Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Peter C Breen"'
Publikováno v:
eLife, Vol 12 (2024)
Dedicated genetic pathways regulate cysteine homeostasis. For example, high levels of cysteine activate cysteine dioxygenase, a key enzyme in cysteine catabolism in most animal and many fungal species. The mechanism by which cysteine dioxygenase is r
Externí odkaz:
https://doaj.org/article/6521f18b186b4c8e80f049fca95ac413
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002320 (2023)
Animals integrate developmental and nutritional signals before committing crucial resources to growth and reproduction; however, the pathways that perceive and respond to these inputs remain poorly understood. Here, we demonstrate that DRL-1 and FLR-
Externí odkaz:
https://doaj.org/article/3e59e8235eb4443d89f2901dde7fcf9e
Autor:
Sylvia E J Fischer, Taiowa A Montgomery, Chi Zhang, Noah Fahlgren, Peter C Breen, Alexia Hwang, Christopher M Sullivan, James C Carrington, Gary Ruvkun
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002369 (2011)
Endogenous small interfering RNAs (siRNAs) are a class of naturally occuring regulatory RNAs found in fungi, plants, and animals. Some endogenous siRNAs are required to silence transposons or function in chromosome segregation; however, the specific
Externí odkaz:
https://doaj.org/article/51e9ea26caa74dd09c4adc58ba7a5093
Publikováno v:
bioRxiv
The amino acid cysteine is critical for many aspects of life, yet excess cysteine is toxic. Therefore, animals require pathways to maintain cysteine homeostasis. In mammals, high cysteine activates cysteine dioxygenase, a key enzyme in cysteine catab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82986985987b382191ec650192d46521
https://doi.org/10.1101/2023.05.04.538701
https://doi.org/10.1101/2023.05.04.538701
Animals integrate developmental and nutritional signals before committing crucial resources to growth and reproduction; however, the pathways that perceive and respond to these inputs remain poorly understood. Here, we demonstrate that DRL-1 and FLR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::216fb1c34e1ace64bec669927f70cd83
https://doi.org/10.1101/2023.01.07.523122
https://doi.org/10.1101/2023.01.07.523122
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3000996 (2020)
PLoS Biology
PLoS Biology
RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids. In mammals, mitochondrially localized proteins such as mitochondrial antiviral signaling (MAVS), retinoic acid-inducible gene I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4981aafc3603b8b15b8e045321b001
https://doaj.org/article/1c7f9dc4bcfa46639ce33b45c9388f14
https://doaj.org/article/1c7f9dc4bcfa46639ce33b45c9388f14
Publikováno v:
Cell. 177(3)
The proteasome mediates selective protein degradation and is dynamically regulated in response to proteotoxic challenges. SKN-1A/Nrf1, an endoplasmic reticulum (ER)-associated transcription factor that undergoes N-linked glycosylation, serves as a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337285a009f87be99ea91548f93060cb
https://pubmed.ncbi.nlm.nih.gov/31053827
https://pubmed.ncbi.nlm.nih.gov/31053827
Autor:
Peter C. Breen, J. Amaranath Govindan, Eleftherios Mylonakis, Jonah Larkins-Ford, Gary Ruvkun, Elamparithi Jayamani, Xinrui Zhang
Publikováno v:
Nature cell biology
Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c715dfe31db8035ccd55e3189ffdcc3f
https://doi.org/10.1038/ncb3229
https://doi.org/10.1038/ncb3229
Publikováno v:
Nature. 508:406-410
A genome-wide RNA interference screen in Caenorhabditis elegans identifies 45 genes with roles in protective pathways following drug- and genetic-disruption-induced mitochondrial inhibition. Damage to mitochondria, the cellular organelles that genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb88e09c26f77a31ef30c0534a0ec1
https://doi.org/10.1038/nature13204
https://doi.org/10.1038/nature13204
Autor:
Josien C. van Wolfswinkel, Peter C. Breen, Martin A. Newman, Brooke E Montgomery, Elke F. Roovers, René F. Ketting, Toshiro K. Ohsumi, Young-Soo Rim, Carolyn M. Phillips, Gary Ruvkun, Taiowa A. Montgomery
Publikováno v:
Current Biology
Summary More than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized small interfering RNA (siRNA) amplification module which is nucleated by the Q/N-rich protein MUT-16. The mutator complex localizes to Mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66138937a6bbcb3ccc776bc5acd60d6e