Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Peter Boross"'
Autor:
Ida H. Hiemstra, Kim C.M. Santegoets, Maarten L. Janmaat, Bart E.C.G. De Goeij, Wessel Ten Hagen, Sanne van Dooremalen, Peter Boross, Jeroen van den Brakel, Sieto Bosgra, Grietje Andringa, Berris van Kessel-Welmers, Dennis Verzijl, Richard G. Hibbert, Kristine A. Frerichs, Tuna Mutis, Niels W.C.J. van de Donk, Tahamtan Ahmadi, David Satijn, A. Kate Sasser, Esther C.W. Breij
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104663- (2023)
Summary: Background: HexaBody®-CD38 (GEN3014) is a hexamerization-enhanced human IgG1 that binds CD38 with high affinity. The E430G mutation in its Fc domain facilitates the natural process of antibody hexamer formation upon binding to the cell surf
Externí odkaz:
https://doaj.org/article/f33bd39a5fdd41bc885381f56bdbe832
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/87916d2bef084c37b9158c43773f569b
Autor:
Kate Sasser, Kristel Kemper, Ellis Gielen, Mischa Houtkamp, Peter Boross, Stefanie De Poot, Patrick Engelberts, Bart de Goeij, David Satijn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/cba5dcfc8a634b10bc5ba77b06d69ba0
Autor:
Peter Boross, Stefan Lohse, Maaike Nederend, Johannes Hendrik Marco Jansen, Geert van Tetering, Michael Dechant, Matthias Peipp, Louise Royle, Li Phing Liew, Louis Boon, Nico van Rooijen, Wim K. Bleeker, Paul W. H. I. Parren, Jan G. J. van de Winkel, Thomas Valerius, Jeanette H. W. Leusen
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 8, Pp 1213-1226 (2013)
Abstract Currently all approved anti‐cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by
Externí odkaz:
https://doaj.org/article/329d97c0f4a14fd1a47447646d3dc7c0
Autor:
Peter Boross, J.H. Marco Jansen, Simone de Haij, Frank J. Beurskens, Cees E. van der Poel, Lisette Bevaart, Maaike Nederend, Josée Golay, Jan G.J. van de Winkel, Paul W.H.I. Parren, Jeanette H.W. Leusen
Publikováno v:
Haematologica, Vol 96, Iss 12 (2011)
Background CD20 monoclonal antibodies are widely used in clinical practice. Antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity and direct cell death have been suggested to be important effector functions for CD20 antibodies.
Externí odkaz:
https://doaj.org/article/a659aed66c1947d2853f66ffdd576053
Autor:
Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
Publikováno v:
Nature Biotechnology. 40:1509-1519
The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect®, an approach to enhance the functional selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37adbdc10c2c7fdd110d991a2ca6fa2f
https://doi.org/10.1038/s41587-022-01384-1
https://doi.org/10.1038/s41587-022-01384-1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
Supplementary figure legends and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c48370f8dc02403421b6b6be685237d
https://doi.org/10.1158/2326-6066.22537123.v1
https://doi.org/10.1158/2326-6066.22537123.v1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
Leukocyte-mediated cytotoxicity with IgG and IgA. 4 hour 51Cr-release assay by leukocytes using (A) A431 cells and (B) SK-BR-3 cells and 1 µg/ml mAb. Representative results of two (A) and four (B) experiments performed with different donors (Mean {p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba84ac6b42b6ec6082a4154802e930f
https://doi.org/10.1158/2326-6066.22537138.v1
https://doi.org/10.1158/2326-6066.22537138.v1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
Efficacy of anticancer monoclonal antibodies (mAb) is limited by the exhaustion of effector mechanisms. IgG mAbs mediate cellular effector functions through FcγRs expressed on effector cells. IgA mAbs can also induce efficient tumor killing both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c999899ed314911ffba086419467c90
https://doi.org/10.1158/2326-6066.c.6548326.v1
https://doi.org/10.1158/2326-6066.c.6548326.v1
Autor:
Peter Boross, Jeanette H.W. Leusen, Thomas Valerius, Stefan Lohse, Gerard Rouwendal, Ruud Ubink, István Németh, Sietse Q. Nagelkerke, M. Alejandra Beltrán Buitrago, J.H. Marco Jansen, Saskia Meyer, Geert van Tetering, Laura A.P.M. Meulenbroek, Maaike Nederend, Toine ten Broeke, Arianne M. Brandsma
PMN-mediated cytotoxicity is not increased by the combination of IgG and IgA against two targets. (A) Pooled data (8 donors) from ADCC assays were performed using purified PMNs isolated by Ficoll/Histopaque separation and A431-HER2 target cells eithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9e1bb9e3deea67e57db5a3b039e313
https://doi.org/10.1158/2326-6066.22537126.v1
https://doi.org/10.1158/2326-6066.22537126.v1