Výsledky vyhledávání - "Peter Baatsen"

O5‐04‐01: MOLECULAR MECHANISMS OF ABETA‐INDUCED TAU‐PATHOLOGY: ANALYSIS OF CROSS‐SEEDING OF ABETA AND TAU AND ITS ROLE IN PRION‐LIKE PROPAGATION OF TAU‐PATHOLOGY IN VITRO AND IN VIVO

Autor: Pascal Kienlen-Campard, Kristof Van Kolen, Ilie-Cosmin Stancu, Arjan Buist, Peng Wang, Diederik Moechars, Jean-Noël Octave, Bruno Barbosa de Vasconcelos, An Verheyen, Peter Baatsen, Alexandre Vanoosthuyse, Matthew Bird, Ilse Dewachter

Publikováno v: Alzheimer's & Dementia. 12

tissue homogenates with exogenous Ab1-42 under multiple conditions. Samples were analyzed using acid urea gels followed by Western blotting. Results:The PDAPP mice study revealed Ab42 to Ab40 conversion over time reaching equilibrium by 72hr. Acid ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418e76db5a051e97cae16325022b2b2b
https://doi.org/10.1016/j.jalz.2016.06.722

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Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

Autor: Matthew Bird, Pascal Kienlen-Campard, Kristof Van Kolen, An Verheyen, Diederik Moechars, Ilse Dewachter, Ilie-Cosmin Stancu, Bruno Barbosa de Vasconcelos, Peter Baatsen, Jean-Noël Octave, Alexandre Vanoosthuyse, Arjan Buist, Peng Wang

Publikováno v: Article
Acta Neuropathologica

Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ) induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in conversion from preclinical cognitively normal to Alzheimer's Diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf0320ae313e966d576f12757537df5

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Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

Autor: Dick Terwel, Tutu Oyelami, Diederik Moechars, Jean-Noël Octave, Ilse Dewachter, Agnès Villers, Guy Bormans, Ilie-Cosmin Stancu, Arjan Buist, Peng Wang, Peter Baatsen, Nathalie Pierrot, Eve Peeraer, Laurence Ris, Cindy Casteels, Bruno Barbosa de Vasconcelos, Pascal Kienlen-Campard

Publikováno v: Article
Acta Neuropathologica

Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally and may underlie the stereotyped progression of neurodegenerative Tauopathies. However, the involvement of templated misfolding of Tau in neuronal network dysfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26034241329360ff583fb6825f1646dc

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