Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Peter Bielecki"'
Autor:
Gil Covarrubias, Yahan Zhang, Morgan E Lorkowski, Efstathios Karathanasis, Prabhani U. Atukorale, Taylor J. Moon, Wyatt M. Becicka, Peter Bielecki
Publikováno v:
Nanoscale Advances
The efficacy of immunotherapies is often limited by the immunosuppressive tumor microenvironment, which is populated with dysfunctional innate immune cells. To reprogram the tumor-resident innate immune cells, we developed immunostimulatory silica me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067d39c4f683825a77fb0f0fcbe2173
http://europepmc.org/articles/PMC8386411
http://europepmc.org/articles/PMC8386411
Autor:
Prabhani U. Atukorale, Morgan E Lorkowski, Peter Bielecki, Efstathios Karathanasis, A.R. Santulli, Georgia Loutrianakis, Yahan Zhang, Kathleen Tong, Taylor Moon, Wyatt M. Becicka, Gil Covarrubias
Publikováno v:
J Control Release
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease, where even surgical resection and aggressive chemotherapy produce dismal outcomes. Immunotherapy is a promising alternative to conventional treatments, possessing the ability to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7e18e5df5f36357059434ad1989d82
https://doi.org/10.1016/j.jconrel.2020.11.014
https://doi.org/10.1016/j.jconrel.2020.11.014
Autor:
Gil Covarrubias, Taylor J. Moon, Shruthi Ravichandran, Efstathios Karathanasis, Prabhani U. Atukorale, Peter Bielecki, Michelle L. Wiese, Morgan E Lorkowski, Yahan Zhang, Wyatt M. Becicka
Publikováno v:
Nanoscale Horiz
The high mortality associated with glioblastoma multiforme (GBM) is attributed to its invasive nature, hypoxic core, resistant cell subpopulations and a highly immunosuppressive tumor microenvironment (TME). To support adaptive immune function and es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238583809ad92855af05a8e979d250e9
https://doi.org/10.1039/d0nh00446d
https://doi.org/10.1039/d0nh00446d
Publikováno v:
J Control Release
In situ forming implants (ISFIs) allow for a high initial intratumoral concentration and sustained release of the chemotherapeutic. However, clinical translation is impeded primarily due to limited drug penetration from the tumor/boundary interface a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3e2b3f38d4f80996abbe2693752ba4
https://doi.org/10.1016/j.jconrel.2020.05.003
https://doi.org/10.1016/j.jconrel.2020.05.003
Autor:
Mayura P Umapathy, Gil Covarrubias, Morgan E Lorkowski, Taylor J. Moon, Prabhani U. Atukorale, Georgia Loutrianakis, Haley M. Sims, Michelle L. Wiese, Efstathios Karathanasis, Peter Bielecki
Publikováno v:
J Mater Chem B
To alter the immunosuppressive tumor microenvironment (TME), we developed an immunostimulatory nanoparticle (NP) to reprogram a tumor’s dysfunctional and inhibitory antigen-presenting cells (APCs) into properly activated APCs that stimulate tumor-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0b7261985c46e73d2c9810600885e7
https://europepmc.org/articles/PMC8732314/
https://europepmc.org/articles/PMC8732314/
Autor:
S. Raghunathan, Gil Covarrubias, Efstathios Karathanasis, Taylor J. Moon, Carolyn Zheng, Peter Bielecki, Vanitha Raguveer, Christopher J. Hoimes, Amy Goldberg, Michelle L. Wiese, Prabhani U. Atukorale
Publikováno v:
Cancer Research. 79:5394-5406
Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites to generate powerful antitumor immune responses w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f143e9d6b9ff892d658fd979beb7aa31
https://doi.org/10.1158/0008-5472.can-19-0381
https://doi.org/10.1158/0008-5472.can-19-0381
Autor:
Peter Bielecki, Pinunta Nittayacharn, Agata A. Exner, Christopher Hernandez, Hai-Xia Yuan, Haoyan Zhou
Publikováno v:
J Pharm Sci
Issues with limited intratumoral drug penetration and heterogeneous drug distribution continue to impede the therapeutic efficacy of nanomedicine-based delivery systems. Ultrasound-enhanced drug delivery has emerged as one effective means of overcomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb39df941472351e7bb9113d0fac2c8
https://doi.org/10.1016/j.xphs.2019.05.004
https://doi.org/10.1016/j.xphs.2019.05.004
Autor:
Pubudu M. Peiris, Gil Covarrubias, Abdelrahman Rahmy, Kathleen Tong, Shane Cooley, Taylor Moon, Efstathios Karathanasis, Youngjun Park, Peter Bielecki, Ketan B. Ghaghada, Oguz Turan
Publikováno v:
Mol Pharm
Deposition of nanoparticles to tumors often can be enhanced by targeting receptors overexpressed in a tumor. However, a tumor may exhibit a finite number of a biomarker that is accessible and targetable by nanoparticles, limiting the available landin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df18434bacfd28aeba88bcd5706ee0c6
https://doi.org/10.1021/acs.molpharmaceut.9b00693
https://doi.org/10.1021/acs.molpharmaceut.9b00693
Autor:
Kathleen Tong, Taylor Moon, Pubudu M. Peiris, Aaron Yun, S. Raghunathan, Youngjun Park, Vindya S. Perera, Gil Covarrubias, Morgan E Lorkowski, Mark A. Griswold, Oguz Turan, Deobrat Dixit, Jeremy N. Rich, Georgia Loutrianakis, Efstathios Karathanasis, Shane Cooley, Peter Bielecki, Ketan B. Ghaghada
Publikováno v:
Adv Ther (Weinh)
Glioblastomas (GBMs) remain highly lethal. This partially stems from the presence of brain tumor initiating cells (BTICs), a highly plastic cellular subpopulation that is resistant to current therapies. In addition to resistance, the blood-brain barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20dc28fed7d9bd43bb123b2d063ead
https://pubmed.ncbi.nlm.nih.gov/32953978
https://pubmed.ncbi.nlm.nih.gov/32953978
Autor:
Gil Covarrubias, Ramamurthy Gopalakrishnan, S. Raghunathan, Pubudu M. Peiris, Abdelrahman Rahmy, Kathleen Tong, Mark A. Griswold, Morgan E Lorkowski, T Ouyang, A Yun, Efstathios Karathanasis, Vindya S. Perera, Peter Bielecki, Ketan B. Ghaghada, Oguz Turan
Publikováno v:
Nanoscale
Glioblastomas are highly lethal cancers defined by resistance to conventional therapies and rapid recurrence. While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a37b73b948b75fa950e969742ddf55f
https://europepmc.org/articles/PMC7776621/
https://europepmc.org/articles/PMC7776621/