Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Peter A. M. de Witte"'
Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
Autor:
Marie Pardon, Pieter Claes, Sarah Druwé, Murielle Martini, Aleksandra Siekierska, Christel Menet, Peter A. M. de Witte, Daniëlle Copmans
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
New pharmacological approaches that target orexin receptors (OXRs) are being developed to treat sleep disorders such as insomnia and narcolepsy, with fewer side effects than existing treatments. Orexins are neuropeptides that exert excitatory effects
Externí odkaz:
https://doaj.org/article/30dde744214246fa83c94fa1c4cdc927
Autor:
Ann-Sofie De Meulemeester, Lise Heylen, Aleksandra Siekierska, James D. Mills, Alessia Romagnolo, Nicole N. Van Der Wel, Eleonora Aronica, Peter A. M. de Witte
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by pathogenic variants in TSC1 and TSC2 genes. TSC patients present with seizures and brain abnormalities such as tubers and subependymal giant cells astrocytoma (SEGA). Despit
Externí odkaz:
https://doaj.org/article/600537e244ea4c42bc9970aeacc6db1a
Autor:
Yifan Zhang, Lise Heylen, Michèle Partoens, James D. Mills, Rafal M. Kaminski, Patrice Godard, Michel Gillard, Peter A. M. de Witte, Aleksandra Siekierska
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have de
Externí odkaz:
https://doaj.org/article/534f33fac8ab4795929ef3e5c79ae077
Autor:
Lise Heylen, Duc-Hung Pham, Ann-Sofie De Meulemeester, Éric Samarut, Adrianna Skiba, Daniëlle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter A. M. de Witte, Aleksandra Siekierska
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Epilepsy is a common disorder of the brain characterized by spontaneous recurrent seizures, which develop gradually during a process called epileptogenesis. The mechanistic processes underlying the changes of brain tissue and networks toward increase
Externí odkaz:
https://doaj.org/article/be5fabb410974bfb91ab6ba8b49ba5fd
Autor:
Daniëlle Copmans, Sara Kildgaard, Emma Roux, Michèle Partoens, Gert Steurs, Xinhui Wang, Wim M. De Borggraeve, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 247 (2022)
PharmaSea performed large-scale in vivo screening of marine natural product (MNP) extracts, using zebrafish embryos and larvae, to identify compounds with the potential to treat epilepsy. In this study, we report the discovery of two new antiseizure
Externí odkaz:
https://doaj.org/article/367a45b4e88e4608b3466080bf98c684
Autor:
Yifan Zhang, Michiel Vanmeert, Aleksandra Siekierska, Annelii Ny, Jubi John, Geert Callewaert, Eveline Lescrinier, Wim Dehaen, Peter A. M. de Witte, Rafal M. Kaminski
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Epilepsy is a chronic brain disorder characterized by recurrent seizures due to abnormal, excessive and synchronous neuronal activities in the brain. It affects approximately 65 million people worldwide, one third of which are still estimate
Externí odkaz:
https://doaj.org/article/6ff38202a6df4a5db9aa95983d4e8524
Autor:
Marlly Guarin, Annelii Ny, Noémie De Croze, Jan Maes, Marc Léonard, Pieter Annaert, Peter A. M. de Witte
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 576 (2021)
Zebrafish embryos (ZFE) have increasingly gained in popularity as a model to perform safety screenings of compounds. Although immersion of ZFE is the main route of exposure used, evidence shows that not all small molecules are equally absorbed, possi
Externí odkaz:
https://doaj.org/article/f700ab93c9b948f184822ffc20e8e96a
Autor:
Daniëlle Copmans, Sara Kildgaard, Silas A. Rasmussen, Monika Ślęzak, Nina Dirkx, Michèle Partoens, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Publikováno v:
Marine Drugs, Vol 17, Iss 11, p 607 (2019)
There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perf
Externí odkaz:
https://doaj.org/article/f55527d449b24d7bb5f42251a1982621
Autor:
Yifan Zhang, Angéla Kecskés, Daniëlle Copmans, Mélanie Langlois, Alexander D Crawford, Berten Ceulemans, Lieven Lagae, Peter A M de Witte, Camila V Esguerra
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125898 (2015)
Dravet syndrome (DS) is one of the most pharmacoresistant and devastating forms of childhood epilepsy syndromes. Distinct de novo mutations in the SCN1A gene are responsible for over 80% of DS cases. While DS is largely resistant to treatment with ex
Externí odkaz:
https://doaj.org/article/d12eb1d873b74534852fe97b8d6e511d
Autor:
Tatiana Afrikanova, Ann-Sophie K Serruys, Olivia E M Buenafe, Ralph Clinckers, Ilse Smolders, Peter A M de Witte, Alexander D Crawford, Camila V Esguerra
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54166 (2013)
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electr
Externí odkaz:
https://doaj.org/article/6facba727b52445dabd7dd90bf8374e8