Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Peter Buchwald"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
As part of our work to develop small-molecule inhibitors (SMIs) of the CD40-CD40L(CD154) costimulatory protein-protein interaction, here, we describe the ability of two of our most promising SMIs, DRI-C21041 and DRI-C21095, to prolong the survival an
Externí odkaz:
https://doaj.org/article/b9934ccfe1794acfa9cccb4774a29d1d
Autor:
Peter Buchwald
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Simple one-to three-parameter models routinely used to fit typical dose-response curves and calculate EC50 values using the Hill or Clark equation cannot provide the full picture connecting measured response to receptor occupancy, which can be quite
Externí odkaz:
https://doaj.org/article/6a4d0370f515439581abe98e0c0430ae
Autor:
Teresa De Toni, Teodora Dal Buono, Chris M. Li, Grisell C. Gonzalez, Sung-Ting Chuang, Peter Buchwald, Alice A. Tomei, Diana Velluto
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 652 (2024)
The need for chronic systemic immunosuppression, which is associated with unavoidable side-effects, greatly limits the applicability of allogeneic cell transplantation for regenerative medicine applications including pancreatic islet cell transplanta
Externí odkaz:
https://doaj.org/article/0de5a7d751664884a5137f7bbebdfae8
Autor:
Peter Buchwald
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Methods that allow quantification of receptor binding (occupancy) by measuring response (effect) data only are of interest as they can be used to allow characterization of binding properties (e.g., dissociation constant, K d) without having
Externí odkaz:
https://doaj.org/article/1e8673fe80b640309f457b320557de85
Autor:
Jerry Bonnell, Oscar Alcazar, Brandon Watts, Peter Buchwald, Midhat H. Abdulreda, Mitsunori Ogihara
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 492 (2024)
Background: Type 1 diabetes (T1D) is a devastating autoimmune disease, and its rising prevalence in the United States and around the world presents a critical problem in public health. While some treatment options exist for patients already diagnosed
Externí odkaz:
https://doaj.org/article/ffa67aaa54fc4a30a58171bdc8629ce7
Autor:
Dimitri Van Simaeys, Adriana De La Fuente, Serena Zilio, Alessia Zoso, Victoria Kuznetsova, Oscar Alcazar, Peter Buchwald, Andrea Grilli, Jimmy Caroli, Silvio Bicciato, Paolo Serafini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Development of probes specific for human β-cells could aid in delivery of therapeutics and monitoring β-cells mass during diabetes progression or islet transplantation. Here the authors identify two RNA aptamers specific for β-cells that allow eff
Externí odkaz:
https://doaj.org/article/13e8929c62214a04a74a270d1400d915
Autor:
Teresa De Toni, Aaron A. Stock, Floriane Devaux, Grisell C. Gonzalez, Kailyn Nunez, Jessica C. Rubanich, Susan A. Safley, Collin J. Weber, Noel M. Ziebarth, Peter Buchwald, Alice A. Tomei
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Pancreatic islet transplantation improves metabolic control and prevents complications in patients with brittle type 1 diabetes (T1D). However, chronic immunosuppression is required to prevent allograft rejection and recurrence of autoimmunity. Islet
Externí odkaz:
https://doaj.org/article/1c954b1b7ccd4905b8fd9ded78d1a4a3
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1444 (2022)
Background: Type 1 diabetes (T1D) is a devastating disease with serious health complications. Early T1D biomarkers that could enable timely detection and prevention before the onset of clinical symptoms are paramount but currently unavailable. Despit
Externí odkaz:
https://doaj.org/article/4ecb4ee4a58340a28d7baccf618cd6ac
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Kinsley Belle, Tamar Sapir, Fanuel Messaggio, Kevin B. Johnson, Oliver Umland, Darrell Hardin, Dagmar Klein, Ingrid Pérez-Álvarez, Fatima Sadiq, Oscar Alcázar, Luca A. Inverardi, Camillo Ricordi, Peter Buchwald, Christopher A. Fraker, Ricardo L. Pastori, Juan Domínguez-Bendala
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 611-623 (2019)
Summary: The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant
Externí odkaz:
https://doaj.org/article/4370bf27b2c441a0890f656127747865
Autor:
Sung-Ting Chuang, Peter Buchwald
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1084 (2022)
Therapeutically useful small-molecule inhibitors (SMIs) of protein–protein interactions (PPIs) initiating the cell attachment and entry of viruses could provide novel alternative antivirals that act via mechanisms similar to that of neutralizing an
Externí odkaz:
https://doaj.org/article/d52f33a932104cabb2a458d77d492dc4