Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Peter B. Stathopulos"'
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109699- (2024)
Summary: The mitochondrial calcium (Ca2+) uniporter (MCU) complex is regulated via integration of the MCU dominant negative beta subunit (MCUb), a low conductance paralog of the main MCU pore forming protein. The MCU amino (N)-terminal domain (NTD) a
Externí odkaz:
https://doaj.org/article/348c143208ee4c069cbc9ec6d8996af4
Autor:
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112155- (2023)
Summary: The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance of this competition rem
Externí odkaz:
https://doaj.org/article/324fd2ad3fb9463fa4701a04cb364947
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11605 (2022)
Lens gap junctions (GJs) formed by Cx46 and Cx50 are important to keep lens transparency. Functional studies on Cx46 and Cx50 GJs showed that the Vj-gating, single channel conductance (γj), gating polarity, and/or channel open stability could be mod
Externí odkaz:
https://doaj.org/article/8bd78b1ce96245f49125901f352ce359
Autor:
Joshua J. Woods, Neeharika Nemani, Santhanam Shanmughapriya, Akshay Kumar, MengQi Zhang, Sarah R. Nathan, Manfred Thomas, Edmund Carvalho, Karthik Ramachandran, Subramanya Srikantan, Peter B. Stathopulos, Justin J. Wilson, Muniswamy Madesh
Publikováno v:
ACS Central Science, Vol 5, Iss 1, Pp 153-166 (2019)
Externí odkaz:
https://doaj.org/article/c11a3ac499984fe6bac920a1430a4843
Autor:
Neeharika Nemani, Edmund Carvalho, Dhanendra Tomar, Zhiwei Dong, Andrea Ketschek, Sarah L. Breves, Fabián Jaña, Alison M. Worth, Julie Heffler, Palaniappan Palaniappan, Aparna Tripathi, Ramasamy Subbiah, Massimo F. Riitano, Ajay Seelam, Thomas Manfred, Kie Itoh, Shuxia Meng, Hiromi Sesaki, William J. Craigen, Sudarsan Rajan, Santhanam Shanmughapriya, Jeffrey Caplan, Benjamin L. Prosser, Donald L. Gill, Peter B. Stathopulos, Gianluca Gallo, David C. Chan, Prashant Mishra, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1005-1019 (2018)
Summary: Mitochondria shape cytosolic calcium ([Ca2+]c) transients and utilize the mitochondrial Ca2+ ([Ca2+]m) in exchange for bioenergetics output. Conversely, dysregulated [Ca2+]c causes [Ca2+]m overload and induces permeability transition pore an
Externí odkaz:
https://doaj.org/article/d8a52722cb5c491eaab6dfcbe01c7e01
Autor:
Donglin Bai, Jiayi Wang, Tianhe Li, Ryan Chan, Mena Atalla, Robert C. Chen, Mohammad T. Khazaneh, Raphael J. An, Peter B. Stathopulos
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7832 (2021)
Twenty-one human genes encode connexins, a family of homologous proteins making gap junction (GJ) channels, which mediate direct intercellular communication to synchronize tissue/organ activities. Genetic variants in more than half of the connexin ge
Externí odkaz:
https://doaj.org/article/994e3daa83bb43a8a02a9efe19ae7f76
Autor:
Megan Noble, Qi-Tong Lin, Christian Sirko, Jacob A. Houpt, Matthew J. Novello, Peter B. Stathopulos
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3642 (2020)
Calcium (Ca2+) is a universal signaling ion that is essential for the life and death processes of all eukaryotes. In humans, numerous cell stimulation pathways lead to the mobilization of sarco/endoplasmic reticulum (S/ER) stored Ca2+, resulting in t
Externí odkaz:
https://doaj.org/article/ed89a9a083c645529c6d916ad3e7e280
Autor:
Qi-Tong Lin, Peter B. Stathopulos
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 286 (2019)
Mitochondrial calcium (Ca2+) uptake shapes cytosolic Ca2+ signals involved in countless cellular processes and more directly regulates numerous mitochondrial functions including ATP production, autophagy and apoptosis. Given the intimate link to both
Externí odkaz:
https://doaj.org/article/fd0c136fa7fc450bb5f14c11899a5283
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3316 (2018)
Stromal interaction molecule (STIM)-1 and -2 regulate agonist-induced and basal cytosolic calcium (Ca2+) levels after oligomerization and translocation to endoplasmic reticulum (ER)-plasma membrane (PM) junctions. At these junctions, the STIM cytosol
Externí odkaz:
https://doaj.org/article/f9aa33eb700640098269cd3a1f0ea489
Autor:
QiTong Lin, Peter B. Stathopulos
Publikováno v:
Biophysical Journal. 122:518a-519a