Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Peter C, Harpel"'
Publikováno v:
Blood. 103:1296-1304
The response of the arterial vascular wall to injury is characterized by vascular smooth muscle cell (VSMC) migration, a process requiring metalloproteinase production. This migration is induced by cytokines, however the agonists involved are not ful
Publikováno v:
Blood. 97:39-45
The CC chemokine receptor 8 (CCR8) is expressed on monocytes and type 2 T lymphocytes. CCR8 is the sole receptor for the human CC chemokine I-309, as well as for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in h
Autor:
Thomas P. Sculco, George Go, Nigel E. Sharrock, Eduardo A. Salvati, Geoffrey H. Westrich, Peter C. Harpel
Publikováno v:
Anesthesiology. 90:981-987
Background Thrombogenesis in total hip replacement (THR) begins during surgery on the femur. This study assesses the effect of two doses of unfractionated intravenous heparin administered before femoral preparation during THR on circulating markers o
Autor:
Samin K. Sharma, Roxana Mehran, Geoffrey Dube, John T. Fallon, John A. Ambrose, George Dangas, Santica M. Marcovina, Peter C. Harpel
Publikováno v:
Journal of the American College of Cardiology. 32(7):2035-2042
Objectives. The purpose of this study was the investigation of the in vivo role of lipoprotein(a) [Lp(a)] and inflammatory infiltrates in the human coronary atherosclerotic plaque and their correlation with the clinical syndrome of presentation.Backg
Autor:
Peter C. Harpel, J. B. A. Ross, Elena Rusinova, Jacob H. Rand, Harry A.M. Andree, C. Calandri, Xiao-Xuan Wu, M. G. Gascon-Lema
Publikováno v:
Blood. 92:1652-1660
The antiphospholipid syndrome is a thrombophilic condition marked by antibodies that recognize anionic phospholipid-protein cofactor complexes. We recently reported that exposure to IgG fractions from antiphospholipid patients reduces the level of an
Publikováno v:
Biochemistry. 37:3949-3954
It has been well documented that Lp(a) binds noncovalently to fibrin or human umbilical vein endothelial cells. This binding is to lysines and is inhibited by lysine analogues such as epsilon-aminocaproic acid (EACA). In the present study, Lp(a) (0.0
Publikováno v:
Journal of Clinical Investigation. 100:2170-2181
Lp(a) is a major inherited risk factor associated with premature heart disease and stroke. The mechanism of Lp(a) atherogenicity has not been elucidated, but likely involves both its ability to influence plasminogen activation as well as its atheroge
Autor:
Xiao-Xuan Wu, Jacob H. Rand, Harry A.M. Andree, Jonathan Scher, Seth Guller, Peter C. Harpel, Charles J. Lockwood
Publikováno v:
New England Journal of Medicine. 337:154-160
The mechanisms of vascular thrombosis and pregnancy loss in the antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid-binding protein with potent anticoagulant activity, are markedly reduced on placental villi from women
Autor:
George Go, Peter C. Harpel, Michael J. Maynard, Chitranjan S. Ranawat, Nigel E. Sharrock, Thomas P. Sculco
Publikováno v:
The Journal of Arthroplasty. 10:523-528
Deep vein thrombosis may begin during surgery with the tourniquet inflated. Arterial levels of fibrinopeptide A, thrombin—antithrombin complexes, D-dimer, tissue plasminogen activator (t-PA) activity, and t-PA antigen were measured before surgery,
Publikováno v:
Journal of Biological Chemistry. 270:17929-17933
Tissue and plasma transglutaminases cross-link human plasminogen into high molecular weight complexes (Bendixen, E., Borth, W., and Harpel, P. C.(1993) J. Biol. Chem. 268, 21962-21967). A major cross-linking site in plasminogen involved in the tissue