Výsledky vyhledávání - "Peter B. A. McIntyre"

Toluene Dioxygenase-Catalyzed Synthesis and Reactions of cis-Diol Metabolites Derived from 2- and 3-Methoxyphenols

Autor: Christopher C. R. Allen, Amit Gohil, Colin McRoberts, Peter B. A. McIntyre, Peter N. Horton, Paul J. Stevenson, John F. Malone, Narain D. Sharma, Simon J. Coles, Stewart Floyd, Derek R. Boyd

Publikováno v: ResearcherID

Using toluene dioxygenase as biocatalyst, enantiopure cis-dihydrodiol and cis-tetrahydrodiol metabolites, isolated as their ketone tautomers, were obtained from meta and ortho methoxyphenols. Although these isomeric phenol substrates are structurally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb4cda644f48ed1ab317d1be5408f31
https://doi.org/10.1021/jo5028968

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Enzyme-Catalysed Synthesis of Cyclohex-2-en-1-one cis-Diols from Substituted Phenols, Anilines and Derived 4-Hydroxycyclohex-2-en-1-ones

Autor: Patrick Hoering, Peter B. A. McIntyre, Derek R. Boyd, W. Colin McRoberts, Narain D. Sharma, Paul J. Stevenson, Christopher C. R. Allen, Amit Gohil

Publikováno v: Boyd, D R, Sharma, N D, McIntyre, P B A, Stevenson, P J, McRoberts, W C, Gohil, A, Hoering, P & Allen, C 2017, ' Enzyme-Catalysed Synthesis of Cyclohex-2-en-1-one cis-Diols from Substituted Phenols, Anilines and Derived 4-Hydroxycyclohex-2-en-1-ones ', Advanced Synthesis and Catalysis, vol. 359, no. 22, pp. 4002-4014 . https://doi.org/10.1002/adsc.201700711

Toluene dioxygenase-catalysed cis-dihydroxylations of substituted aniline and phenol substrates, with a Pseudomonas putida UV4 mutant strain and an Escherichia coli pCL-4t recombinant strain, yielded identical arene cis-dihydrodiols, which were isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7c412147a7740eabf24c003d44ca53
https://pure.qub.ac.uk/en/publications/enzymecatalysed-synthesis-of-cyclohex2en1one-cisdiols-from-substituted-phenols-anilines-and-derived-4hydroxycyclohex2en1ones(b331c7b4-bac6-479f-9925-0550e6d80a73).html

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Cycloalkenyl Halide Substitution Reactions of Enantiopure Arene cis-Tetrahydrodiols with Boron, Nitrogen and Phosphorus Nucleophiles

Autor: Magdalena Kaik, Mark Bell, Brian Kelly, Peter B. A. McIntyre, Christopher Hardacre, Narain D. Sharma, Derek R. Boyd, Paul J. Stevenson, M. V. Berberian, Christopher C. R. Allen

Publikováno v: Advanced Synthesis & Catalysis. 353:2455-2465

Enantiopure arene cis-tetrahydrodiols of bromobenzene and iodobenzene have been obtained in good yields, from chemoselective hydrogenation (rhodium-graphite) of the corresponding cis-dihydrodiol metabolites. Palladium-catalysed substitution of the ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::900cd6d52c8e9560352a86d031fa833f
https://doi.org/10.1002/adsc.201100273

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ChemInform Abstract: Reactions of Enantiopure Cyclic Diols with Sulfuryl Chloride

Autor: Narain D. Sharma, Peter B. A. McIntyre, Derek R. Boyd, Magdalena Kaik, Paul J. Stevenson, John F. Malone

Publikováno v: ChemInform. 45

Monocyclic allylic cis-diols (I) react with sulfuryl chloride at 0 °C regio- and stereoselectively to give 2-chloro-1-sulfochloridates (II), which can be hydrolyzed to yield the corresponding trans-chlorohydrins (III).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dc4d521bb19fbe1661e16a60d052c59
https://doi.org/10.1002/chin.201435032

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Reactions of enantiopure cyclic diols with sulfuryl chloride

Autor: Paul J. Stevenson, Derek R. Boyd, John F. Malone, Peter B. A. McIntyre, Magdalena Kaik, Narain D. Sharma

Publikováno v: Organicbiomolecular chemistry. 12(13)

Monocyclic allylic cis-1,2-diols reacted with sulfuryl chloride at 0 °C in a regio- and stereo-selective manner to give 2-chloro-1-sulfochloridates, which were hydrolysed to yield the corresponding trans-1,2-chlorohydrins. At −78 °C, with very sl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d8b760d8158c79d65020936c0fe502
https://pubmed.ncbi.nlm.nih.gov/24569926

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Rapid annulation of tropolone units via a pyrylium ylide 1,3-dipolar cycloaddition reaction

Autor: John F. Malone, Kirill Tchabanenko, Peter B. A. McIntyre

Publikováno v: Tetrahedron Letters. 51:86-88

The tropolone subunit of the naturally occurring alkaloid rubrolone aglycon is synthesized via a short reaction sequence starting with a 1,3-dipolar cycloaddition of a pyrylium ylide and indenone, followed by enone oxidation, oxygen-bridge eliminatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05c55ddbebc1a1ceea3bd5e4a83ab989
https://doi.org/10.1016/j.tetlet.2009.10.081

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Chemoenzymatic formal synthesis of (-)- and (+)-epibatidine

Autor: Magdalena Kaik, Derek R. Boyd, Paul J. Stevenson, Peter B. A. McIntyre, Narain D. Sharma, Christopher C. R. Allen

Publikováno v: Boyd, D R, D. Sharma, N, Kaik, M, McIntyre, P B A, Stevenson, P J & Allen, C C R 2012, ' Chemoenzymatic formal synthesis of (-)-and (+)-epibatidine ', Organic and Biomolecular Chemistry, vol. 10, no. 14, pp. 2774-2779 . https://doi.org/10.1039/c2ob06904k

The cis-dihydrocatechol, derived from enzymatic cis-dihydroxylation of bromobenzene using the microorganism Pseudomonas putida UV4, was converted into (-)-epibatidine in eleven steps with complete stereocontrol. In addition, an unprecedented palladiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb8f83c30bd36eeef91f238bcbf9d60
https://pubmed.ncbi.nlm.nih.gov/22367429

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Toluene dioxygenase-catalyzed cis-dihydroxylation of benzo[b]thiophenes and benzo[b]furans: synthesis of benzo[b]thiophene 2,3-oxide

Autor: Timothy A. Evans, Brian T. McMurray, Christopher C. R. Allen, Paul J. Stevenson, John F. Malone, Peter B. A. McIntyre, Derek R. Boyd, Narain D. Sharma, Simon A. Haughey, Ian N. Brannigan

Publikováno v: Organic & Biomolecular Chemistry. 10:7292

Enzymatic cis-dihydroxylation of benzo[b]thiophene, benzo[b]furan and several methyl substituted derivatives was found to occur in both the carbocyclic and heterocyclic rings. Relative and absolute configurations and enantiopurities of the resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff86918421ad688e17ec05f205be3bf
https://doi.org/10.1039/c2ob26120k

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Structure, stereochemistry and synthesis of enantiopure cyclohexenone cis-diol bacterial metabolites derived from phenols

Autor: Peter B. A. McIntyre, Derek R. Boyd, John F. Malone, Jacek Gawronski, Marcin Kwit, Narain D. Sharma, Paul J. Stevenson, Christopher C. R. Allen

Publikováno v: Organic & Biomolecular Chemistry. 10:6217

Biotransformation of 3-substituted and 2,5-disubstituted phenols, using whole cells of P. putida UV4, yielded cyclohexenone cis-diols as single enantiomers; their structures and absolute configurations have been determined by NMR and ECD spectroscopy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b62fa23d78558daeb58c909bb7862a
https://doi.org/10.1039/c2ob25079a

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