Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Peter C Verveer"'
Autor:
Peter C Verveer, Bob Stork, Hein K. A. C. Coolen, Alice J.M. Borst, Josephus H. M. Lange, Martina A.W. van der Neut, Chris G. Kruse
Publikováno v:
Journal of Medicinal Chemistry. 53:1338-1346
Pyrazolines 7-10 were designed as novel CB(1) receptor antagonists, which exhibited improved turbidimetric aqueous solubilities. On the basis of their extended CB(1) antagonist pharmacophore, hybrid molecules exhibiting cannabinoid CB(1) receptor ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a17a640414c9826697d448ffeea4e10
https://doi.org/10.1021/jm901614b
https://doi.org/10.1021/jm901614b
Autor:
Peter C Verveer, Herman H. van Stuivenberg, Josephus H. M. Lange, Wouter de Looff, Alice J.M. Borst, Willem Veerman, Hiskias G. Keizer, Hein K. A. C. Coolen, Andrew C. McCreary, Henri C. Wals, Chris G. Kruse, Tiny J.P. Adolfs
Publikováno v:
Journal of Medicinal Chemistry. 48:1823-1838
Series of thiazoles, triazoles, and imidazoles were designed as bioisosteres, based on the 1,5-diarylpyrazole motif that is present in the potent CB(1) receptor antagonist rimonabant (SR141716A, 1). A number of target compounds was synthesized and ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcd4c8ade0a6c0b52c26817f2895e9e
https://doi.org/10.1021/jm040843r
https://doi.org/10.1021/jm040843r
Autor:
Arnold P. den Hartog, Dijksman Jessica A R, Koos Tipker, Hiskias G. Keizer, Hein K. A. C. Coolen, Henri C. Wals, Tiny J.P. Adolfs, Bob Stork, Peter C Verveer, Andrew C. McCreary, Josephus H. M. Lange, Natasja M J de Jong, Herman H. van Stuivenberg, Jan Hoogendoorn, Chris G. Kruse, Arnoud H.J. Herremans, Eric Ronken, Willem Veerman
Publikováno v:
Journal of Medicinal Chemistry. 47:627-643
A series of novel 3,4-diarylpyrazolines was synthesized and evaluated in cannabinoid (hCB(1) and hCB(2)) receptor assays. The 3,4-diarylpyrazolines elicited potent in vitro CB(1) antagonistic activities and in general exhibited high CB(1) vs CB(2) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf7d3905b901be5418d4523216fb0d
https://doi.org/10.1021/jm031019q
https://doi.org/10.1021/jm031019q
Autor:
Feenstra Roelof W, Peter C Verveer, Stefan J. M. Osnabrug, Josephus H. M. Lange, Floris A. S. Hout, Lovina J. F. Hofmeyer, Chris G. Kruse
Publikováno v:
Tetrahedron Letters. 43:1101-1104
An unprecedented microwave-enhanced Goldberg reaction constitutes the key strategic step in the synthesis of N-arylpiperazinones, N-arylpiperazinediones and N-aryl-3,4-dihydroquinolinones. Microwave irradiation greatly accelerates the Goldberg reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::579e09b9ee78a475c688715b43c63136
https://doi.org/10.1016/s0040-4039(01)02334-6
https://doi.org/10.1016/s0040-4039(01)02334-6
Publikováno v:
Tetrahedron Letters. 42:1367-1369
3-Aryl-4-hydroxyquinolin-2(1 H )-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77625efaddcafe4f0c25654f5d2666cb
https://doi.org/10.1016/s0040-4039(00)02244-9
https://doi.org/10.1016/s0040-4039(00)02244-9
Publikováno v:
ChemInform. 32
3-Aryl-4-hydroxyquinolin-2(1 H )-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4ef68f41333f406f7544debec511146
https://doi.org/10.1002/chin.200122105
https://doi.org/10.1002/chin.200122105
Autor:
Feenstra Roelof W, Floris A. S. Hout, Chris G. Kruse, Josephus H. M. Lange, Peter C Verveer, Stefan J. M. Osnabrug, Lovina J. F. Hofmeyer
Publikováno v:
ChemInform. 33
An unprecedented microwave-enhanced Goldberg reaction constitutes the key strategic step in the synthesis of N-arylpiperazinones, N-arylpiperazinediones and N-aryl-3,4-dihydroquinolinones. Microwave irradiation greatly accelerates the Goldberg reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb8d1870c7fa71b39be064ad23b615e
https://doi.org/10.1002/chin.200223178
https://doi.org/10.1002/chin.200223178