Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Peter C, Hollenhorst"'
Autor:
Ahmed H. Ghobashi, Truc T. Vuong, Jane W. Kimani, Christopher A. Ladaika, Peter C. Hollenhorst, Heather M. O’Hagan
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107630- (2023)
Summary: Colorectal cancer (CRC) develops in part through the deregulation of different signaling pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally, the lysine methyltransferase enhancer of zeste homologue 2 (EZ
Externí odkaz:
https://doaj.org/article/8c89486deec245ebab43998162055371
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009708 (2021)
The TMPRSS2/ERG gene rearrangement occurs in 50% of prostate tumors and results in expression of the transcription factor ERG, which is normally silent in prostate cells. ERG expression promotes prostate tumor formation and luminal epithelial cell fa
Externí odkaz:
https://doaj.org/article/afec4a57568441b48b49b4d306cf744d
Autor:
Taylor R Nicholas, Jingwei Meng, Benjamin M Greulich, Teresa Stevie Morris, Peter C Hollenhorst
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238999 (2020)
Aberrant expression of the transcription factor ERG is a key driving event in approximately one-half of all of prostate cancers. Lacking an enzymatic pocket and mainly disordered, the structure of ERG is difficult to exploit for therapeutic design. W
Externí odkaz:
https://doaj.org/article/769877bbe6ef46a58b453f88142399e8
Autor:
Harish Potu, Luke F. Peterson, Malathi Kandarpa, Anupama Pal, Hanshi Sun, Alison Durham, Paul W. Harms, Peter C. Hollenhorst, Ugur Eskiocak, Moshe Talpaz, Nicholas J. Donato
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts
Externí odkaz:
https://doaj.org/article/e602171c7095415dab7480a2914dff72
Autor:
Vivekananda Kedage, Nagarathinam Selvaraj, Taylor R. Nicholas, Justin A. Budka, Joshua P. Plotnik, Travis J. Jerde, Peter C. Hollenhorst
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1289-1301 (2016)
Summary: More than 50% of prostate tumors have a chromosomal rearrangement resulting in aberrant expression of an oncogenic ETS family transcription factor. However, mechanisms that differentiate the function of oncogenic ETS factors expressed in pro
Externí odkaz:
https://doaj.org/article/875f7987522647da9e3288a80e15b123
Autor:
Roberto Pili, Peter C. Hollenhorst, George M. Yousef, W. Marston Linehan, Chinghai Kao, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Remi Adelaiye-Ogala, Venkata Nithinsai Chintala, Khunsha Ahmed, Anthony C. Wood, Eric Kauffman, Sheng Yu Ku, Mary W. Ferris, Heba W.Z Khella, Justin A. Budka, Nur P. Damayanti
Animal body weights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2734b747b7d6f67bbb0a56a7ea390c41
https://doi.org/10.1158/1078-0432.22470068
https://doi.org/10.1158/1078-0432.22470068
Autor:
Roberto Pili, Peter C. Hollenhorst, George M. Yousef, W. Marston Linehan, Chinghai Kao, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Remi Adelaiye-Ogala, Venkata Nithinsai Chintala, Khunsha Ahmed, Anthony C. Wood, Eric Kauffman, Sheng Yu Ku, Mary W. Ferris, Heba W.Z Khella, Justin A. Budka, Nur P. Damayanti
Specificity of TFE3 antibody across TFE3 oncoproteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba0eca84b8983311d8f7d594e2e690b
https://doi.org/10.1158/1078-0432.22470089.v1
https://doi.org/10.1158/1078-0432.22470089.v1
Autor:
Roberto Pili, Peter C. Hollenhorst, George M. Yousef, W. Marston Linehan, Chinghai Kao, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Remi Adelaiye-Ogala, Venkata Nithinsai Chintala, Khunsha Ahmed, Anthony C. Wood, Eric Kauffman, Sheng Yu Ku, Mary W. Ferris, Heba W.Z Khella, Justin A. Budka, Nur P. Damayanti
A complete list of targeted genes in the PI3K/AKT signaling pathway with their associated miRNA from cluster 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1b7ba01f70e9e53a7bd5473c015fbf
https://doi.org/10.1158/1078-0432.22470047
https://doi.org/10.1158/1078-0432.22470047
Autor:
Roberto Pili, Peter C. Hollenhorst, George M. Yousef, W. Marston Linehan, Chinghai Kao, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Remi Adelaiye-Ogala, Venkata Nithinsai Chintala, Khunsha Ahmed, Anthony C. Wood, Eric Kauffman, Sheng Yu Ku, Mary W. Ferris, Heba W.Z Khella, Justin A. Budka, Nur P. Damayanti
Purpose:Translocation renal cell carcinoma (tRCC) represents a rare subtype of kidney cancer associated with various TFE3, TFEB, or MITF gene fusions that are not responsive to standard treatments for RCC. Therefore, the identification of new therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57aa1bbfdfdee645d00df8ebe9cbc024
https://doi.org/10.1158/1078-0432.c.6527420.v1
https://doi.org/10.1158/1078-0432.c.6527420.v1
Autor:
Roberto Pili, Peter C. Hollenhorst, George M. Yousef, W. Marston Linehan, Chinghai Kao, Sreenivasulu Chintala, Ashley Orillion, May Elbanna, Remi Adelaiye-Ogala, Venkata Nithinsai Chintala, Khunsha Ahmed, Anthony C. Wood, Eric Kauffman, Sheng Yu Ku, Mary W. Ferris, Heba W.Z Khella, Justin A. Budka, Nur P. Damayanti
Pie chart for TFE3 binding sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec755bba719b072dc8d771e78e1611
https://doi.org/10.1158/1078-0432.22470083.v1
https://doi.org/10.1158/1078-0432.22470083.v1