Identification of inhibitors of heparin–growth factor interactions from combinatorial libraries of four-component condensation reactions

Autor: Jundong Zhang, Walter C. Herlihy, Sohail Hussein, Gretchen Grundstrom, Georgiana Rivers, Peter Burch, Alan Jacobson, Yanyi Zhu, Ariane Marolewski, James R. Rusche, James Peyers

Publikováno v: Bioorganic & Medicinal Chemistry. 9:825-836

Chemical libraries based on four-component condensation (4CC) reactions of isocyanides were constructed to identify compounds capable of blocking heparin binding to vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2115841302b64824390a57c6c6a41a3
https://doi.org/10.1016/s0968-0896(00)00317-5

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Autor: Wilkinson, Isabel V. L.¹ (AUTHOR), Perkins, Kelly J.² (AUTHOR), Dugdale, Hannah² (AUTHOR), Moir, Lee² (AUTHOR), Vuorinen, Aini¹ (AUTHOR), Chatzopoulou, Maria¹ (AUTHOR), Squire, Sarah E.² (AUTHOR), Monecke, Sebastian³ (AUTHOR), Lomow, Alexander³ (AUTHOR), Geese, Marcus³ (AUTHOR), Charles, Philip D.^4,5 (AUTHOR), Burch, Peter⁶ (AUTHOR), Tinsley, Jonathan M.⁶ (AUTHOR), Wynne, Graham M.¹ (AUTHOR), Davies, Stephen G.¹ (AUTHOR), Wilson, Francis X.⁶ (AUTHOR), Rastinejad, Fraydoon⁵ (AUTHOR), Mohammed, Shabaz^1,4 (AUTHOR), Davies, Kay E.² (AUTHOR), Russell, Angela J.^1,7 (AUTHOR) angela.russell@chem.ox.ac.uk

Publikováno v: Angewandte Chemie. 2/3/2020, Vol. 132 Issue 6, p2441-2449. 9p.

THINKING SMALL TO THINK BIG: LEADING FOR CHANGE.

Autor: Cincala, Petr¹

Publikováno v: Journal of Applied Christian Leadership. Fall2019, Vol. 13 Issue 2, p4-7. 4p.

Despite Major League Baseball's snubbing, the game's soul lives on in places like Batavia.

Autor: Pitoniak, Scott

Publikováno v: Rochester Business Journal. 7/15/2022, Vol. 37 Issue 36, p22-25. 2p.

WE SPEAK WHAT WE KNOW.

Publikováno v: Journal of Applied Christian Leadership. Spring2013, Vol. 7 Issue 1, p4-6. 3p.