Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Peter A. Rosenthal"'
Autor:
Qu Chen, Kazuhiro Ishii, Haruka Mori, Akemi Nishijima, Satoko Arai, Toru Miyazaki, Peter B. Rosenthal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Cell surface scavenger receptors contribute to homoeostasis and the response to pathogens and products associated with damage by binding to common molecular features on a wide range of targets. Apoptosis inhibitor of macrophage (AIM/CD5L) is
Externí odkaz:
https://doaj.org/article/65f2cfb8c14441ae9da25ef3ba34b6e7
Autor:
Oliver J. Acton, Devon Sheppard, Simone Kunzelmann, Sarah J. Caswell, Andrea Nans, Ailidh J. O. Burgess, Geoff Kelly, Elizabeth R. Morris, Peter B. Rosenthal, Ian A. Taylor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In differentiated CD4+ macrophage and resting T-cells SAMHD1 activity results in the inhibi
Externí odkaz:
https://doaj.org/article/bfb935999e6b47258373d8f78633ef6d
Autor:
Gerard J. Kleywegt, Paul D. Adams, Sarah J. Butcher, Catherine L. Lawson, Alexis Rohou, Peter B. Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R. Baldwin, John M. Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I. Croll, Radostin Danev, Sai J. Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J. Bernard Heymann, Juha T. Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C. Lander, Shee-Mei Lok, Steven J. Ludtke, Garib N. Murshudov, Ryan Pye, Grigore D. Pintilie, Jane S. Richardson, Carsten Sachse, Osman Salih, Sjors H. W. Scheres, Gunnar F. Schroeder, Carlos Oscar S. Sorzano, Scott M. Stagg, Zhe Wang, Rangana Warshamanage, John D. Westbrook, Martyn D. Winn, Jasmine Y. Young, Stephen K. Burley, Jeffrey C. Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 140-151 (2024)
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, m
Externí odkaz:
https://doaj.org/article/0e43f020fe4a4894b6f5aa6a5fd3dc2f
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Vaccinia virus assembly in the cytoplasm of infected cells involves the formation of a biconcave viral core inside the maturing viral particle. The boundary of the core is defined by a pseudohexagonal palisade layer, composed of trimers proj
Externí odkaz:
https://doaj.org/article/2135ede2aae540f587f2a82b8d633b69
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-6 (2022)
Electron cryotomography expands our knowledge of SARS-CoV-2 virus architecture and reveals a distinct and uniform morphology for which interactions between RNP subunits within the nucleocapsid and between the nucleocapsid and the membrane are likely
Externí odkaz:
https://doaj.org/article/73585c3234a44c0eaf62d5d0210df3e5
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Externí odkaz:
https://doaj.org/article/7962a80d2bbe4a1fad840d8055778419
Autor:
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding
Externí odkaz:
https://doaj.org/article/b4dd4e7327c04cb0a388bbe45794406e
Autor:
Andrea J Lopez, Maria Andreadaki, Juha Vahokoski, Elena Deligianni, Lesley J Calder, Serena Camerini, Anika Freitag, Ulrich Bergmann, Peter B Rosenthal, Inga Sidén-Kiamos, Inari Kursula
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011174 (2023)
Actins are filament-forming, highly-conserved proteins in eukaryotes. They are involved in essential processes in the cytoplasm and also have nuclear functions. Malaria parasites (Plasmodium spp.) have two actin isoforms that differ from each other a
Externí odkaz:
https://doaj.org/article/1721cb05aae64ba49b68e7070075ca64
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3002005 (2023)
During its cytoplasmic replication, vaccinia virus assembles non-infectious spherical immature virions (IV) coated by a viral D13 lattice. Subsequently, IV mature into infectious brick-shaped intracellular mature virions (IMV) that lack D13. Here, we
Externí odkaz:
https://doaj.org/article/4a59616b1a694467835702683bc31bc5
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities. Here, the authors apply electron cryotomography of whole
Externí odkaz:
https://doaj.org/article/008ebdb450004020b9d7e1709b5330f9