Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Peter A. Kenny"'
Autor:
Peter W. Kenny
Publikováno v:
Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Ligand efficiency is a widely used design parameter in drug discovery. It is calculated by scaling affinity by molecular size and has a nontrivial dependency on the concentration unit used to express affinity that stems from the inability of
Externí odkaz:
https://doaj.org/article/7a5a1d7a2710425daad7176d7b628a31
Autor:
Peter I Kenny, Karim Kozhaya, Paulina Truong, Mitchell P Weikert, Li Wang, Warren E Hill, Douglas D. Koch
Publikováno v:
Journal of Cataract and Refractive Surgery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0be29f3f6a229346bb7c8e0b869c3057
https://doi.org/10.1097/j.jcrs.0000000000001185
https://doi.org/10.1097/j.jcrs.0000000000001185
Autor:
Antonio C B Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C Gomes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, Carlos A Montanari, José Carlos Quilles, Jean F R Ribeiro, Josmar R Rocha
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005343 (2017)
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for
Externí odkaz:
https://doaj.org/article/c040bb0a668b427ebd712530ad099df5
Publikováno v:
Sexual Medicine Reviews
Introduction The 21st century has seen a series of viral pandemics that have collectively infected millions of individuals. To understand factors that may contribute to viral spread and address long-term health sequelae for survivors, it is important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478177503bea426b1b67559ec944d7d6
https://doi.org/10.1016/j.sxmr.2020.06.003
https://doi.org/10.1016/j.sxmr.2020.06.003
Autor:
Alberto M. Dos Santos, Amanda Ruslana Santana Oliveira, Clauber H. S. da Costa, Peter W. Kenny, Carlos A. Montanari, Jaldyr de Jesus G. Varela, Jerônimo Lameira
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
We have used molecular dynamics (MD) simulations with hybrid quantum mechanics/molecular mechanics (QM/MM) potentials to investigate the reaction mechanism for covalent inhibition of cathepsin K and assess the reversibility of inhibition. The compute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f5074cfdea916454354951ad8857eb
Autor:
Leandro A A Avelar, Cristian D Camilo, Sérgio de Albuquerque, William B Fernandes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, James H McKerrow, Carlos A Montanari, Erika V Meñaca Orozco, Jean F R Ribeiro, Josmar R Rocha, Fabiana Rosini, Marta E Saidel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003916 (2015)
A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and
Externí odkaz:
https://doaj.org/article/c07c0749619b40c0b5dab804ecd2bd13
Autor:
Peter Ignatius Kenny, Larry I. Lipshultz, Amelia Aynaz Khoei, Kevin P. Campbell, Oscar Santiago Velazquez-Castro, John Sullivan
Publikováno v:
Fertility and Sterility. 116:e337-e338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c64f10ae4154542a22ec53d0ef0a31a2
https://doi.org/10.1016/j.fertnstert.2021.07.909
https://doi.org/10.1016/j.fertnstert.2021.07.909
Publikováno v:
Journal of Chemometrics
Energy dispersive X-ray diffraction (EDXRD) and maximum likelihood principal component analysis multivariate curve resolution-alternating least squares (MLPCA-MCR-ALS) with correlation constraint were used to quantify the composition of packaged phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779d257d4da390a3b34f5a7b097f6d80
http://oro.open.ac.uk/75047/1/cem.3329.pdf
http://oro.open.ac.uk/75047/1/cem.3329.pdf
Autor:
Roger Clarnette, Kristine Deang, Paul Yates, Laura D. Baker, Kevin Taddei, Rowena Mobbs, Greg Savage, Stephanie J. Fuller, Heidi Hillebrandt, Kaarin J. Anstey, Tim England, Pratishtha Chatterjee, Belinda M. Brown, Cintia B. Dias, Victor L. Villemagne, Sharon L. Naismith, Mila Kivipelto, Genevieve Z. Steiner, Catriona Ireland, Ralph N. Martins, B. Thompson, Hamid R. Sohrabi, Stephanie R. Rainey-Smith, Edward Barin, Andrew Gleason, Samantha L. Gardener, Tejal M. Shah, Stuart M. Grieve, Ruth Peters, Samantha C. Burnham, Juliana Chen, Rema Raman, Peter W. Kenny
Publikováno v:
Alzheimer's & Dementia. 16
Background The highly encouraging findings from the Finnish Geriatric Intervention Study (known as FINGER) led to the global initiative for dementia risk reduction known as world-wide FINGERS (WW FINGERS). As part of the collaboration, our Australian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1247eb28d70474b9a62a18e8252408c3
https://doi.org/10.1002/alz.046955
https://doi.org/10.1002/alz.046955