Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Peter Angehrn"'
Autor:
Erwin Goetschi, Fabienne Ricklin, Peter Reindl, Raffaello Masciadri, Thomas Luebbers, Helmut Link, Dirk Kostrewa, Paul Hebeisen, Hans Gmuender, Peter Angehrn, Frank-Peter Theil
Publikováno v:
CHIMIA, Vol 57, Iss 4 (2003)
Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.
Externí odkaz:
https://doaj.org/article/ebfc36461a92485ba5c717ea4a86a719
Autor:
Peter Angehrn
Publikováno v:
Wissensmanagement. 2:36-37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ed3e0987ec9a87224963cbd0bf528b
https://doi.org/10.1007/s43443-020-0164-9
https://doi.org/10.1007/s43443-020-0164-9
Autor:
Thomas Braun, David Banner, Reiner Dr. Gentz, Ernst-Juergen Schlaeger, Werner Lesslauer, Gisela Gehr, Peter Angehrn, Hans-Joachim Schoenfeld, Alain d’Arcy, Fabienne Mackay, Hansruedi Loetscher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459b4ce18186cce36f4d69fea5a5c879
https://doi.org/10.1159/000422174
https://doi.org/10.1159/000422174
Autor:
§ and Anne Schmitt-Hoffmann, Dirk Kostrewa, Helmut Link, Hans Gmuender, Fabienne Ricklin, Paul Hebeisen, Peter Reindl, Thomas Luebbers, Peter Angehrn, Raffaello Masciadri, Joergen Nielsen, Christoph Funk, Erwin Goetschi, Frank-Peter Theil, Stefan Buchmann
Publikováno v:
Journal of Medicinal Chemistry. 47:1487-1513
Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of natural products. It acts by competitively inhibiting the ATPase activity exerted by the B sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dcf48e4c826f95e352489e73ea0ec3
https://doi.org/10.1021/jm0310232
https://doi.org/10.1021/jm0310232
Autor:
Akira Sasaki, Yutaka Ueda, Katsumi Kubota, Masanori Itoh, Paul Hebeisen, Rudolf L. Then, Makoto Sunagawa, Peter Angehrn, Erwin Goetschi, Anne Bourson
Publikováno v:
The Journal of Antibiotics. 55:722-757
Discovery of novel antimicrobial agents effective against infections caused by drug-resistant pathogens is an important objective. In order to find a new parenteral carbapenem antibiotic, which has potent antibacterial activity especially against met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3d11f468be26f724d35e5f469bf570
https://doi.org/10.7164/antibiotics.55.722
https://doi.org/10.7164/antibiotics.55.722
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:1376-1381
Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity against staphylococci, enterococci, pneumococci, and streptococci which was considerably better than that of trimethoprim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deb2d2a4d6a71c0e111f029ded5704d
https://doi.org/10.1128/aac.40.6.1376
https://doi.org/10.1128/aac.40.6.1376
Autor:
Christian Hubschwerlen, Malcolm G. P. Page, Valerie Runtz, Paul Hebeisen, Ingrid Heinze-Krauss, Henri Stalder, Hans Richter, Peter Angehrn, Urs Weiss, Wei Chung-Chen, Philippe Guerry, Ivan Kompis
Publikováno v:
Journal of Medicinal Chemistry. 39:1864-1871
The synthesis and structure−activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd751d7fdeabe0758dd8332f0464771
https://doi.org/10.1021/jm950886v
https://doi.org/10.1021/jm950886v
Autor:
and Jean-Luc Specklin, Fritz K. Winkler, Peter Angehrn, Malgosia Kania, Hans Richter, Christian Hubschwerlen, Malcolm G. P. Page
Publikováno v:
Journal of Medicinal Chemistry. 39:3712-3722
A general method for synthesis of 2 beta-alkenyl penam sulfones has been developed. The new compounds inhibited most of the common types of beta-lactamase. The level of activity depended very strongly on the nature of the substituent in the 2 beta-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d31a376f6eab8cce598c7100cec6b0f
https://doi.org/10.1021/jm9601967
https://doi.org/10.1021/jm9601967
Autor:
Paul Hebeisen, Peter Reindl, Thomas Luebbers, Bernd Kuhn, Erwin Goetschi, Fabienne Ricklin, Peter Angehrn, Michael Hennig, Hans Gmuender, Anne Schmitt-Hoffmann
Publikováno v:
Journal of medicinal chemistry. 54(7)
The DNA gyrase inhibitor cyclothialidine had been shown to be a valuable lead structure for the discovery of new antibacterial classes able to overcome bacterial resistance to clinically used drugs. Bicyclic lactone derivatives containing in their 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9530a04b1911d8933e3e58c4115aca
https://pubmed.ncbi.nlm.nih.gov/21388139
https://pubmed.ncbi.nlm.nih.gov/21388139
Autor:
Paul Hebeisen, Helmut Link, Erwin Goetschi, Peter Angehrn, Raffaello Masciadri, Hans Gmuender, Joergen Nielsen
Publikováno v:
Pharmacology & Therapeutics. 60:367-380
Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity against intact bacterial cells. To explore its potential with regard to the development of a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f068eb867c429049fd62052e1289e1
https://doi.org/10.1016/0163-7258(93)90017-8
https://doi.org/10.1016/0163-7258(93)90017-8