Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Peter Bacchetti"'
Autor:
John Metcalfe, Peter Bacchetti, Ali Esmail, Andrew Reckers, David Aguilar, Anita Wen, Shu Huo, Winnie R. Muyindike, Judith A. Hahn, Keertan Dheda, Monica Gandhi, Roy Gerona
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-6 (2021)
Abstract Background Treatment monitoring of drug-resistant tuberculosis (DR-TB) in resource-limited settings is challenging. We developed a multi-analyte assay for eleven anti-TB drugs in small hair samples as an objective metric of drug exposure. Me
Externí odkaz:
https://doaj.org/article/5b618f2ac378424e89b3031a392f66da
Autor:
Peter Bacchetti, Ronald J. Bosch, Eileen P. Scully, Xutao Deng, Michael P. Busch, Steven G. Deeks, Sharon R. Lewin
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss 3, Pp 167-173 (2019)
Observational and interventional studies for HIV cure research often use single-copy assays to quantify rare entities in blood or tissue samples. Statistical analysis of such measurements presents challenges due to tissue sampling variability and fre
Externí odkaz:
https://doaj.org/article/45874b23dd1f4e00b368f4f1834cabe6
Autor:
Jennifer M. Zerbato, Georges Khoury, Wei Zhao, Matthew J. Gartner, Rachel D. Pascoe, Ajantha Rhodes, Ashanti Dantanarayana, Megan Gooey, Jenny Anderson, Peter Bacchetti, Steven G. Deeks, James McMahon, Michael Roche, Thomas A. Rasmussen, Damian FJ Purcell, Sharon R. Lewin
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103241- (2021)
Background: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretroviral therapy (ART) is to activate latent HIV infection with a latency reversing agent (LRA). Surrogate markers that acc
Externí odkaz:
https://doaj.org/article/d906ec4beead49649c5521b1bb6e22dd
Autor:
Monica Gandhi, Peter Bacchetti, Warren C. Rodrigues, Matthew Spinelli, Catherine A. Koss, Paul K. Drain, Jared M. Baeten, Nelly R. Mugo, Kenneth Ngure, Leslie Z. Benet, Hideaki Okochi, Guohong Wang, Michael Vincent
Publikováno v:
EClinicalMedicine, Vol 2, Iss , Pp 22-28 (2018)
Background: Pharmacologic adherence measures were critical to the interpretation of the tenofovir (TFV)-disoproxil-fumarate/emtricitabine (TDF/FTC) PrEP trials. These measures are being incorporated into PrEP demonstration projects, but currently-ava
Externí odkaz:
https://doaj.org/article/bf8ce0e7374745d894c34567e5444ee8
Autor:
Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR). However, little is known concerning the rol
Externí odkaz:
https://doaj.org/article/377bcc8697144c61b0cfa77b4a969d0c
Publikováno v:
ERJ Open Research, Vol 5, Iss 2 (2019)
Therapeutic drug monitoring for drug-resistant tuberculosis (TB) is likely to improve treatment outcomes. While assessments of plasma drug levels can explain pharmacokinetic variability among trial participants, these measures require phlebotomy and
Externí odkaz:
https://doaj.org/article/679e962a542c4e5889fb7f7e396fc96f
Autor:
Daniel I S Rosenbloom, Peter Bacchetti, Mars Stone, Xutao Deng, Ronald J Bosch, Douglas D Richman, Janet D Siliciano, John W Mellors, Steven G Deeks, Roger G Ptak, Rebecca Hoh, Sheila M Keating, Melanie Dimapasoc, Marta Massanella, Jun Lai, Michele D Sobolewski, Deanna A Kulpa, Michael P Busch, Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006849 (2019)
Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4+ T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing HIV-1. Efforts to reduce the reservoir require assays that can reliably quantify its size
Externí odkaz:
https://doaj.org/article/b5955aac1a054bdaae557617f2bee089
Autor:
Ruth Greenblatt, Peter Bacchetti, Ross Boylan, Kord Kober, Gayle Springer, Kathryn Anastos, Michael Busch, Mardge Cohen, Seble Kassaye, Deborah Gustafson, Bradley Aouizerat, Women’s Interagency HIV Study
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0219201 (2019)
Increase of peripheral blood CD4 lymphocyte counts is a key goal of combined antiretroviral therapy (cART); most, but not all, recipients respond adequately and promptly. A small number of studies have examined specific genetic factors associated wit
Externí odkaz:
https://doaj.org/article/8133b9fb9dab456eba3c52d6544e9e2d
Autor:
Sanjiv M Baxi, Eric Vittinghoff, Peter Bacchetti, Yong Huang, Kata Chillag, Ryan Wiegand, Peter L Anderson, Robert Grant, Ruth M Greenblatt, Susan Buchbinder, Monica Gandhi, Albert Y Liu
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190118 (2018)
CLINICAL TRIAL REGISTRATION:Clinical Trials.gov NCT00131677.
Externí odkaz:
https://doaj.org/article/387a75c9d8f940a4b453bfd8f3066f64
Autor:
Vidya Mave, Aarti Kinikar, Anju Kagal, Smita Nimkar, Hari Koli, Sultanat Khwaja, Renu Bharadwaj, Roy Gerona, Anita Wen, Geetha Ramachandran, Hemanth Kumar, Peter Bacchetti, Kelly E Dooley, Nikhil Gupte, Amita Gupta, Monica Gandhi
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189101 (2017)
We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure p
Externí odkaz:
https://doaj.org/article/08a24d8f9ac748c4942cdf3905900ca9