Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Autor: Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart I Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska

Publikováno v: Clinical & Translational Immunology, Vol 8, Iss 9, Pp n/a-n/a (2019)

Abstract Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T

Externí odkaz: https://doaj.org/article/7ff1b72faa64454082fb640c16d1ffe8

Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice.

Autor: Susu Duan, Victoria A Meliopoulos, Jennifer L McClaren, Xi-Zhi J Guo, Catherine J Sanders, Heather S Smallwood, Richard J Webby, Stacey L Schultz-Cherry, Peter C Doherty, Paul G Thomas

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004642 (2015)

The recent emergence of a novel H7N9 influenza A virus (IAV) causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential prote

Externí odkaz: https://doaj.org/article/5588ffd71821403d9c3f2a7168f990b7

Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function.

Autor: Sophie A Valkenburg, Vanessa Venturi, Thurston H Y Dang, Nicola L Bird, Peter C Doherty, Stephen J Turner, Miles P Davenport, Katherine Kedzierska

Publikováno v: PLoS Pathogens, Vol 8, Iss 2, p e1002544 (2012)

The elderly are particularly susceptible to influenza A virus infections, with increased occurrence, disease severity and reduced vaccine efficacy attributed to declining immunity. Experimentally, the age-dependent decline in influenza-specific CD8(+

Externí odkaz: https://doaj.org/article/6fa5a2ce4ae94b5194f76687d579ccd1

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.

Autor: Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

Publikováno v: PLoS Pathogens, Vol 6, Iss 8, p e1001039 (2010)

Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8(+) T-cell immunity directed towards conserved internal viral regions can greatly ameliorate the disease. However, mutat

Externí odkaz: https://doaj.org/article/7fe5fc283dff490dac8634d0cb6d116a

Suboptimal SARS-CoV-2−specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype

Autor: Xiaoxiao Jia, Jan Petersen, Allen C. Cheng, Joseph Torresi, Adam K. Wheatley, Brendon Y. Chua, Priyanka Chaurasia, Peter C. Doherty, Carolien E. van de Sandt, Jamie Rossjohn, Hyon-Xhi Tan, Denise L. Doolan, Wuji Zhang, Thi H. O. Nguyen, Stephen J. Kent, Linda M. Wakim, Jennifer R. Habel, Luca Hensen, Jennifer A Juno, Katherine Kedzierska, Weisan Chen, Katie L. Flanagan, Marios Koutsakos, Kathleen M. Wragg, Louise C. Rowntree

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24384-24391. National Academy of Sciences

Significance As the recall of CD8+ T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific CD8+ T cells from COVID-19 patients. For two HLA-A*02:01 SARS-CoV-2−specific CD8+ T cell epitopes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77556aaf62fc1f108a7d19e93311e1be
http://www.scopus.com/inward/record.url?scp=85092314009&partnerID=8YFLogxK