Detection and utility of cell-free and circulating tumour DNA in bone and soft-tissue sarcomas

Autor: Kim M. Tsoi, Nalan Gokgoz, Paige Darville-O'Quinn, Patrick Prochazka, Ainaz Malekoltojari, Anthony M. Griffin, Peter C. Ferguson, Jay S. Wunder, Irene L. Andrulis

Publikováno v: Bone & Joint Research, Vol 10, Iss 9, Pp 602-610 (2021)

Aims: Cell-free DNA (cfDNA) and circulating tumour DNA (ctDNA) are used for prognostication and monitoring in patients with carcinomas, but their utility is unclear in sarcomas. The objectives of this pilot study were to explore the prognostic signif

Externí odkaz: https://doaj.org/article/a6e0838cdcba4748a65761405ec7b170

Giant cell tumour of bone

Autor: Ahmed Aoude, David Nikomarov, Jonathan R. Perera, Izuchukwu K. Ibe, Anthony M. Griffin, Kim M. Tsoi, Peter C. Ferguson, Jay S. Wunder

Publikováno v: The Bone & Joint Journal. :559-567

AimsGiant cell tumour of bone (GCTB) is a locally aggressive lesion that is difficult to treat as salvaging the joint can be associated with a high rate of local recurrence (LR). We evaluated the risk factors for tumour relapse after treatment of a G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d3a8a4438bf8e9f305393c59d69f246
https://doi.org/10.1302/0301-620x.105b5.bjj-2022-1231.r1

A Size-Based Criteria for Flap Reconstruction After Thigh-Adductor, Soft-Tissue Sarcoma Resection

Autor: Rostislav Novak, Jennifer L. Nevin, Philip D. Rowell, Anthony Griffin, Sergey Mazin, Stefan O. P. Hofer, Anne C. O’Neill, Kim Tsoi, Peter C. Ferguson, Jay S. Wunder

Publikováno v: Annals of Surgical Oncology. 30:3701-3711

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58480071e17038030c5e87aea0e00a29
https://doi.org/10.1245/s10434-023-13261-5

Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activation

Autor: Jay S. Wunder, Minji J. Lee, Junghyun Nam, Beatrice Y. Lau, Brendan C. Dickson, Dushanthi Pinnaduwage, Shelley B. Bull, Peter C. Ferguson, Andrew Seto, Nalan Gokgoz, Irene L. Andrulis

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

Immune checkpoint proteins, such as PD-L1 and PD-1, are important in several cancers; however, their role in osteosarcoma (OSA) and soft tissue sarcoma (STS) remains unclear. Our aims were to determine whether subsets of OSA/STS harbor tumor-infiltra

Externí odkaz: https://doaj.org/article/0026928f059a4331a52a64db61b3b10a

C-CASE 2022: Competence to Excellence01. The Queen Bee phenomenon in Canadian surgical subspecialties: an evaluation of gender biases in the resident training environment02. Barriers to surgical peer coaching — What have we learned, and where do we go from here?03. Shared decision-making and evidence-based medicine: Pivotal or trivial to patient care in orthopedic trauma?04. Immersive virtual reality and cadaveric bone are equally effective in skeletal anatomy education: a randomized crossover noninferiority trial05. Development of simulators for decentralized simulation-based education IO training using design thinking and Delphi — a novel approach06. The impact of feedback on laparoscopic skills for surgical residents during COVID-1907. The role of collaborative feedback and remote practice in the acquisition of suturing skills by medical students at Université de Montréal08. Efficacy testing of an affordable and realistic small bowel simulator for hand-sewn anastomosis09. The LASER rating scale: a new teaching tool in otolaryngology10. Virtual patient case simulations: their role in undergraduate and postgraduate surgical training11. Evaluating the effectiveness of video-assisted informed consent in surgery: a systematic review12. Communication patterns in the cardiac surgery operating room are affected by task difficulty: a simulation model13. Improving adherence to postcall departure guidelines in orthopedics: a quality-improvement initiative14. Increasing familiarity among team members helps to reduce laparoscopic procedure time15. The effectiveness of a self-directed online learning module on trainee knowledge and confidence during plastic surgery clinical rotations16. Implementing an orientation handbook before a surgical rotation in urology17. An examination of equity-related experiences of surgical trainees at academic centres across Ontario: design of a targeted needs assessment18. Viewing differences between experts and trainees: implication for surgical education19. Assessment of medical student exposure to and satisfaction with surgical subspecialty education20. Assessment of student exposure to climate impacts of surgical personal protective equipment in the undergraduate medical curriculum21. Virtual reality simulation for the middle cranial fossa approach — a face, content and construct validation study22. Evaluating the Canadian Orthopaedic Surgery Medical Education Course (COSMEC)23. Subpial resection in a novel ex vivo calf brain epilepsy simulation model24. Effectiveness of the Eyesi augmented reality simulator for ophthalmology trainees: a systematic review and meta-analysis25. Learning beyond the objectives: an evidence-based analysis of AI-selected competencies in surgical simulation training26. Virtual compared with in-person surgical grand rounds: participants’ perceptions, preferences and directions for the future27. Quality of narrative feedback for entrustable professional activities assessed in the operating room: analysis of 4. years of assessments in the surgical foundations curriculum at Queen’s University28. SimOscopy: an accessible 3D-printed and laser-cut laparoscopic surgical simulator developed for a mobile device29. A debriefing tool to acquire nontechnical skills in trauma courses30. Capacity building using a hub-and-spokes model to produce customizable simulators for surgical education31. Exploring skin tone diversity in a plastic surgery resident education curriculum32. Video-based assessments of thoracic surgery trainees’ operative skills as adjuncts in competency-based medical education33. How do you feel? An examination of team leaders’ and members’ emotions in surgical simulations34. Comparing the efficacy of a real-time intelligent coaching system to human expert instruction in surgical technical skills training: randomized controlled trial35. Empowering women to pursue surgery: launching a pilot gender-congruent mentorship program for medical students36. Affective and cognitive responses to a virtual reality spine simulator37. Immersive virtual reality for patient-specific preoperative planning: a systematic review38. The categorization of surgical problems by junior and senior medical students39. The application of microlearning modules in surgical education to enhance procedural skills and surgical training40. Authorship gender disparity and trends in female authorship in 5 high-impact orthopedic journals from 2002 to 202241. The landscape of Canadian academic surgery: analysis of gender representation, academic rank, and research productivity

Autor: Stuti M. Tanya, Reva Qiu, Basmah AlTinawi, Mathew N. Hindi, Trisha Tee, Sheharzad Mahmood, Recai Yilmaz, Keerat Grewal, Nicole Stachura, Raahulan Rathagirishnan, Julia Micallef, Fabio Botelho, Stephanie Roberts, Rosephine Del Fernandes, Giuseppe Retrosi, Ali M. Fazlollahi, Lauren Carr, Nour Abou Hamdan, Anser Daud, Carolyn Lai, Sébastien Belliveau, Morgan S. Gold, Yao Zhang, Ishita Aggarwal, Ioana Fugaru, Pedram Akbari, Ajay Shah, Abigail White, Apoorva Bhandari, David Fleiszer, Ève Sédillot-Daniel, Florence Bénard, Florence Pelletier, Chelsea Harris, Mithusa Sivanathan, Dario Ferri, Jenny W. Jing, Sofia Valanci Aroesty, Lydia Goff, Helena Greene, Alexandra Munn, Andrew Furey, Nicholas Smith, Rhonda St. Croix, Susan Moffatt-Bruce, Guylaine Lefebvre, Edward J. Harvey, Rudolph Reindl, Hamid Al Badi, Gregory K. Berry, Paul A. Martineau, Robert Koucheki, Johnathan R. Lex, Alexandra Morozova, Tyler M. Hauer, Sarah Mirzaie, Peter C. Ferguson, Barbara Ballyk, Luz Yanguez Franco, Ian R. Drennan, Dale Button, Adam Dubrowski, Casey Thorburn, Claire Skanes, Robert Kennedy, Chris Smith, Andrei Torres, Léamarie Meloche-Dumas, Natasha Guérard-Poirier, Ahmad Kaviani, Bill Kapralos, Frédéric Mercier, Erica Patocskai, Merieme Habti, Simon Bérubé, Dominic Cadoret, Artur Arutiunian, Yasmina Papas, Antoine Melkane, Carlos Chiesa, Nicolas Fakhry, Vyvy Young, Libby Smith, Jerome Lechien, Louis Guertin, Marie-Jo Olivier, Anastasios Maniakas, R. Jun Lin, Éric Bissada, Apostolos Christopoulos, Tareck Ayad, Andrée-Anne Leclerc, Nancy Posel, Alicia Rosenzveig, Peter Gariscsak, Laryssa Kemp, Faizal Haji, Andrew Reid, Surita Sidhu, Michael Moon, Simon Turner, Bin Zheng, Jesse Isaac Wolfstadt, Jeremy Hall, Sarah Ward, Abdulrahman Jad, Nicholas Yee, Tayler Declan Ross, Peter Ferguson, Chantal Valiquette, Shakira Brathwaite, Greg Hawley, Glykeria Martou, Michael Hendry, Victoria Schouela, Mélanie Aubé-Peterkin, Andrea Winthrop, Morgan Gold, Justin T. Lui, Madeleine de Lotbiniere-Bassett, Joseph M. Chen, Vincent Y. Lin, Sumit K. Agrawal, Nikolas H. Blevins, Hanif M. Ladak, Farhad Pirouzmand, Tyler Hauer, Jesse Wolfstadt, Abdulrahman Almansouri, Mohammadreza Eskandari, Chinyelum Agu, Puja Pachchigar, Bianca Giglio, Neevya Balasubramniam, Houssem-Eddine Gueziri, Rolando Del Maestro, Tyler McKechnie, Amin Hatamnejad, Jenny Chan, Anne Beattie, Ahmad Alsayegh, Mohamad Bakhaidar, Rolando F. Del Maestro, Nafisa Dharamsi, Ingrid de Vries, Steve Mann, Laura McEwen, Timothy Phillips, Boris Zevin, Andrew Robart, Hannah Brennan, Joshua Conway, Christopher Patey, Jason Harley, Dan Poenaru, Krystina Clarke, Marie-Ève Roy, Stephane Bedwani, Érica Patocskai, Jane Zhu, Alexander Adibfar, Laura Snell, Rahul Nayak, Richard Malthaner, Dalilah Fortin, Richard Inculet, Mehdi Qiabi, Sayed Azher, Matthew Moreno, Lucia Patino Melo, Reinhard Pekrun, Jeffrey Wiseman, Gerald M. Fried, Susanne Lajoie, Ryan Brydges, Allyson Hadwin, Ning-Zi Sun, Elene Khalil, Jason M. Harley, Sarah Almas, Joanna Ryan, Blaire Anderson, Bilal Tarabay, Lucy Lan, Randi Mao, Jeffrey Kay, SA Darren de, Geoffrey Blair, Alborz Noorani, Sama Noorani, Megan Mak, George Ibrahim, Mojgan Hodaie, Katie van Kampen, Emily Domerchie, Patricia Farrugia, Maxine Joly-Chevrier, Anne Xuan-Lan Nguyen, Daiana Roxana Pur, Rebecca J. Power, Sanjay Sharma, Fiona Costello, Femida Kherani

Publikováno v: Canadian Journal of Surgery. 65:S19-S32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a838ed2732497443527cbb435ff6fc81
https://doi.org/10.1503/cjs.014622