Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Peter A. Nemoto"'
Autor:
John D. Huber, J. Matthew Hutzler, Doris Riether, Tom Simpson, Alan Olague, Asitha Abeywardane, Renee Zindell, John Broadwater, Peter Allen Nemoto, Hidenori Takahashi, Todd Bosanac, Yunlong Zhang, Alessandra Bartolozzi, Zhidong Chen, Lifen Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:4652-4659
Structure activity relationship (SAR) investigation of an oxadiazole based series led to the discovery of several potent FLAP inhibitors. Lead optimization focused on achieving functional activity while improving physiochemical properties and reducin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7409748ad2ed88f5ff75e6fc34d9eca7
https://doi.org/10.1016/j.bmcl.2017.09.007
https://doi.org/10.1016/j.bmcl.2017.09.007
Autor:
Zhidong Chen, Carl A. Busacca, Shengli Ma, Xingzhong Zeng, Peter Allen Nemoto, Paige E. Mahaney, Jason A. Mulder, Chris H. Senanayake, Jun Wang, Nitinchandra D. Patel, Zhibin Li, Todd Bosanac, Daniel R. Fandrick, Jean-Nicolas Desrosiers, Heewon Lee, Sonia Rodriguez, Jon C. Lorenz, Nathan K. Yee, Joe Gao, Nelu Grinberg, Hidenori Takahashi, Alessandra Bartolozzi, Jinhua J. Song, Keith R. Fandrick
Publikováno v:
Organic Process Research & Development. 21:1427-1434
A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef81a6daa5f5e0f3f7a2d3016570bad
https://doi.org/10.1021/acs.oprd.7b00202
https://doi.org/10.1021/acs.oprd.7b00202
Autor:
Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df6a496eb118478cab46c6fde2569f9
https://doi.org/10.1016/j.bmcl.2011.05.126
https://doi.org/10.1016/j.bmcl.2011.05.126
Autor:
Richard M. Nelson, Emeigh Jonathan Emilian, Terence A. Kelly, Gregory W. Peet, Eugene R. Hickey, Jiang-Ping Wu, Jun Li, Clare Zimmitti, Janice R. Brickwood, John D. Ginn, Charles L. Cywin, Melissa Foerst, David Stefany, Erika Scouten, Roman Wolfgang Fleck, Zhidong Chen, Mohammed A. Kashem, Daniel Richard Marshall, Steve M. Weldon, Ming-Hong Hao, Weimin Liu, Matt Hrapchak, Catron Katrina Mary, Ian Potocki, Tina Morwick, Peter Allen Nemoto, Michel Liuzzi, Leslie Martin, Denise Spero, Alison Capolino, Michael Robert Turner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5547-5551
An SAR study that identified a series of thienopyridine-based potent IkappaB Kinase beta (IKKbeta) inhibitors is described. With focuses on the structural optimization at C4 and C6 of structure 1 (Fig. 1), the study reveals that small alkyl and certa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bf342a17513439f8b8c45db25f9d37
https://doi.org/10.1016/j.bmcl.2009.08.054
https://doi.org/10.1016/j.bmcl.2009.08.054
Autor:
Michael P. Winters, Renee L. DesJarlais, Mark Bobko, John P. Wolak, Ho Yin Lo, Steven S. Pullen, Deborah D. Jeanfavre, Hnin Hnin Khine, Rosemarie H. Sallati, Ernest L. Raymond, Mohammed A. Kashem, Lei Qiao, Gregory P. Roth, Declan Ryan, Joseph R. Woska, Kevin J. Moriarty, Darius Robinson, Hidenori Takahashi, B. Tomczuk, Wilson Matthew Allan, Ronald L. Magolda, Peter Allen Nemoto, Andre White, Brian Nicholas Cook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5545-5549
A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure-activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77216c0a135ce0c04945949b146cd09c
https://doi.org/10.1016/j.bmcl.2008.09.015
https://doi.org/10.1016/j.bmcl.2008.09.015
Autor:
Zhidong Chen, Shengli Ma, Rolf Schmid, Frederic G. Buono, Keith R. Fandrick, Heewon Lee, Xingzhong Zeng, Sonia Rodriguez, Jean-Nicolas Desrosiers, Zhibin Li, Todd Bosanac, Nathan K. Yee, Paige E. Mahaney, Hidenori Takahashi, Chris H. Senanayake, Joe Gao, Daniel R. Fandrick, Peter Allen Nemoto, Bo Qu, Juergen Daeubler, Adil Duran, Elizabeth Archer, Alessandra Bartolozzi, Jinhua J. Song, Jason A. Mulder, Nitinchandra D. Patel, Nelu Grinberg, Carl A. Busacca, Michael Konrad
Publikováno v:
The Journal of organic chemistry. 80(3)
A practical sequence involving a noncryogenic stereospecific boronate rearrangement followed by a robust formylation with an in situ generated DCM anion has been developed for the asymmetric construction of an all-carbon quaternary stereogenic center
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0a84684926a76865b2c2fecd7837cb
https://pubmed.ncbi.nlm.nih.gov/25562342
https://pubmed.ncbi.nlm.nih.gov/25562342
Publikováno v:
The Journal of Antibiotics. 56:392-398
A series of novel 12-membered ring macrolides was designed based on available information on structure-activity relationships and macrolide-ribosome interactions. Compounds with the desosamine and the anchor group properly attached to the 12-membered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f05e64a6c12543ad6fe8011d564b47
https://doi.org/10.7164/antibiotics.56.392
https://doi.org/10.7164/antibiotics.56.392
Autor:
Fernando Camacho, Fink David M, Olsen Gordon Edward, Lawrence L. Martin, Wayne W. Petko, Richard C. Effland, Hugo M. Vargas, Craig P. Smith, David E. Selk, Douglas K. Rush, Klein Joseph Thomas, Peter Allen Nemoto, Larry Davis, Gina M. Bores, James T. Winslow
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:157-162
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6f4a2e14f8942baf3115f4bd52456a
https://doi.org/10.1016/s0960-894x(96)00592-6
https://doi.org/10.1016/s0960-894x(96)00592-6
Autor:
Klein Joseph Thomas, Craig P. Smith, Fink David M, Wayne W. Petko, Richard C. Effland, Douglas K. Rush, Peter Allen Nemoto, Fernando Camacho, Olsen Gordon Edward, Larry Davis, Gina M. Bores, James T. Winslow, David E. Selk, Hugo M. Vargas, Lawrence L. Martin
Publikováno v:
ChemInform. 28
A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of Alzheimer's disease. Compound 5a (P10358, 1-[3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41000ba1c31656f9c84fb42e02ee999a
https://doi.org/10.1002/chin.199720130
https://doi.org/10.1002/chin.199720130
Autor:
John P. Wolak, Ji Wang, Hnin Hnin Khine, Peter Allen Nemoto, Chuk Chui Man, Stéphane De Lombaert, Steven S. Pullen, Hidenori Takahashi, Brian Nicholas Cook, Mohammed A. Kashem, Jörg Bentzien, Andre White, Gregory P. Roth, Fariba Soleymanzadeh, Stanley Kugler
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
Interleukin-2 inducible T-cell kinase (ITK) is a member of the Tec kinase family and is involved with T-cell activation and proliferation. Due to its critical role in acting as a modulator of T-cells, ITK inhibitors could provide a novel route to ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe75d81be2fbcce7cd52565bd9aa148
https://pubmed.ncbi.nlm.nih.gov/19111460
https://pubmed.ncbi.nlm.nih.gov/19111460