Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter B. Uthe"'
Autor:
W. David Wilson, Peter B. Uthe, Justin B. Jones, Alan Sielaff, Moses Lee, Caroline O'Hare, Laura M. Westrate, Jerome Kluza, James P. Lajiness, Binh Nguyen, Toni Brown, Zach Davis, Hilary Mackay, Chrystal D. Bruce, John A. Hartley
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9145-9153
Imidazole (Im) and Pyrrole (Py)-containing polyamides that can form stacked dimers can be programmed to target specific sequences in the minor groove of DNA and control gene expression. Even though various designs of polyamides have been thoroughly i
Autor:
Jim S. Sexton, Keith Mulder, Peter B. Uthe, Zarmeen T. Taherbhai, Toni Brown, Moses Lee, Justin B. Jones
Publikováno v:
Synthetic Communications. 38:33-44
Four N‐formamido‐containing mono‐and diheterocyclic pyrrole‐ and imidazole‐2‐containing acids 1–4 were synthesized as intermediates for the preparation of polyamide molecules. The N‐formamido‐moiety forces the compounds to bind stro
Autor:
Hilary Mackay, Peter B. Uthe, John A Hartley, Toni Brown, Moses Lee, W. David Wilson, Justin B. Jones, Caroline O'Hare, Binh Nguyen, Kevin N. Blackmon
Publikováno v:
Biochemistry. 46:11661-11670
The polyamide N-formamido imidazole-pyrrole-imidazole (f-ImPyIm) binds with an exceptionally high affinity for its cognate site 5'-ACGCGT-3' as a stacked, staggered, and noncovalent cooperative dimer. Investigations are presented into its sequence sp
Autor:
Cameron M. Howard, James A. Henry, N. M. Le, Moses Lee, Peter B. Uthe, Suzanna L. Bailey, Karen L. Buchmueller, Andrew M. Staples, Sarah M. Horick, Kari K. Cox
Publikováno v:
Letters in Drug Design & Discovery. 2:137-142
Autor:
N. Minh Le, Peter B. Uthe, Andrew M. Staples, Binh Nguyen, Cameron M. Howard, Karen L. Buchmueller, W. David Wilson, Kari K. Cox, Sarah M. Horick, Moses Lee, Kimberly A. O. Pacheco
Publikováno v:
Journal of the American Chemical Society. 127:742-750
Pyrrole (Py) and imidazole (Im) polyamides can be designed to target specific DNA sequences. The effect that the pyrrole and imidazole arrangement, plus DNA sequence, have on sequence specificity and binding affinity has been investigated using DNA m
Autor:
Jerome Kluza, John A. Hartley, Caroline O'Hare, Karen L. Buchmueller, Jim S. Sexton, Peter B. Uthe, Daniel Hochhauser, Lloyd V. Flores, Andrew M. Staples, W. David Wilson, Cameron M. Howard, Hilary Mackay, Moses Lee
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(11)
The synthesis and DNA-binding properties of a novel naphthalimide-polyamide hairpin (3) designed to target the inverted CCAAT box 2 (ICB2) site on the topoisomerase IIalpha (topoIIalpha) promoter are described. The polyamide component of 3 was derive
Autor:
Moses Lee, Karen L. Buchmueller, Peter B. Uthe, Andrew M. Staples, Kari K. Cox, Cameron M. Howard, Suzanna L. Bailey, Binh Nguyen, W. David Wilson, Kimberly A. O. Pacheco, James A. Henry, Sarah M. Horick
Publikováno v:
Nucleic Acids Research
Polyamides containing an N-terminal formamido (f) group bind to the minor groove of DNA as staggered, antiparallel dimers in a sequence-specific manner. The formamido group increases the affinity and binding site size, and it promotes the molecules t
Autor:
Justin B. Jones, Peter B. Uthe, Andrew M. Staples, Karen L. Buchmueller, Suzanna L. Bailey, Mark Turlington, Moses Lee, Kevin N. Blackmon
Publikováno v:
Heterocyclic Communications. 11
Autor:
Lloyd V. Flores, Andrew M. Staples, Hilary Mackay, Cameron M. Howard, Peter B. Uthe, Jim S. Sexton, Karen L. Buchmueller, W. David Wilson, Caroline O'Hare, Jerome Kluza, Daniel Hochhauser, John A. Hartley, Moses Lee
Publikováno v:
ChemBioChem; Nov2006, Vol. 7 Issue 11, p1722-1729, 8p
Autor:
Uthe, Peter B., Staples, Andrew M., Turlington, Mark, Jones, Justin B., Blackmon, Kevin N., Bailey, Suzanna L., Buchmueller, Karen L., Lee, Moses
Publikováno v:
Heterocyclic Communications; 2005, Vol. 11 Issue 2, p163-166, 4p