Zobrazeno 1 - 10 of 433 pro vyhledávání: '"Peter B Dervan"'
1
Akademický článek
Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome.
Autor: Paul B Finn, Devesh Bhimsaria, Asfa Ali, Asuka Eguchi, Aseem Z Ansari, Peter B Dervan
Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0243905 (2020)
Pyrrole-imidazole (Py-Im) polyamides are synthetic molecules that can be rationally designed to target specific DNA sequences to both disrupt and recruit transcriptional machinery. While in vitro binding has been extensively studied, in vivo effects
Externí odkaz: https://doaj.org/article/e69207fc8c78448ca363229f849bd1bd
Zobrazit plný text záznamu
2
Akademický článek
Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide.
Autor: Silvia Diaz-Perez, Nathanael Kane, Alexis A Kurmis, Fei Yang, Nicolas T Kummer, Peter B Dervan, Nicholas G Nickols
Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0196803 (2018)
Pyrrole-imidazole (Py-Im) polyamides are synthetic non-genotoxic minor groove-binding small molecules. We hypothesized that Py-Im polyamides can modulate the cellular response to ionizing radiation. Pre-treatment of cells with a Py-Im polyamide prior
Externí odkaz: https://doaj.org/article/a69e65bb62d345b58c3bae12d04a0bc8
Zobrazit plný text záznamu
3
Akademický článek
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
Autor: Amanda E Hargrove, Thomas F Martinez, Alissa A Hare, Alexis A Kurmis, John W Phillips, Sudha Sud, Kenneth J Pienta, Peter B Dervan
Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143161 (2015)
Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen respons
Externí odkaz: https://doaj.org/article/0e0f266dcfb74ee5b9dab35d6f5d1fe0
Zobrazit plný text záznamu
10
Supplementary Figures 1-8 from An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors
Autor: Peter B. Dervan, Jevgenij A. Raskatov, Jerzy O. Szablowski
Supplementary Figure 1: Whole transcriptome analysis of U251 cells dosed with DFO and compounds 1 and 3; Supplementary Figure 2: Preliminary in vivo experiments - quantification of an uptake within of a radiolabeled Py-Im polyamide within tissues and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b492a0761958144e4a0c4c9195a091e5
https://doi.org/10.1158/1535-7163.22508532.v1
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje