Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Peter B. Rupert"'
Autor:
Jennifer N. Wacker, Joshua J. Woods, Peter B. Rupert, Appie Peterson, Marc Allaire, Wayne W. Lukens, Alyssa N. Gaiser, Stefan G. Minasian, Roland K. Strong, Rebecca J. Abergel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of alpha particles to eradicate cancerous cells. Actinium-225 [225Ac; t1/2 = 9.920(3) days] is an alpha-emitting radioisotope driving the next generat
Externí odkaz:
https://doaj.org/article/b852e100a7e24175a5eaf16faeb613d7
Autor:
Peter B. Rupert, Matthew Buerger, Emily J. Girard, Marie Frutoso, Don Parrilla, Kevin Ng, Theodore Gooley, Veronika Groh, Roland K. Strong
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28583- (2024)
NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis. Current therapeutic efforts targeting this axis almost exclusively aim at enhancing NKG2D-mediat
Externí odkaz:
https://doaj.org/article/ff64ffa78a71418689ec662a6f844c00
Autor:
Ida Lin, Peter B. Rupert, Kristina Pilat, Raymond O. Ruff, Della J. Friend, Man Kid Chan, Midori Clarke, Benjamin G. Hoffstrom, Jane Carter, Soheil Meshinchi, Ashok D. Bandaranayake, Christopher Mehlin, James M. Olson, Roland K. Strong, Colin E. Correnti
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin’s precise biological function and overall
Externí odkaz:
https://doaj.org/article/4119894bb87a422e91bef3d667f1bb92
Autor:
Kathryn A. K. Finton, Peter B. Rupert, Della J. Friend, Ana Dinca, Erica S. Lovelace, Matthew Buerger, Domnita V. Rusnac, Ulysses Foote-McNabb, William Chour, James R. Heath, Jean S. Campbell, Robert H. Pierce, Roland K. Strong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MHC class I “single-chain trimer” molecules, coupling MHC heavy chain, β2-microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To more fully understand caveats associated with this design that may a
Externí odkaz:
https://doaj.org/article/738bbd7365bf4134a8132bf3cd7b009a
Autor:
Matthew C. Clifton, Peter B. Rupert, Trisha M. Hoette, Kenneth N. Raymond, Rebecca J. Abergel, Roland K. Strong
Publikováno v:
Journal of Structural Biology: X, Vol 2, Iss , Pp - (2019)
Siderocalin/Lipocalin 2/Neutrophil Gelatinase Associated Lipocalin/24p3 is an innate immune system protein with bacteriostatic activity, acting by tightly binding and sequestering diverse catecholate and mixed-type ferric siderophores from enteric ba
Externí odkaz:
https://doaj.org/article/19f4706a2fbd4910b68af3fc9a07266d
Autor:
Jonathan Barasch, Maria Hollmen, Rong Deng, Eldad A. Hod, Peter B. Rupert, Rebecca J. Abergel, Benjamin E. Allred, Katherine Xu, Shaun F. Darrah, Yared Tekabe, Alan Perlstein, Rebecca Wax, Efrat Bruck, Jacob Stauber, Kaitlyn A. Corbin, Charles Buchen, Vesna Slavkovich, Joseph Graziano, Steven L. Spitalnik, Guanhu Bao, Roland K. Strong, Andong Qiu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demo
Externí odkaz:
https://doaj.org/article/3ae332e27072492dad5e0ff733401a56
Autor:
Zachary R. Crook, Emily J. Girard, Gregory P. Sevilla, Mi-Youn Brusniak, Peter B. Rupert, Della J. Friend, Mesfin M. Gewe, Midori Clarke, Ida Lin, Raymond Ruff, Fiona Pakiam, Tinh-Doan Phi, Ashok Bandaranayake, Colin E. Correnti, Andrew J. Mhyre, Natalie W. Nairn, Roland K. Strong, James M. Olson
Publikováno v:
Sci Transl Med
Cystine-dense peptides (CDPs) are a miniprotein class that can drug difficult targets with high affinity and low immunogenicity. Tools for their design, however, are not as developed as those for small-molecule and antibody drugs. CDPs have diverse t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a46236faa6f7cef167144b245fa628
https://europepmc.org/articles/PMC10118748/
https://europepmc.org/articles/PMC10118748/
Autor:
Justas V. Rodarte, Carly Baehr, Dustin Hicks, Tyler L. Liban, Connor Weidle, Peter B. Rupert, Rajwana Jahan, Abigail Wall, Andrew T. McGuire, Roland K. Strong, Scott Runyon, Marco Pravetoni, Marie Pancera
Publikováno v:
Structure. 31:20-32.e5
Opioid-related fatal overdoses have reached epidemic proportions. Because existing treatments for opioid use disorders offer limited long-term protection, accelerating the development of newer approaches is critical. Monoclonal antibodies (mAbs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4debf8dd8996df27c42d164ff9e81383
https://doi.org/10.1016/j.str.2022.11.008
https://doi.org/10.1016/j.str.2022.11.008
Autor:
Peter B. Rupert, Meei-Li Huang, Haiying Zhu, Andrew Fiore-Gartland, Arnold Park, Colleen McLaughlin, Chance Brock, April K. Randhawa, Roland K. Strong, Maurine D. Miner, Yixuan J. Hou, Matthew Buerger, Ralph S. Baric, Emily S Ford, Leonidas Stamatatos, Anton M Sholukh, Hannah Kaiser, Russell St Germain, Florian A. Lempp, Keith R. Jerome, Andrew B. Stuart, Joyce Y C Lu, Emily L Bossard, Bhanupriya Madarampalli, Margaret K. Doll, Jia Jin Kee, Kurt Diem, Lawrence Corey, Longping V. Tse, David C. Montefiori
Publikováno v:
Journal of Clinical Microbiology
Determinants of protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection require the development of well-standardized, reproducible antibody assays. This need has led to the emergence of a variety of neutrali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f66dbd89812d4e1725fc2b6b6e800f
https://pubmed.ncbi.nlm.nih.gov/34288726
https://pubmed.ncbi.nlm.nih.gov/34288726
Autor:
Zachary R. Crook, Emily J. Girard, Gregory P. Sevilla, Mi-Youn Brusniak, Peter B. Rupert, Della J. Friend, Mesfin M. Gewe, Midori Clarke, Ida Lin, Raymond Ruff, Doan Phi, Ashok Bandaranayake, Colin E. Correnti, Andrew J. Mhyre, Natalie W. Nairn, Roland K. Strong, James M. Olson
Publikováno v:
Cancer Research. 82:1043-1043
Cystine-dense peptides (CDPs) are a class of drug-like miniproteins that marry many of the advantages of biologics (high affinity and specificity) and small molecule therapeutics (high tissue permeability and low immunogenicity). The beneficial prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0287b019b3ff295e46cf0ae65b380096
https://doi.org/10.1158/1538-7445.am2022-1043
https://doi.org/10.1158/1538-7445.am2022-1043