Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Peter A. Thomason"'
Autor:
Elena Mandrou, Peter A. Thomason, Peggy I. Paschke, Nikki R. Paul, Luke Tweedy, Robert H. Insall
Publikováno v:
Cells, Vol 13, Iss 13, p 1114 (2024)
Fluorescence resonance energy transfer (FRET) biosensors have proven to be an indispensable tool in cell biology and, more specifically, in the study of G-protein signalling. The best method of measuring the activation status or FRET state of a biose
Externí odkaz:
https://doaj.org/article/2faefb80b8ca457abf4cd467fc113537
Publikováno v:
Cells, Vol 10, Iss 12, p 3485 (2021)
The lamellipodia and pseudopodia of migrating cells are produced and maintained by the Scar/WAVE complex. Thus, actin-based cell migration is largely controlled through regulation of Scar/WAVE. Here, we report that the Abi subunit—but not Scar—is
Externí odkaz:
https://doaj.org/article/9c6c4b0d44cb45ce81e1f5ea7bf4ce2c
Autor:
Peggy Paschke, David A Knecht, Augustinas Silale, David Traynor, Thomas D Williams, Peter A Thomason, Robert H Insall, Jonathan R Chubb, Robert R Kay, Douwe M Veltman
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196809 (2018)
Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated
Externí odkaz:
https://doaj.org/article/e50838345c6640ac94a37f459c8aab21
Autor:
Simona Buracco, Shashi Singh, Sophie Claydon, Peggy Paschke, Luke Tweedy, Jamie Whitelaw, Lynn McGarry, Peter A. Thomason, Robert H. Insall
Cell migration requires the constant modification of cellular shape by reorganization of the actin cytoskeleton. The pentameric Scar/WAVE regulatory complex (WRC) is the main catalyst of pseudopod and lamellipodium formation. Its actin nucleation act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f48453d52e11a3f6ba0b96bfcf8bdf9
https://doi.org/10.1101/2022.05.14.491902
https://doi.org/10.1101/2022.05.14.491902
Autor:
Peter A. Thomason, Yihong Yang, Huaqing Cai, Xiaoting Chao, Meng-Qiu Dong, Yong-Hong Yan, Dong Li, Lei M. Li, Shashi Prakash Singh, Robert H. Insall
Publikováno v:
Journal of Cell Biology. 220
Polarity is essential for diverse functions in many cell types. Establishing polarity requires targeting a network of specific signaling and cytoskeleton molecules to different subregions of the cell, yet the full complement of polarity regulators an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b6d2dd5d47f8d501eefe6a0fa671e2
https://doi.org/10.1083/jcb.202010096
https://doi.org/10.1083/jcb.202010096
Autor:
Peter A. Thomason, Peggy Paschke, Luke Tweedy, Robert H. Insall, Laura M. Machesky, Kirsty J. Martin, Michele Zagnoni
Introduction: \ud Cells migrate over long distances during normal embryonic development and in disease, and they navigate through complex, branched paths. Chemotaxis, cell migration steered by gradients of attractive chemicals, is a central regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90adfe03596bfba7f9bd2a7dd86119c
https://eprints.gla.ac.uk/219638/13/219638.pdf
https://eprints.gla.ac.uk/219638/13/219638.pdf
Autor:
Shashi Prakash Singh, Klemens Rottner, Bruce L. Goode, Qing Tang, Robert H. Insall, Laura M. Machesky, Peter A. Thomason, Sergio Lilla, Matthias Schaks
Publikováno v:
e3000774
PLoS biology
United Kingdom
United States
PLoS Biology
PLoS Biology, Vol 18, Iss 8, p e3000774 (2020)
PLoS biology
United Kingdom
United States
PLoS Biology
PLoS Biology, Vol 18, Iss 8, p e3000774 (2020)
The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE’s proline-rich domain is polyphosphorylated after the complex is activated. Blocking Scar/WAVE activation stops phosphorylation in bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917264947ead4b53224029f138f81d49
https://hdl.handle.net/10033/623244
https://hdl.handle.net/10033/623244
Autor:
Peter A. Thomason, Clelia Amato, Laura M. Machesky, Andrew J. Davidson, Shehab Ismail, Robert H. Insall, Karthic Swaminathan
Publikováno v:
Amato, C, Thomason, P A, Davidson, A J, Swaminathan, K, Ismail, S, Machesky, L M & Insall, R H 2019, ' WASP restricts active rac to maintain cells' front-rear polarization ', Current Biology, vol. 29, no. 24, pp. 4169-4182.e4 . https://doi.org/10.1016/j.cub.2019.10.036
Current Biology
Current Biology
Summary Efficient motility requires polarized cells, with pseudopods at the front and a retracting rear. Polarization is maintained by restricting the pseudopod catalyst, active Rac, to the front. Here, we show that the actin nucleation-promoting fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e71dff1cd156f84ba7ef5d490c1e1
https://www.pure.ed.ac.uk/ws/files/139989163/Davidson_A_WASP_restricts....pdf
https://www.pure.ed.ac.uk/ws/files/139989163/Davidson_A_WASP_restricts....pdf
Autor:
Ewan J. McGhee, Kirsty J. Martin, Laura M. Machesky, Sergio Lilla, Nikolaj Gadegaard, Gabriela Kalna, Jim C. Norman, Peter A. Thomason, Yvette W. H. Koh, Gillian M. Mackay, Matthew Neilson, Heather J. Spence, Amelie Juin, Robert H. Insall, Loic Fort, Marie F.A. Cutiongco
Publikováno v:
Cutiongco, M 2019, ' N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis ', Developmental cell . https://doi.org/10.1016/j.devcel.2019.09.018
Pancreatic ductal adenocarcinoma is one of the most invasive and metastatic cancers and has a dismal 5-year survival rate. We show that N-WASP drives pancreatic cancer metastasis, with roles in both chemotaxis and matrix remodeling. lysophosphatidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5528fa73ea330570a305078fecd9db4
https://eprints.gla.ac.uk/201664/9/201664.pdf
https://eprints.gla.ac.uk/201664/9/201664.pdf
Autor:
Robert H. Insall, Michele Zagnoni, Peter A. Thomason, Laura M. Machesky, Luke Tweedy, Kirsty J. Martin
Chemotaxis, in which cells steer using chemical gradients, drives fundamental biological processes like embryogenesis, metastasis and immune responses. Self-generated chemotaxis, where cells break down abundant attractants to create gradients, is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4327e1129e0f6f478b82b1c3e760e821