Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Peter Bedner"'
Autor:
Peter Bedner, Christian Steinhäuser
Publikováno v:
Cells, Vol 12, Iss 12, p 1669 (2023)
The gap-junction-coupled astroglial network plays a central role in the regulation of neuronal activity and synchronisation, but its involvement in the pathogenesis of neuronal diseases is not yet understood. Here, we present the current state of kno
Externí odkaz:
https://doaj.org/article/2893151a1b7a483c90aecf5c25208966
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Blood–brain barrier (BBB) dysfunction following brain insults has been associated with the development and progression of focal epilepsy, although the underlying molecular mechanisms are not fully elucidated yet. Activation of transforming growth f
Externí odkaz:
https://doaj.org/article/a3bcdd17b7ce4d19902ebd00e5beb561
Autor:
Julia Müller, Aline Timmermann, Lukas Henning, Hendrik Müller, Christian Steinhäuser, Peter Bedner
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
An imbalance of excitation and inhibition has been associated with the pathophysiology of epilepsy. Loss of GABAergic interneurons and/or synaptic inhibition has been shown in various epilepsy models and in human epilepsy. Despite this loss, several
Externí odkaz:
https://doaj.org/article/147e6ad988c0446dab8a0e8c24dded0e
Autor:
Jiong Zhang, Pavel Dublin, Stephanie Griemsmann, Alexandra Klein, Ralph Brehm, Peter Bedner, Bernd K Fleischmann, Christian Steinhäuser, Martin Theis
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82818 (2013)
Herein we demonstrate with PCR, immunodetection and reporter gene approaches that the widely used human Glial Fibrillary Acidic Protein (hGFAP)-Cre transgene exhibits spontaneous germ-line recombination activity in leading to deletion in brain, heart
Externí odkaz:
https://doaj.org/article/2155fe001cfc497b98c178e24ea912b6
Autor:
Annamaria Vezzani, Teresa Ravizza, Peter Bedner, Eleonora Aronica, Christian Steinhäuser, Detlev Boison
Publikováno v:
Vezzani, A, Ravizza, T, Bedner, P, Aronica, E, Steinhäuser, C & Boison, D 2022, ' Astrocytes in the initiation and progression of epilepsy ', Nature Reviews Neurology, vol. 18, no. 12, pp. 707-722 . https://doi.org/10.1038/s41582-022-00727-5
Epilepsy affects ~65 million people worldwide. First-line treatment options include >20 antiseizure medications, but seizure control is not achieved in approximately one-third of patients. Antiseizure medications act primarily on neurons and can prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46b9b398b98a68a1a073289138299e2
https://doi.org/10.1038/s41582-022-00727-5
https://doi.org/10.1038/s41582-022-00727-5
Autor:
Christian Steinhauser, Peter Bedner
The gap junction-coupled astroglial network plays a central role in the regulation of neuronal activity and synchronization, but its involvement in the pathogenesis of neuronal diseases is not yet understood. Here we present the current state of know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd1cf79a6bdf79862710d369dd2150e
https://doi.org/10.20944/preprints202301.0531.v1
https://doi.org/10.20944/preprints202301.0531.v1
Autor:
Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner
Publikováno v:
Glia 71(2), 168-186 (2023). doi:10.1002/glia.24265
Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and progression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7febe93f8d8c48e53108d8572a2f2a1d
Autor:
Gerald Seifert, Tushar Deshpande, Zhou Wu, Lukas Henning, Peter Bedner, Christian Steinhäuser
Publikováno v:
Epilepsia. 62:1569-1583
Objective Growing evidence suggests that dysfunctional astrocytes are crucial players in the development of mesial temporal lobe epilepsy (MTLE). Using a mouse model closely recapitulating key alterations of chronic human MTLE with hippocampal sclero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858207aa693223efafd7f516e32bbac1
https://doi.org/10.1111/epi.16910
https://doi.org/10.1111/epi.16910
Publikováno v:
EpilepsiaREFERENCES. 62(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062d98fc7b69e7b8a022aee560db4b7c
https://pubmed.ncbi.nlm.nih.gov/34169508
https://pubmed.ncbi.nlm.nih.gov/34169508
Publikováno v:
Glia. 68:756-767
Since animal models are inevitable for medical research, information on species differences in glial cell properties is critical for successful translational research. Here, we review current knowledge about morphological and functional properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b4b72094c19bc1c6d9ff12ca81892d
https://doi.org/10.1002/glia.23725
https://doi.org/10.1002/glia.23725