Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Peter C, Ray"'
Autor:
Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis
Externí odkaz:
https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e
Autor:
Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
Publikováno v:
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
Externí odkaz:
https://doaj.org/article/0a27546e2eeb4807bfe33c85491f6518
Autor:
Clifton E. Barry, Paul G. Wyatt, Yoshitaka Tateishi, Andaleeb Sajid, M. Daben J. Libardo, Sangmi Oh, Caroline J. Duncombe, Peter C. Ray, David W. Gray, Gary T. Pauly, Jose Santinni O Roma, Thomas R. Ioerger, Helena I. Boshoff, Shaik Azeeza, Michael Goodwin
Publikováno v:
ACS Infectious Diseases. 7:479-492
Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b286eaa3ebb59880cbd57cff884986
https://doi.org/10.1021/acsinfecdis.0c00851
https://doi.org/10.1021/acsinfecdis.0c00851
Autor:
Tanya Parish, Lindsay Flint, Anuradha Kumar, Lisa M. Massoudi, Paul Scullion, Gregory T. Robertson, Shilah A. Bonnett, Simon Green, Nicola Caldwell, Jennifer Riley, Gail M. Freiberg, Philip Arthur Hipskind, Michael Mathieson, Thierry Masquelin, Laste Stojanovski, Curtis A. Engelhart, Margaret Huggett, Dinakaran Murugesan, Abraham Lopez Moure, Fabio Zuccotto, Julie V. Early, Ola Epemolu, Paul G. Wyatt, Dale J. Kempf, Kevin D. Read, Susan Davis, Laura A. T. Cleghorn, James Johnson, Steven Mullen, Malcolm Taylor, Anne J. Lenaerts, Penelope A. Turner, Peter C. Ray, Joshua Odingo, Dirk Schnappinger, Aaron Korkegian, Douglas Joerss
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action. A number of scaffolds with potent anti-tubercular in vitro activity have been identified fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372e1778402b9efb43904bc638481606
http://europepmc.org/articles/PMC7841955
http://europepmc.org/articles/PMC7841955
Autor:
Paul G. Wyatt, Peter C. Ray, Kyu Y. Rhee, Sasha L. Lynch, Valerie Mizrahi, Clifton E. Barry, John Post, Helena I. Boshoff, Navid Nahiyaan, Anthony G. Coyne, Tom L. Blundell, Joanna C. Evans, Christina Spry, Dinakaran Murugesan, Vitor Mendes, Simon Green, Jeannine Hess, Stephen Thompson, Chris Abell, Zhe Wang
Publikováno v:
ACS Infectious Diseases
Coenzyme A (CoA) is a ubiquitous cofactor present in all living cells and estimated to be required for up to 9% of intracellular enzymatic reactions. Mycobacterium tuberculosis (Mtb) relies on its own ability to biosynthesize CoA to meet the needs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b118e20c165cc2ee3aa60e19f743440
https://www.repository.cam.ac.uk/handle/1810/322238
https://www.repository.cam.ac.uk/handle/1810/322238
Autor:
Sangmi, Oh, M Daben J, Libardo, Shaik, Azeeza, Gary T, Pauly, Jose Santinni O, Roma, Andaleeb, Sajid, Yoshitaka, Tateishi, Caroline, Duncombe, Michael, Goodwin, Thomas R, Ioerger, Paul G, Wyatt, Peter C, Ray, David W, Gray, Helena I M, Boshoff, Clifton E, Barry
Publikováno v:
ACS Infectious Diseases
Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2eb5f816040cc19e46ca7fcd8417fa0
https://pubmed.ncbi.nlm.nih.gov/33405882
https://pubmed.ncbi.nlm.nih.gov/33405882
Autor:
Kirsteen I. Buchanan, Clifton E. Barry, Simon Green, Gregory S. Basarab, Qin Su, Charles J. Eyermann, Curtis A. Engelhart, Anuradha Kumar, Paul D. van Helden, Frederick A. Sirgel, Paul G. Wyatt, Nina Lawrence, Sandeep R. Ghorpade, Dirk Schnappinger, Dale Taylor, Sandile B. Simelane, Helena I. Boshoff, Christel Brunschwig, Vinayak Singh, Kelly Chibale, Peter C. Ray, Tracy Bayliss, Candice Soares de Melo, Alissa Myrick, Tanya Parish, Timothy G. Myers
Publikováno v:
Journal of Medicinal Chemistry
Phenotypic screening of a Medicines for Malaria Venture compound library against Mycobacterium tuberculosis (Mtb) identified a cluster of pan-active 2-pyrazolylpyrimidinones. The biology triage of these actives using various tool strains of Mtb sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5eafa1e33ac7c64b2164da5d55d9f9
https://pubmed.ncbi.nlm.nih.gov/33395287
https://pubmed.ncbi.nlm.nih.gov/33395287
Autor:
Clifton E. Barry, Paul G. Wyatt, Sasha L. Lynch, Pedro Henrique Monteiro Torres, Daniel Shiu-Hin Chan, Simon Green, Helena I. Boshoff, Joanna C. Evans, Vitor Mendes, Kyu Y. Rhee, James Cory-Wright, Michal Blaszczyk, Peter C. Ray, Valerie Mizrahi, Sebastian Damerow, Navid Nahiyaan, Anthony G. Coyne, John Post, Tom L. Blundell, Tracy Bayliss, Sandra O’Neill, Chris Abell, Jeannine Hess, Christina Spry, Zhe Wang, Owain J. Bryant
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens including Mycobacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93480516255c2e8d7aeba39be349059
http://europepmc.org/articles/PMC7794376
http://europepmc.org/articles/PMC7794376
Autor:
Michael Goodwin, Caroline J. Duncombe, Peter C. Ray, Helena I. Boshoff, M. Daben J. Libardo, Clifton E. Barry, Simon Green, Stephen Thompson, Sangmi Oh, Thomas R. Ioerger, Paul G. Wyatt
Publikováno v:
SSRN Electronic Journal.
Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs. We identified a series of indole-4-carboxamides with potent antitubercular activity. In vitro, Mycobacterium tuberculosis (Mtb) acquired resistance to these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac13c454eb02465daf65139556928820
https://doi.org/10.2139/ssrn.3724670
https://doi.org/10.2139/ssrn.3724670
Autor:
Zhe Wang, Valerie Mizrahi, Christina Spry, Kyu Y. Rhee, Sebastian Damerow, John Post, Owain J. Bryant, James Cory-Wright, Sasha L. Lynch, Sandra O’Neill, Tracy Bayliss, Michal Blaszczyk, Paul G. Wyatt, Clifton E. Barry, Pedro Henrique Monteiro Torres, Jeannine Hess, Peter C. Ray, Vitor Mendes, Tom L. Blundell, Simon Green, Chris Abell, Joanna C. Evans, Helena I. Boshoff, Daniel S-H. Chan, Anthony G. Coyne
Coenzyme A (CoA) is a fundamental co-factor for all life, involved in numerous metabolic pathways and cellular processes, and its biosynthetic pathway has raised substantial interest as a drug target against multiple pathogens includingMycobacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad01cb6cb3beb75dc60f063a9f3eaf83