Factor VIII with a 237 amino acid B‐domain has an extended half‐life in F8‐knockout mice

Autor: Gert Bolt, Peter B. Johansen, Helle Heibroch Petersen, Henrik Rahbek-Nielsen, D. M. Karpf, Peder Lisby Nørby, Mette Loftager, Marianne Kjalke, Lars Thim, E. Bloem, G. E. Blouse

Publikováno v: Journal of Thrombosis and Haemostasis. 17:350-360

Essentials Factor (F)VIII with an intermediate-length B-domain showed higher levels in murine gene therapy. FVIII with different B-domain lengths were analysed. FVIII variants with B-domains between 186 and 240 amino acids (aa) have extended half-lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71795725da862caf2148eb40463f37e
https://doi.org/10.1111/jth.14355

Prophylactic administration of glycoPEGylated factor IX provides protection and joint outcome superior to recombinant factor IX after induced joint bleeding

Autor: Tom Knudsen, Eric W. Livingston, Mirella Ezban, Ted A. Bateman, Peter B. Johansen, Sarah Taves, Mie L Broberg, Carsten Dan Ley, Junjiang Sun, Paul E. Monahan

Publikováno v: Journal of thrombosis and haemostasis : JTH. 17(8)

Background Following induced joint hemorrhage, hemophilia B results in the abnormal persistence of iron deposition, inflammation, and neovascularity of the synovial tissue, as well as deterioration of the bone articular surface and strength. Previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d0749ce9e7d6e9ff13474713a11781
https://pubmed.ncbi.nlm.nih.gov/31148392

Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis

Autor: Maureane Hoffman, Eric W. Livingston, Peter B. Johansen, Junjiang Sun, Baolai Hua, Mirella Ezban, Ted A. Bateman, Paul E. Monahan, Dougald M. Monroe, Sarah Taves

Publikováno v: Blood. 129(15)

Wound healing requires interactions between coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Healing in dermal wounds of hemophilia B mice is delayed when compared with hemostatically normal wild-type (WT) mice, with ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19577acbe8591a3c0c03538bdce6757
https://pubmed.ncbi.nlm.nih.gov/28408422

Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats

Autor: Niels Kristian Aagaard, Jacob Greisen, Kjell Malmlöf, Henning Grønbæk, Hendrik Vilstrup, Niels Tygstrup, Hans Ørskov, Peter B. Johansen, Thorbjørn Grøfte

Publikováno v: Aagaard, N K, Grøfte, T, Greisen, J, Malmlöf, K, Johansen, P B, Grønbæk, H, Ørskov, H, Tygstrup, N & Vilstrup, H 2009, ' Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats ', Growth Hormone & IGF Research, vol. 19, no. 5, pp. 426-31 . https://doi.org/10.1016/j.ghir.2009.01.001

Udgivelsesdato: 2009-Oct OBJECTIVES: Growth hormone (GH) reduces the catabolic side effects of steroid treatment via effects on the amino-nitrogen metabolism. Ipamorelin is a synthetic peptide with GH releasing properties. We wished to study the meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a3f442b1552e5ec5123e7eeb96779f
https://doi.org/10.1016/j.ghir.2009.01.001

Increase of Neuronal Histamine in Obese Rats Is Associated with Decreases in Body Weight and Plasma Triglycerides*

Autor: Peter B. Johansen, Birgitte Schjellerup Wulff, Hanne H. F. Refsgaard, Kjell Malmlöf, Valeria Golozoubova, Thomas I. F. H. Cremers, Karin Rimvall, Bernd Peschke

Publikováno v: Obesity. 14:2154-2162

Objective: The purpose of the present study was to examine the metabolic effects of a specific histamine H3 receptor antagonist, the cinnamic amide NNC 0038-0000-1202 (NNC 38-1202). Research Methods and Procedures: Effects of NNC 38-1202 on paraventr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861661f13605e6ff774db452852cb69d
https://doi.org/10.1038/oby.2006.252