Small hydrophobic protein of human metapneumovirus does not affect virus replication and host gene expression in vitro.

Autor: Miranda de Graaf, Sander Herfst, Jamil Aarbiou, Peter C Burgers, Fatiha Zaaraoui-Boutahar, Maarten Bijl, Wilfred van Ijcken, Eefje J A Schrauwen, Albert D M E Osterhaus, Theo M Luider, Bob J Scholte, Ron A M Fouchier, Arno C Andeweg

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58572 (2013)

Human metapneumovirus (HMPV) encodes a small hydrophobic (SH) protein of unknown function. HMPV from which the SH open reading frame was deleted (HMPVΔSH) was viable and displayed similar replication kinetics, cytopathic effect and plaque size compa

Externí odkaz: https://doaj.org/article/228aa1f0d2004a7998ff55e0cca15a17

Ultra-fast analysis of plasma and intracellular levels of HIV protease inhibitors in children: a clinical application of MALDI mass spectrometry.

Autor: Jeroen J A van Kampen, Mariska L Reedijk, Peter C Burgers, Lennard J M Dekker, Nico G Hartwig, Ineke E van der Ende, Ronald de Groot, Albert D M E Osterhaus, David M Burger, Theo M Luider, Rob A Gruters

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11409 (2010)

HIV protease inhibitors must penetrate into cells to exert their action. Differences in the intracellular pharmacokinetics of these drugs may explain why some patients fail on therapy or suffer from drug toxicity. Yet, there is no information availab

Externí odkaz: https://doaj.org/article/754670a0851940d0a990a4d05dd52f35

Increased Targeting Area in Tumors by Dual-Ligand Modification of Liposomes with RGD and TAT Peptides

Autor: Mohamadreza Amin, Mercedeh Mansourian, Peter C. Burgers, Bahareh Amin, Mahmoud Reza Jaafari, Timo L. M. ten Hagen

Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 458 (2022)

Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids drastically improve the pharmacokinetics of chemotherapeutics and result in more manageable or reduced side-effects. A major drawback is retarded cellular delivery

Externí odkaz: https://doaj.org/article/4d044e333bf048089e669b815cab6e20

Data Processing Pipeline for Lipid Profiling of Carotid Atherosclerotic Plaque with Mass Spectrometry Imaging

Autor: Kim Van der Heiden, Antonius Fw van der Steen, Hence J.M. Verhagen, Heleen M.M. van Beusekom, Peter C. Burgers, Mirjam Visscher, Theo M. Luider, Gijs van Soest, Astrid M. Moerman

Publikováno v: Journal of the American Society for Mass Spectrometry, 30(9), 1790-1800. American Chemical Society
Journal of the American Society for Mass Spectrometry

Atherosclerosis is a lipid and inflammation-driven disease of the arteries that is characterized by gradual buildup of plaques in the vascular wall. A so-called vulnerable plaque, consisting of a lipid-rich necrotic core contained by a thin fibrous c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40feeeb8b344a5ac1cd0575c331d345
https://doi.org/10.1007/s13361-019-02254-y

Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging

Autor: Antonius Fw van der Steen, Hence J.M. Verhagen, Mirjam Visscher, Nuria Slijkhuis, Peter C. Burgers, Heleen M.M. van Beusekom, Theo Klein, Astrid M. Moerman, Kim Van der Heiden, Yolanda B. de Rijke, Kim van Gaalen, Gijs van Soest, Bram Heijs, Theo M. Luider, Frank J. H. Gijsen

Publikováno v: Journal of Lipid Research, Vol 62, Iss, Pp 100020-(2021)
Journal of Lipid Research
Journal of Lipid Research, 62. ELSEVIER
Journal of Lipid Research, 62:100020. American Society for Biochemistry and Molecular Biology Inc.

Carotid atherosclerosis is a risk factor for ischemic stroke, one of the main causes of mortality and disability worldwide. The disease is characterized by plaques, heterogeneous deposits of lipids, and necrotic debris in the vascular wall, which gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d440cac86ce846438ba8fc6a1578790
https://hdl.handle.net/1887/3246770