Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Peter C E, Moody"'
Autor:
Neil Bate, Christos G Savva, Peter C E Moody, Edward A Brown, Sian E Evans, Jonathan K Ball, John W R Schwabe, Julian E Sale, Nicholas P J Brindle
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010733 (2022)
Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in develop
Externí odkaz:
https://doaj.org/article/1c450b5c20754a42910056edeab3abf1
Autor:
Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey, Emma Raven
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates
Externí odkaz:
https://doaj.org/article/443ba616a4bf488fa3708f48abac1594
Autor:
Hanna Kwon, Jaswir Basran, Cecilia M. Casadei, Alistair J. Fielding, Tobias E. Schrader, Andreas Ostermann, Juliette M. Devos, Pierre Aller, Matthew P. Blakeley, Peter C. E. Moody, Emma L. Raven
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to direct
Externí odkaz:
https://doaj.org/article/ba0cf1877308498b991c38c8062c0431
Autor:
Prof.Dr. Peter C. E. Moody, Adnan Ayna
Publikováno v:
Biochemistry and Cell Biology. 98:518-524
The glycolytic pathway of the enteric pathogen Campylobacter jejuni is incomplete; the absence of phosphofructokinase means that the suppression of futile cycling at this point in the glycolytic–gluconeogenic pathway might not be required, and ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7434adbc8f75f9900746ce471ce0154a
https://doi.org/10.1139/bcb-2020-0021
https://doi.org/10.1139/bcb-2020-0021
Autor:
Sofia M. Kapetanaki, Mark J. Burton, Jaswir Basran, Chiasa Uragami, Peter C. E. Moody, John S. Mitcheson, Ralf Schmid, Noel W. Davies, Pierre Dorlet, Marten H. Vos, Nina M. Storey, Emma Raven
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this article contained an error in the subheading ‘Heme is required for CO-dependent channel activation’, which was incorrectly given as ‘Hame is required for CO-dependent channel activation’. This has now
Externí odkaz:
https://doaj.org/article/112dfef6f2674e25b9fc4f30441b3d46
Autor:
Mehul H. Jesani, Jonathan Clayden, Laura P. Campbell, Sarah J. Thackray, Jaswir Basran, Peter C. E. Moody, Emma Lloyd Raven, Elizabeth S. Booth, Christopher G. Mowat, Hanna Kwon
Publikováno v:
Basran, J, Booth, E S, Campbell, L P, Thackray, S J, Jesani, M H, Clayden, J, Moody, P C E, Mowat, C G, Kwon, H & Raven, E L 2021, ' Binding of L-kynurenine to X. campestris tryptophan 2,3-dioxygenase ', Journal of Inorganic Biochemistry, vol. 225, 111604 . https://doi.org/10.1016/j.jinorgbio.2021.111604
The kynurenine pathway is the major route of tryptophan metabolism. The first step of this pathway is catalysed by one of two heme-dependent dioxygenase enzymes – tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) – leading in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9ed062898cb8f82251351b97a81a35
https://pubmed.ncbi.nlm.nih.gov/34571402
https://pubmed.ncbi.nlm.nih.gov/34571402
Autor:
Umakhanth Venkatraman Girija, Emma Lloyd Raven, Alistair J. Fielding, Louise Fairall, Dimitri A. Svistunenko, Samuel L. Freeman, Charalambos P. Kyriacou, Gary Parkin, Nicola Portolano, Peter C. E. Moody, Hanna Kwon, Jaswir Basran, John W.R. Schwabe
Publikováno v:
Freeman, S L, Kwon, H, Portolano, N, Parkin, G, Girija, U V, Basran, J, Fielding, A J, Fairall, L, Svistuneko, D A, Moody, P C E, Schwabe, J W R, Kyriacou, C P & Raven, E 2019, ' Heme binding to human CLOCK affects interactions with the E-box ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 40, pp. 19911-19916 . https://doi.org/10.1073/pnas.1905216116
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. The circadian clock is an endogenous time-keeping system that is ubiquitous in animals and plants as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a24f39680f6f48b410fef70ef5d4af8
https://doi.org/10.1073/pnas.1905216116
https://doi.org/10.1073/pnas.1905216116
Autor:
Tobias E. Schrader, Reynier Suardíaz, Marc W. van der Kamp, Matthew P. Blakeley, Andreas Ostermann, Jaswir Basran, Hanna Kwon, Adrian J. Mulholland, Juliette M. Devos, Emma Lloyd Raven, Peter C. E. Moody
Publikováno v:
Kwon, H, Basran, J, Devos, J M, Suardiaz Del Rio, R, Van Der Kamp, M W, Mulholland, A J, Schrader, T E, Ostermann, A, Blakeley, M P, Moody, P C E & Raven, E 2020, ' Visualizing the protons in a metalloenzyme electron proton transfer pathway ', Proceedings of the National Academy of Sciences of the United States of America . https://doi.org/10.1073/pnas.1918936117
Proceedings of the National Academy of Sciences of the United States of America 117(12), 6484-6490 (2020). doi:10.1073/pnas.1918936117
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America 117(12), 6484-6490 (2020). doi:10.1073/pnas.1918936117
Proc Natl Acad Sci U S A
In redox metalloenzymes, the process of electron transfer often involves the concerted movement of a proton. These processes are referred to as proton-coupled electron transfer, and they underpin a wide variety of biological processes, including resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5d0c60b8dad118e90a1a4953bb4391
https://research-information.bris.ac.uk/en/publications/1fb08f30-b3f4-4c9c-8b9c-70b658dc8784
https://research-information.bris.ac.uk/en/publications/1fb08f30-b3f4-4c9c-8b9c-70b658dc8784
Autor:
Adnan, Ayna, Peter C E, Moody
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 98(4)
The glycolytic pathway of the enteric pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd65d2aeebd77b089b5cb1ba6dd1f5c1
https://pubmed.ncbi.nlm.nih.gov/32125881
https://pubmed.ncbi.nlm.nih.gov/32125881
Autor:
Hanna, Kwon, Tobias E, Schrader, Andreas, Ostermann, Matthew P, Blakeley, Emma L, Raven, Peter C E, Moody
Publikováno v:
Methods in enzymology 634, 379-389 (2020). doi:10.1016/bs.mie.2020.01.010
By combining the normal practice for X-ray crystallography of collecting diffraction data at 100K with neutron crystallography the structures of cryo-trapped enzyme intermediates have been determined, revealing the positions of the previously hidden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::235d6c3b5faa97c58464b95faa734c5e
https://hdl.handle.net/2128/30474
https://hdl.handle.net/2128/30474