Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Peter A. Stockwell"'
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102714- (2023)
Summary: Aberrant DNA methylation is a universal feature of cancer. Here, we present a protocol for generating high-quality genome-scale DNA methylation sequencing data from a variety of human cancer biospecimens including immortalized cell lines, fr
Externí odkaz:
https://doaj.org/article/9183b74f093446f493bf266bd8422511
Autor:
Euan J. Rodger, Gregory Gimenez, Priyadarshana Ajithkumar, Peter A. Stockwell, Suzan Almomani, Sarah A. Bowden, Anna L. Leichter, Antonio Ahn, Sharon Pattison, John L. McCall, Sebastian Schmeier, Frank A. Frizelle, Michael R. Eccles, Rachel V. Purcell, Aniruddha Chatterjee
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106986- (2023)
Summary: Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treatment. There is strong evidence for epigenetic changes, such as DNA methylation, a
Externí odkaz:
https://doaj.org/article/55687d4519234db4bf4b68b7a5ae5db5
Autor:
Priyadarshana Ajithkumar, Gregory Gimenez, Peter A. Stockwell, Suzan Almomani, Sarah A. Bowden, Anna L. Leichter, Antonio Ahn, Sharon Pattison, Sebastian Schmeier, Frank A. Frizelle, Michael R. Eccles, Rachel V. Purcell, Euan J. Rodger, Aniruddha Chatterjee
Publikováno v:
Data, Vol 9, Iss 1, p 8 (2023)
Sequencing-based genome-wide DNA methylation, gene expression studies and associated data on paired colorectal cancer (CRC) primary and liver metastasis are very limited. We have profiled the DNA methylome and transcriptome of matched primary CRC and
Externí odkaz:
https://doaj.org/article/f34097822278464bb35e8c3ac67bf4d0
Autor:
Sultana Mehbuba Hossain, Gregory Gimenez, Peter A. Stockwell, Peter Tsai, Cristin G. Print, Janusz Rys, Bozena Cybulska-Stopa, Magda Ratajska, Agnieszka Harazin-Lechowska, Suzan Almomani, Christopher Jackson, Aniruddha Chatterjee, Michael R. Eccles
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Melanoma is a highly aggressive skin cancer, which, although highly immunogenic, frequently escapes the body’s immune defences. Immune checkpoint inhibitors (ICI), such as anti-PD1, anti-PDL1, and anti-CTLA4 antibodies lead to reactivation of immun
Externí odkaz:
https://doaj.org/article/3a823aa5363644c89dd26356837eee0b
Autor:
Amber M. Helliwell, Peter A. Stockwell, Christina D. Edgar, Aniruddha Chatterjee, Warren P. Tate
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11852 (2022)
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease with variable severity. Patients experience frequent relapses where symptoms increase in severity, leaving them with a marked reduction in quality of life. Previous work
Externí odkaz:
https://doaj.org/article/fbc73694f3c34b15b6d924afab3e9112
Autor:
Chiemi F. Lynch-Sutherland, Aniruddha Chatterjee, Peter A. Stockwell, Michael R. Eccles, Erin C. Macaulay
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Transposable elements (TEs) have an established role as important regulators of early human development, functioning as tissue-specific genes and regulatory elements. Functional TEs are highly active during early development, and interact with import
Externí odkaz:
https://doaj.org/article/0525938dec4c4650af20c8798fb738e2
Autor:
Sarah A. Bowden, Peter A. Stockwell, Euan J. Rodger, Matthew F. Parry, Michael R. Eccles, Cherie Stayner, Aniruddha Chatterjee
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Autosomal dominant polycystic kidney disease (ADPKD) is a heritable disease characterized by bilateral renal enlargement due to the growth of cysts throughout the kidneys. Inheritance of a disease-causing mutation is required to develop ADPKD, which
Externí odkaz:
https://doaj.org/article/ef4a1a1c63234a9285023ed91ad5b92a
Autor:
Aniruddha Chatterjee, Euan J. Rodger, Antonio Ahn, Peter A. Stockwell, Matthew Parry, Jyoti Motwani, Stuart J. Gallagher, Elena Shklovskaya, Jessamy Tiffen, Michael R. Eccles, Peter Hersey
Publikováno v:
iScience, Vol 4, Iss , Pp 312-325 (2018)
Summary: Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune responses in cancer, although the factors involved in PD-L1 regulation are poorly understood. Here we show that loss of global DNA methylation, particularly
Externí odkaz:
https://doaj.org/article/f57d918105734591bb6113f96ed367ba
Autor:
Allison M. Tschirley, Peter A. Stockwell, Euan J. Rodger, Oliver Eltherington, Ian M. Morison, Neil Christensen, Aniruddha Chatterjee, Merilyn Hibma
Publikováno v:
Viruses, Vol 13, Iss 10, p 2045 (2021)
Papillomaviruses (PVs) are double-stranded DNA tumour viruses that can infect cutaneous and mucosal epidermis. Human papillomavirus (HPV) types have been linked to the causality of cutaneous squamous cell carcinoma (cSCC); however, HPV DNA is not alw
Externí odkaz:
https://doaj.org/article/a0551a5373394b939788cbf1daeddf02
A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA
Autor:
Jackie L. Ludgate, James Wright, Peter A. Stockwell, Ian M. Morison, Michael R. Eccles, Aniruddha Chatterjee
Publikováno v:
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Background Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nucleic acid crosslinki
Externí odkaz:
https://doaj.org/article/876519d173b84f5693f060137b509ecb