Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter Birk Rasmussen"'
Autor:
Peter Birk Rasmussen, Peter Staller
Publikováno v:
Epigenomics. 6:277-286
There is growing evidence for a causal role of the KDM5 family of histone demethylases in human cancer. In particular, KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) contribute to cancer cell proliferation, reduce the expression of tumor suppressor ge
Autor:
Anne Marie Wegener, Jørgen Rygaard, Peter Birk Rasmussen, Lene Sonderbye, Dana Leach, Søren Mouritsen, Anand Gautam, Lucilla Steinaa
Publikováno v:
The Journal of Immunology. 175:329-334
Transgenic mice expressing membrane-bound OVA under the rat insulin promoter, RIP-mOVA, has previously been suggested to display deletional tolerance toward the dominant CTL epitope, SIINFEKL, and provide an elegant model system to test the hypothesi
Autor:
Klaus Gregorius, Peter Birk Rasmussen, Tine Gottschalk, Søren Mouritsen, Valéry Renard, Lene Sonderbye, Kirsten Ebbehøj, Dana Leach, Anand Gautam
Publikováno v:
The Journal of Immunology. 171:1588-1595
Overexpression of the growth factor receptor HER-2 (c-erbB-2, neu) has transforming potential and occurs in ∼20–30% of breast and ovarian cancers. HER-2 is a self Ag, but Abs and T cells specific for HER-2 have been isolated from cancer patients,
Autor:
Laurens A. H. van Pinxteren, Peter Henrik Andersen, Peter Birk Rasmussen, Limei Meng Okkels, Anja Olsen
Publikováno v:
Infection and Immunity. 69:2773-2778
In this study, we investigated the potential of a tuberculosis subunit vaccine based on fusion proteins of the immunodominant antigens ESAT-6 and antigen 85B. When the fusion proteins were administered to mice in the adjuvant combination dimethyl dio
Autor:
Peter Højrup, Paolo Mascagni, Ida Rosenkrands, Anthony R.M. Coates, Mahavir Singh, Peter Birk Rasmussen, Karin Weldingh, Lise Ostergaard Brandt, Peter Andersen, Pernille Ravn
Publikováno v:
Infection and Immunity. 67:5552-5558
Mycobacterium tuberculosis GroES was purified from culture filtrate, and its identity was confirmed by immunoblot analysis and N-terminal sequencing. Comparing the immunological recognition of native and recombinant GroES, we found that whereas nativ
Autor:
Ida Rosenkrands, Brigitte Gicquel, Peter Henrik Andersen, Peter Birk Rasmussen, Fransois-Xavier Berthet
Publikováno v:
Microbiology. 144:3195-3203
SUMMARY: The early secreted antigenic target 6 kDa protein (ESAT-6) is a potent T-cell protein antigen synthesized by Mycobacterium tuberculosis. Its corresponding gene (esat-6) is located in RD1, a 10 kb DNA region deleted in the attenuated tubercul
Autor:
Martin J Elhay, Peter Andersen, Susanne Jacobsen, Ida Rosenkrands, Karin Weldingh, Peter Birk Rasmussen
Publikováno v:
Infection and Immunity. 66:3492-3500
Culture filtrate from Mycobacterium tuberculosis contains molecules which promote high levels of protective immunity in animal models of subunit vaccination against tuberculosis. We have used two-dimensional electrophoresis for analysis and purificat
Autor:
Susanne Jacobsen, Markus C. Carnio, Ida Rosenkrands, Peter Andersen, Michael Theisen, Peter Birk Rasmussen
Publikováno v:
Infection and Immunity. 66:2728-2735
Culture filtrate proteins from Mycobacterium tuberculosis induce protective immunity in various animal models of tuberculosis. Two molecular mass regions (6 to 10 kDa and 24 to 36 kDa) of short-term culture filtrate are preferentially recognized by T
Publikováno v:
Scandinavian journal of immunology. 67(2)
It is of major importance to overcome the immunological tolerance in attempts to generate efficient tumour vaccines. Here, we describe induction of autoantibodies and self-reactive CTL in three types of OVA-transgenic mouse strains, RIP-OVA(low), RIP
Publikováno v:
Scandinavian journal of immunology. 65(3)
The aim of this study was to evaluate the effect of including a foreign T helper cell epitope in vaccines designed for generation of CTL against self-antigens and for inhibition of tumour growth. Two different vaccine designs were composed, a minimal