Zobrazeno 1 - 10
of 749
pro vyhledávání: '"Peter A. Lewis"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The Human Silencing Hub (HuSH) complex silences retrotransposable elements in vertebrates. Here, we identify a second HuSH complex, designated HuSH2, which is centered around TASOR2, a paralog of the core TASOR protein in HuSH. Our findings
Externí odkaz:
https://doaj.org/article/57d14262902c4d49a914349303039769
Autor:
Zhi-Qiang Xu, Slobodan Jergic, Allen T. Y. Lo, Alok C. Pradhan, Simon H. J. Brown, James C. Bouwer, Harshad Ghodke, Peter J. Lewis, Gökhan Tolun, Aaron J. Oakley, Nicholas E. Dixon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader complexes (CLCs). Detailed understanding of the mechanisms by which CLCs open and place
Externí odkaz:
https://doaj.org/article/9e8880c9aa2c40dbb2212545d9c48737
Autor:
Danielle Berkovic, Patrick Vallance, Ian A. Harris, Justine M. Naylor, Peter L. Lewis, Richard de Steiger, Rachelle Buchbinder, Zanfina Ademi, Sze-Ee Soh, Ilana N. Ackerman
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-33 (2023)
Abstract Background Short-stay joint replacement programmes are used in many countries but there has been little scrutiny of safety outcomes in the literature. We aimed to systematically review evidence on the safety of short-stay programmes versus u
Externí odkaz:
https://doaj.org/article/2125bec16a1b416897fa084be46aa282
Autor:
Mirthe H W van Veghel, Gerjon Hannink, Peter L Lewis, Carl Holder, Liza N van Steenbergen, B Willem Schreurs
Publikováno v:
Acta Orthopaedica, Vol 94 (2023)
Background and purpose: We compared the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) and the Dutch Arthroplasty Register (LROI) regarding patient, prosthesis, and procedure characteristics as well as revision rates
Externí odkaz:
https://doaj.org/article/dcbdfba9eb544dcdaca6e47435024e22
Autor:
Mabel Minji Jung, Siqi Shen, Giovanni A. Botten, Thomas Olender, Koichi R. Katsumura, Kirby D. Johnson, Alexandra A. Soukup, Peng Liu, Qingzhou Zhang, Zena D. Jensvold, Peter W. Lewis, Robert A. Beagrie, Jason K.K. Low, Lihua Yang, Joel P. Mackay, Lucy A. Godley, Marjorie Brand, Jian Xu, Sunduz Keles, Emery H. Bresnick
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a patient with leukemia predisposition syndrome (GATA2 deficiency) with a germline GATA2 variant
Externí odkaz:
https://doaj.org/article/0a1d39017eb14888912ea7fe69a08151
Autor:
Joseph Boktor, Abdul Badurudeen, Manhal Rijab Agha, Peter M. Lewis, Gareth Roberts, Robert Hills, Anthony Johansen, Simon White
Publikováno v:
Bone & Joint Open, Vol 3, Iss 3, Pp 182-188 (2022)
Aims In UK there are around 76,000 hip fractures occur each year 10% to 15% of which are undisplaced intracapsular. There is considerable debate whether internal fixation is the most appropriate treatment for undisplaced fractures in older patients.
Externí odkaz:
https://doaj.org/article/371748fc03814f0bb7f6cf7ae7fc0c55
Autor:
Natalia Moskal, Naomi P. Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N. Lewis, G. Angus McQuibban
Publikováno v:
PLoS Biology, Vol 21, Iss 3 (2023)
Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of dopaminergic neurons. Using an artificial intelligence platform, we employed a natural langua
Externí odkaz:
https://doaj.org/article/afdab6f57e04423884c41f2a0a40427d
Autor:
Ian A Harris, Jacqueline Close, Richard S de Steiger, Sam Adie, Steven E Graves, Michelle Lorimer, Thu-Lan Kelly, Justine M Naylor, Tamara Hooper, Margaret Rogers, Peter L Lewis, John E Farey, Tania Alland, Adriane M Lewin
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Hip fractures treated with total hip arthroplasty (THA) are at high risk of prosthesis instability, and dislocation is the most common indication for revision surgery. This study aims to determine whether dual mobility THA implants reduc
Externí odkaz:
https://doaj.org/article/63f869a3d5434dc99946a2434fac57fb
Publikováno v:
Acta Orthopaedica, Vol 93 (2022)
Background and purpose: Total knee replacement (TKR) studies usually analyze all-cause revision when considering relationships with patient and prosthesis factors. We studied how these factors impact different revision diagnoses. Patients and methods
Externí odkaz:
https://doaj.org/article/af3806da232e4e2095ff835a0b97921b
Autor:
Peter M. Lewis, Faiz J. Khan, Jacob R. Feathers, Michael H. Lewis, Keith H. Morris, James P. Waddell
Publikováno v:
Bone & Joint Open, Vol 2, Iss 5, Pp 293-300 (2021)
Aims: “Get It Right First Time” (GIRFT) and NHS England’s Best Practice Tariff (BPT) have published directives advising that patients over the ages of 65 (GIRFT) and 69 years (BPT) receiving total hip arthroplasty (THA) should receive cemented
Externí odkaz:
https://doaj.org/article/9a363297f2994d5a8b934aa883bb30d0