Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Peter C, Knipe"'
Autor:
Ailbhe A. Ryan, Seán D. Dempsey, Megan Smyth, Karen Fahey, Thomas S. Moody, Scott Wharry, Paul Dingwall, David W. Rooney, Jillian M. Thompson, Peter C. Knipe, Mark J. Muldoon
Publikováno v:
Ryan, A A, Dempsey, S D, Smyth, M, Fahey, K, Moody, T S, Wharry, S, Dingwall, P, Rooney, D W, Thompson, J M, Knipe, P C & Muldoon, M J 2023, ' Continuous flow epoxidation of alkenes using a homogeneous manganese catalyst with peracetic acid ', Organic Process Research & Development, vol. 27, no. 2, pp. 262-268 . https://doi.org/10.1021/acs.oprd.2c00222
Epoxidation of alkenes is a valuable transformation in the synthesis of fine chemicals. Described herein are the design and development of a continuous flow process for carrying out the epoxidation of alkenes with a homogeneous manganese catalyst at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135dec43fe75733e0ac2ff5f7dbc60df
https://pure.qub.ac.uk/en/publications/82f5fd9a-614d-4bcd-8bfe-8207570b3686
https://pure.qub.ac.uk/en/publications/82f5fd9a-614d-4bcd-8bfe-8207570b3686
Autor:
Peter C. Knipe, Jamie S. Sweet
Publikováno v:
Sweet, J S & Knipe, P C 2022, ' Catalytic enantioselective synthesis of C–N atropisomeric heterobiaryls ', Synthesis, vol. 54 . https://doi.org/10.1055/s-0040-171989
Molecules containing an atropisomeric C–N biaryl axis are gaining increasing attention in catalytic and medicinal chemistry. Despite this rising interest, relatively few approaches towards their catalytic enantioselective synthesis have been report
Publikováno v:
Molecules, Vol 19, Iss 8, Pp 11316-11332 (2014)
Herein we describe the design and synthesis of a redox-dependent single-molecule switch. Appending a ferrocene unit to a diphenylacetylene scaffold gives a redox-sensitive handle, which undergoes reversible one-electron oxidation, as demonstrated by
Externí odkaz:
https://doaj.org/article/848dcffc5a534ed78552bb2299b7f17b
Publikováno v:
Duffy, C, Roe, W E, Harkin, A M, McNamee, R & Knipe, P C 2021, ' Enantioselective organocatalytic formal [3+2]-cycloaddition of isatin-derived ketimines with benzylidenemalononitriles and benzylidineindanones ', New Journal of Chemistry . https://doi.org/10.1039/D1NJ04002B
The biological and medicinal importance of oxindole-derived spirocycles is now well-established, and has inspired the development of numerous creative synthetic strategies. Here we report an efficient formal [3+2]-cycloaddition of isatin-derived N-tr
Autor:
Clementine E. Bavinton, Rebecca Sternke-Hoffmann, Tohru Yamashita, Peter C. Knipe, Andrew D. Hamilton, Jinghui Luo, Sam Thompson
Publikováno v:
Bavinton, C E, Sternke-Hoffmann, R, Yamashita, T, Knipe, P C, Hamilton, A D, Luo, J & Thompson, S 2022, ' Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation ', Chemical Communications, vol. 58, no. 33, pp. 5132-5135 . https://doi.org/10.1039/d2cc00212d
Misfolding of the human protein α-synuclein results in toxic fibrils and the aggregation of Lewy bodies, which are a hallmark of Parkinson's disease in brain tissue. Here we disclose a supramolecular approach where peptidomimetics are rationally des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bd62d74854a2b02770c7820f6ee235
https://eprints.soton.ac.uk/456397/
https://eprints.soton.ac.uk/456397/
Publikováno v:
Sweet, J S, Wang, R, Manesiotis, P, Dingwall, P & Knipe, P C 2022, ' Atropselective synthesis of N-aryl pyridones via dynamic kinetic resolution enabled by non-covalent interactions ', Organic and Biomolecular Chemistry, vol. 20, no. 12, pp. 2392-2396 . https://doi.org/10.1039/d2ob00177b
The dynamic kinetic resolution of C–N atropisomeric pyridones was achieved via asymmetric phase-transfer catalysis, exploiting a rotational barrier-lowering hydrogen bond in the starting materials. X-ray and NMR experiments revealed the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3265550593fea77239d39167724bc3
https://pure.qub.ac.uk/en/publications/251b012d-7035-42bd-96dc-d233abe12999
https://pure.qub.ac.uk/en/publications/251b012d-7035-42bd-96dc-d233abe12999
Publikováno v:
Organicbiomolecular chemistry. 20(12)
The dynamic kinetic resolution of C-N atropisomeric pyridones was achieved
Autor:
Matthew Fitzpatrick, Sundaram Rajkumar, Paul Dingwall, Toyah M. C. Warnock, Peter C. Knipe, Christopher J. Serpell
Publikováno v:
Warnock, T M C, Sundaram, R, Fitzpatrick, M P, Serpell, C J, Dingwall, P & Knipe, P C 2021, ' Chiral, Sequence-Definable Foldamer-Derived Macrocycles ', Chemical Science, vol. 12, no. 47, pp. 15632-15636 . https://doi.org/10.1039/D1SC05021D
Chemical Science
Chemical Science
Nature's oligomeric macromolecules have been a long-standing source of inspiration for chemists producing foldamers. Natural systems are frequently conformationally stabilised by macrocyclisation, yet this approach has been rarely adopted in the fiel
Publikováno v:
Sweet, J S, Rajkumar, S, Dingwall, P & Knipe, P C 2021, ' Atroposelective Synthesis, Structure and Properties of a Novel Class of Axially Chiral N-Aryl Quinolinium Salt ', European Journal of Organic Chemistry, vol. 2021, no. 29, pp. 3980-3985 . https://doi.org/10.1002/ejoc.202100188
Inspired by naturally occurring molecules containing atropisomeric N + ‐C axes, we have developed a novel synthetic approach to generate a library of axially chiral N ‐aryl quinolinium salts. Enantiopurities up to 93% ee were obtained via a four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5facdf2991fd101858dccf3b33c55089
https://pure.qub.ac.uk/en/publications/atroposelective-synthesis-structure-and-properties-of-a-novel-class-of-axially-chiral-naryl-quinolinium-salt(6f8e1151-4079-4652-aafb-e050655faba1).html
https://pure.qub.ac.uk/en/publications/atroposelective-synthesis-structure-and-properties-of-a-novel-class-of-axially-chiral-naryl-quinolinium-salt(6f8e1151-4079-4652-aafb-e050655faba1).html
Autor:
Zachariah, Lockhart, Peter C, Knipe
Publikováno v:
Angewandte Chemie (International Ed. in English)
Foldamers are an important class of abiotic macromolecules, with potential therapeutic applications in the disruption of protein–protein interactions. The majority adopt a single conformational motif such as a helix. A class of foldamer is now intr