Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Peter C Kind"'
Autor:
Tara L Mastro, Anthony Preza, Shinjini Basu, Sumantra Chattarji, Sally M Till, Peter C Kind, Mary B Kennedy
Publikováno v:
eLife, Vol 9 (2020)
SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of Syngap1 in mice is correlated with increased steady-state levels of other key PSD proteins t
Externí odkaz:
https://doaj.org/article/a09aac89c04d418884f82e7fb1029d4d
Autor:
Laura Simões de Oliveira, Heather E. O’Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C. Davenport, Paul Baxter, Susana R. Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K. Osterweil, Giles E. Hardingham, Michael A. Cousin, Sumantra Chattarji, Sam A. Booker, Tim A. Benke, David J. A Wyllie, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Mutations in the X-linked gene cyclin-dependent kinase-like 5 (CDKL5) cause a severe neurological disorder characterised by early-onset epileptic seizures, autism and intellectual disability (ID). Impaired hippocampal function has
Externí odkaz:
https://doaj.org/article/ae255dae432e41748c4459655b5be30f
Autor:
Owen Dando, Jamie McQueen, Karen Burr, Peter C. Kind, Siddharthan Chandran, Giles E. Hardingham, Jing Qiu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Rodent studies have shown that alternative splicing in neurons plays important roles in development and maturity, and is regulatable by signals such as electrical activity. However, rodent-human similarities are less well explored. We compared basal
Externí odkaz:
https://doaj.org/article/ce260b833ff24902a5ce953b3917db8a
Autor:
Jing Qiu, Jamie McQueen, Bilada Bilican, Owen Dando, Dario Magnani, Karolina Punovuori, Bhuvaneish T Selvaraj, Matthew Livesey, Ghazal Haghi, Samuel Heron, Karen Burr, Rickie Patani, Rinku Rajan, Olivia Sheppard, Peter C Kind, T Ian Simpson, Victor LJ Tybulewicz, David JA Wyllie, Elizabeth MC Fisher, Sally Lowell, Siddharthan Chandran, Giles E Hardingham
Publikováno v:
eLife, Vol 5 (2016)
Evolutionary differences in gene regulation between humans and lower mammalian experimental systems are incompletely understood, a potential translational obstacle that is challenging to surmount in neurons, where primary tissue availability is poor.
Externí odkaz:
https://doaj.org/article/c6d2491c1b8445d08c27122e7a5f0b19
Autor:
Nóra M Márkus, Philip Hasel, Jing Qiu, Karen F S Bell, Samuel Heron, Peter C Kind, Owen Dando, T Ian Simpson, Giles E Hardingham
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148164 (2016)
Uptake of Ca2+ into the mitochondrial matrix controls cellular metabolism and survival-death pathways. Several genes are implicated in controlling mitochondrial Ca2+ uptake (mitochondrial calcium regulatory genes, MCRGs), however, less is known about
Externí odkaz:
https://doaj.org/article/6a94a37ca5b44653a8bc8cc703f9f8d1
Autor:
Ralph D Hector, Owen Dando, Nicoletta Landsberger, Charlotte Kilstrup-Nielsen, Peter C Kind, Mark E S Bailey, Stuart R Cobb
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157758 (2016)
Mutations in the X-linked Cyclin-Dependent Kinase-Like 5 gene (CDKL5) cause early onset infantile spasms and subsequent severe developmental delay in affected children. Deleterious mutations have been reported to occur throughout the CDKL5 coding reg
Externí odkaz:
https://doaj.org/article/9a584d0583cf4017904a95080225be63
Publikováno v:
Frontiers in Systems Neuroscience, Vol 17 (2023)
Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to non-motor realms, such as fear-based emotional processing and that these functions are supporte
Externí odkaz:
https://doaj.org/article/fc3dc02dc44d4dc4b108e9cd2f4d1769
Autor:
Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price, Thomas Pratt
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex is hypothesised
Externí odkaz:
https://doaj.org/article/94e25852ab114ae8b3fe8bb4a3c913b2
Autor:
Antonis Asiminas, Sam A. Booker, Owen R. Dando, Zrinko Kozic, Daisy Arkell, Felicity H. Inkpen, Anna Sumera, Irem Akyel, Peter C. Kind, Emma R. Wood
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-29 (2022)
Abstract Background Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks of FXS with affected individuals showing extreme difficulty adapting t
Externí odkaz:
https://doaj.org/article/e0dabc1eced84dd8ab6b7b80f7f03aae
Autor:
Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however
Externí odkaz:
https://doaj.org/article/3d9e90cbc8e047a6a47ce223c07a8fd8