Zobrazeno 1 - 10
of 422
pro vyhledávání: '"Peter C, Searson"'
Autor:
Nan Zhao, Tracy D. Chung, Zhaobin Guo, John J. Jamieson, Lily Liang, Raleigh M. Linville, Alex F. Pessell, Linus Wang, Peter C. Searson
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/3036017516904da3805339a2d9ff5d28
Autor:
Raleigh M. Linville, Joanna Maressa, Zhaobin Guo, Tracy D. Chung, Alanna Farrell, Ria Jha, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Metastatic brain cancer has poor prognosis due to challenges in both detection and treatment. One contributor to poor prognosis is the blood–brain barrier (BBB), which severely limits the transport of therapeutic agents to intracranial tum
Externí odkaz:
https://doaj.org/article/b6b3ad3020354fc4924da38fda05a686
Autor:
Nan Zhao, Tracy D. Chung, Zhaobin Guo, John J. Jamieson, Lily Liang, Raleigh M. Linville, Alex F. Pessell, Linus Wang, Peter C. Searson
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The blood-brain barrier (BBB) is located at the interface between the vascular system and the brain parenchyma, and is responsible for communication with systemic circulation and peripheral tissues. During life, the BBB can be subjected to a wide ran
Externí odkaz:
https://doaj.org/article/7729807786624016b9f49d5ffcd572db
Autor:
Zheng Xu, Nicole Zahradka, Seyvonne Ip, Amir Koneshloo, Ryan T. Roemmich, Sameep Sehgal, Kristin B. Highland, Peter C. Searson
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-11 (2022)
Abstract Physical health status defines an individual’s ability to perform normal activities of daily living and is usually assessed in clinical settings by questionnaires and/or by validated tests, e.g. timed walk tests. These measurements have re
Externí odkaz:
https://doaj.org/article/9262049a2bdc4d8695f15830e9cc2e0f
Autor:
Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renée F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport, and express specialized trans
Externí odkaz:
https://doaj.org/article/15afde94b0a94a09910c567e9da7cd9c
Autor:
Raleigh M. Linville, Renée F. Nerenberg, Gabrielle Grifno, Diego Arevalo, Zhaobin Guo, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Huntington’s disease (HD) is an inherited neurodegenerative disease caused by expansion of cytosine–adenine–guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss and decline in cognitive and motor function. Increas
Externí odkaz:
https://doaj.org/article/85acde5431e54ce2a92f01e6c9bc0479
Autor:
Tracy D. Chung, Raleigh M. Linville, Zhaobin Guo, Robert Ye, Ria Jha, Gabrielle N. Grifno, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Oxidative stress is a shared pathology of neurodegenerative disease and brain injuries, and is derived from perturbations to normal cell processes by aging or environmental factors such as UV exposure and air pollution. As oxidative cues are
Externí odkaz:
https://doaj.org/article/ddf88ade450a4032ae76063b50f137d8
Autor:
Raleigh M. Linville, Peter C. Searson
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-7 (2021)
Abstract With the limitations associated with post-mortem tissue and animal models, In vitro BBB models enable precise control of independent variables and microenvironmental cues, and hence play an important role in studying the BBB. Advances in ste
Externí odkaz:
https://doaj.org/article/34dcace3fc3a4f12bc368a88dc041b40
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1100-1112 (2021)
Externí odkaz:
https://doaj.org/article/8e92cc16e1d54f4c9a7d884ffd66678c
Autor:
Zhaobin Guo, Nan Zhao, Tracy D. Chung, Anjan Singh, Ikshu Pandey, Linus Wang, Xinyue Gu, Aisha Ademola, Raleigh M. Linville, Utpal Pal, J. Stephen Dumler, Peter C. Searson
Publikováno v:
Advanced Science, Vol 9, Iss 35, Pp n/a-n/a (2022)
Abstract Lyme disease is a tick‐borne disease prevalent in North America, Europe, and Asia. Despite the accumulated knowledge from epidemiological, in vitro, and in animal studies, the understanding of dissemination of vector‐borne pathogens, suc
Externí odkaz:
https://doaj.org/article/8b58abd72416402cbf9484cb6dd46537