Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Peter A. Savage"'
Autor:
Jaime L. Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V. Ozerov, Matthew T. Walker, Kathleen Higgins, Mark W. Lingen, Evgeny Izumchenko, Peter A. Savage
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 9, Pp 100399- (2021)
Summary: Immune suppression by CD4+FOXP3+ regulatory T (Treg) cells and tumor infiltration by CD8+ effector T cells represent two major factors impacting response to cancer immunotherapy. Using deconvolution-based transcriptional profiling of human p
Externí odkaz:
https://doaj.org/article/575b6d1e0b9940b8b161dd4b76e3be1e
Autor:
Esther C. Broner, Jonathan A. Trujillo, Michael Korzinkin, Tejaswini Subbannayya, Nishant Agrawal, Ivan V. Ozerov, Alex Zhavoronkov, Lisa Rooper, Nikita Kotlov, Le Shen, Alexander T. Pearson, Ari J. Rosenberg, Peter A. Savage, Vasudha Mishra, Aditi Chatterjee, David Sidransky, Evgeny Izumchenko
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Despite recent advancements, the 5 year survival of head and neck squamous cell carcinoma (HNSCC) hovers at 60%. DCLK1 has been shown to regulate epithelial-to-mesenchymal transition as well as serving as a cancer stem cell marker in colon, pancreati
Externí odkaz:
https://doaj.org/article/2050f94809f344348709fe437dccb6db
Autor:
Victoria Lee, Donald M. Rodriguez, Nicole K. Ganci, Sharon Zeng, Junting Ai, Jaime L. Chao, Matthew T. Walker, Christine H. Miller, David E. J. Klawon, Mary H. Schoenbach, Domenick E. Kennedy, Mark Maienschein-Cline, Nicholas D. Socci, Marcus R. Clark, Peter A. Savage
Publikováno v:
Nature Immunology. 24:487-500
Autor:
James P. Allison, Marcel R. M. van den Brink, Peter A. Savage, Georg Gasteiger, Rebecca Waitz, Joyce Wei, Rajmohan Murali, Stefan Haak, Katharina Kreymborg
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d829ed93c60e41d989d7be77883f6cf3
https://doi.org/10.1158/2326-6066.c.6548447.v1
https://doi.org/10.1158/2326-6066.c.6548447.v1
Autor:
James P. Allison, Marcel R. M. van den Brink, Peter A. Savage, Georg Gasteiger, Rebecca Waitz, Joyce Wei, Rajmohan Murali, Stefan Haak, Katharina Kreymborg
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b727a481c7b56ef303543c8ef459b9
https://doi.org/10.1158/2326-6066.22537442.v1
https://doi.org/10.1158/2326-6066.22537442.v1
Autor:
James P. Allison, Marcel R. M. van den Brink, Peter A. Savage, Georg Gasteiger, Rebecca Waitz, Joyce Wei, Rajmohan Murali, Stefan Haak, Katharina Kreymborg
Supplementary Figure 1. Increased B7-H3 and B7-H4 protein expression in murine prostate tumors. Supplementary Figure 2. Higher abundance of neoplastic epithelium in the absence of B7-H3. Supplementary Figure 3. Comparable levels of serum testosterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582e818236ce6f51f4affc08d3d9a276
https://doi.org/10.1158/2326-6066.22537436
https://doi.org/10.1158/2326-6066.22537436
Autor:
Evgeny Izumchenko, Ping Wu, Nishant Agrawal, Jonathan A. Trujillo, Sherin J. Rouhani, Thomas F. Gajewski, Peng Wang, Mustafa Fatih Abasiyanik, Andrew Wang, Bekim Ameti, Kathleen G. Beavis, Cindy Bethel, Bulent Aydogan, Stephen Jumic, Blake Flood, Savaş Tay, Athalia Rachel Pyzer, Rachael Niemiec, Jeremy P. Segal, Jing Lin, Chaojie Zhen, Peter A. Savage, Marian S. Fernando, Vasudha Mishra, Scott Matushek, Sefika Ozcan, Madeline Hartley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
medRxiv
Scientific Reports
medRxiv
Saliva has significant advantages as a test medium for detection of SARS-CoV-2 infection in patients, such as ease of collection, minimal requirement of supplies and trained personnel, and safety. Comprehensive validation in a large cohort of prospec
Publikováno v:
Annual Review of Immunology. 38:421-453
Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understandin
Autor:
David E J Klawon, Sharon Zeng, Nicholas D. Socci, Christine H. Miller, Victoria Lee, Peter A. Savage
Publikováno v:
Nature immunology
Trends Immunol
Trends Immunol
Unprimed mice harbor a substantial population of 'memory-phenotype' CD8+ T cells (CD8-MP cells) that exhibit hallmarks of activation and innate-like functional properties. Due to the lack of faithful markers to distinguish CD8-MP cells from bona fide
Autor:
Vasudha Mishra, Alka Singh, Xiangying Chen, Ari J. Rosenberg, Alexander T. Pearson, Alex Zhavoronkov, Peter A. Savage, Mark W. Lingen, Nishant Agrawal, Evgeny Izumchenko
Publikováno v:
Br J Cancer
Head and neck squamous cell carcinoma (HNSCC) is a molecularly heterogeneous disease, with a 5-year survival rate that still hovers at ~60% despite recent advancements. The advanced stage upon diagnosis, limited success with effective targeted therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaab8e9db04e000fb19ede8d1e7d45e
https://europepmc.org/articles/PMC8810877/
https://europepmc.org/articles/PMC8810877/