-1138 (2020)
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alk
Externí odkaz:
https://doaj.org/article/d464ab1c8bef4c1bb173527d6328c626
Autor:
Maria C. Ferreira dos Santos, Cole P. Anderson, Susanne Neschen, Kimberly B. Zumbrennen-Bullough, Steven J. Romney, Melanie Kahle-Stephan, Birgit Rathkolb, Valerie Gailus-Durner, Helmut Fuchs, Eckhard Wolf, Jan Rozman, Martin Hrabe de Angelis, Weiling Maggie Cai, Malini Rajan, Jennifer Hu, Peter C. Dedon, Elizabeth A. Leibold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Iron metabolism is linked to type 2 diabetes. Here the authors describe a mechanism through which cellular iron deficiency caused by loss of Irp2 impairs Cdkal1 function, resulting in inaccurate proinsulin translation, impaired proinsulin processing
Externí odkaz:
https://doaj.org/article/53f26f3f35f1461a9fc51b7c51673141
Autor:
Geoffrey Hutinet, Witold Kot, Liang Cui, Roman Hillebrand, Seetharamsingh Balamkundu, Shanmugavel Gnanakalai, Ramesh Neelakandan, Alexander B. Carstens, Chuan Fa Lui, Denise Tremblay, Deborah Jacobs-Sera, Mandana Sassanfar, Yan-Jiun Lee, Peter Weigele, Sylvain Moineau, Graham F. Hatfull, Peter C. Dedon, Lars H. Hansen, Valérie de Crécy-Lagard
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Viral genomic DNA is often modified to evade the host bacterial restriction system. Here the authors identified 2′-deoxy-7-deazaguanine modifications on phage DNA by comparative genomics and experimental validation, showing their role in genome pro
Externí odkaz:
https://doaj.org/article/e39fa27a9a6549e3ab545c4ecd3af0e2
Autor:
Lotem Sarid, Jingjing Sun, Jurairat Chittrakanwong, Meirav Trebicz-Geffen, Jun Ye, Peter C. Dedon, Serge Ankri
Publikováno v:
Cells, Vol 11, Iss 16, p 2509 (2022)
Queuosine (Q) is a naturally occurring modified nucleoside that occurs in the first position of transfer RNA anticodons such as Asp, Asn, His, and Tyr. As eukaryotes lack pathways to synthesize queuine, the Q nucleobase, they must obtain it from thei
Externí odkaz:
https://doaj.org/article/b4a38627c41249f6b9548da8e851619a
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and
Externí odkaz:
https://doaj.org/article/a293763e26db4303bfaea6bace763753